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The overall structure of the biogenic amine subclass of the G-protein-coupled receptors, and of their ligand binding sites, is discussed with the aim of highlighting the major structural features of these receptors that are responsible for ligand recognition. A comparison is made between biogenic amine receptors, peptide receptors of the rhodopsin class, and the secretin receptors which all have p
Bruton's tyrosine kinase (Btk) is a cytoplasmic protein tyrosine kinase consisting of N-terminal pleck-strin homology (PH) domain followed by Tec homology (TH) domain, Src homology 3 and 2 (SH3 and SH2) domains, and a C-terminal kinase domain. Mutations in the human BTK gene cause the severe immunodeficiency disease X-linked agammaglobulinemia (XLA). The structural and functional basis of several
We take a fairly comprehensive approach to the problem of solving elliptic partial differential equations numerically using integral equation methods on domains where the boundary has a large number of corners and branching points. Use of non-standard integral equations, graded meshes, interpolatory quadrature, and compressed inverse preconditioning are techniques that are explored, developed, mix
The objective was to investigate definitions of frailty used in studies of multi-component health promotion and disease-preventive (HPDP) intervention programmes for community-dwelling frail elderly persons and to review the content, organisation and effects of HPDP interventions. A systematic review of 19 articles was made, and the International Classification of Functioning, Disability and Healt
The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fract
Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved treatment for patients with initial inhibitor tit
Steroid injections are often employed as an alternative treatment for radicular pain in patients with degenerative spinal disorders. Prospective randomised studies of the lumbar spine reveal contradictory results and non-randomised and most often retrospective studies of the cervical spine indicate pain reduction from steroid injections. No prospective randomised study on transforaminal steroid in
Charge-charge interactions in proteins are important in a host of biological processes. Here we use C-13 NMR chemical shift data for individual aspartate and glutamate side chain carboxylate groups to accurately detect site-specific protonation equilibria in a variant of the B1 domain of protein G (PGB1-QDD). Carbon chemical shifts are dominated by changes in the electron distribution within the s
This paper describes a Cassegrain optics-based chemiluminescence sensor (CS) for measurements in gas turbine combustors. The chemiluminescence sensor measures the equivalence ratio of reacting fuel and air mixtures, and can identify the flame location, in partially premixed flames. It has the potential for monitoring the degree of premixedness of reacting fuel and air in industrial gas turbine com
A new, robust technique for preparing highly selective molecularly imprinted films (see Figure) is presented. Spin-coating is used to spread a pre-polymerization mixture on a substrate, which is subsequently cured with UV light. Important aspects of this technique include the use of a novel polymeric porogen dissolved in a low-volatility solvent to generate porous morphologies with enhanced bindin
Observational and longitudinal observational studies (LOS) provide essential information about the course and outcome of rheumatic disorders that cannot be provided by randomized controlled trials, and they constitute the major clinical scientific communication in rheumatology. There has been no consensus as to the full and appropriate content of LOS. This report defines a core set of domains and
Adsorption to microcrystalline cellulose (Avicel) of pure cellobiohydrolase I and II (CBH I and CBH II) from Trichoderma reesei has been studied. Adsorption isotherms of the enzymes were measured at 4 degrees C using CBH I and CBH II alone and in reconstituted equimolar mixtures. Several models (Langmuir, Freundlich, Temkin, Jovanovic) were tested to describe the experimental adsorption isotherms.
We present a batch method for recovering Euclidian camera motion from sparse image data. The main purpose of the algorithm is to recover the motion parameters using as much of the available information and as few computational steps as possible. The algorithm thus places itself in the gap between factorisation schemes, which make use of all available information in the initial recovery step, and s
OBJECTIVE: To develop an algorithm to detect the edges between lung tissue, perivascular interstitium, and microvessel using digital processing of in vivo microscopic images of lung surface. METHODS: A numerical technique was developed to identify three different regions (namely, pulmonary microvessel, perivascular interstitium, and lung tissue) based on their corresponding gray level distribution
Objectives This study evaluated the role of pre-procedural clinical variables to predict procedural and clinical outcomes of catheter ablation in patients with long-lasting persistent atrial fibrillation (AF). Background Catheter ablation of persistent AF remains a challenging task. Methods Catheter ablation was performed in 90 patients (76 men, age 57 +/- 11 years) with long-lasting persistent AF
Objectives This study examined the degree to which long workhours in combination with an extended workweek (12 hours/7 days) with permanent day shifts (0700-1900), as requested by the workers, influenced biomarkers for stress, metabolic processes, and diurnal rhythm. Methods Construction workers (N=50) working 84 hours a week, with alternate weeks off, were compared with construction workers (N=25
ObjectiveTo investigate if caesarean section (CS) increases the risk for childhood asthma and gastroenteritis with reference made to children born with vaginal delivery (VD). MethodsRetrospective study of data from linked Swedish medical service registers - Medical Birth Registry (MBR) and Hospital Discharge Registry (HDR). Data were obtained from women without any background/perinatal morbidity
Recent advances in the synthesis of biomimetic asym. dinuclear transition metal complexes are reviewed. Emphasis is put on description of asym. model complexes for the active sites of the enzymes purple acid phosphatase, zinc phosphotriesterase, urease, Cu, Zn superoxide dismutase, tyrosinase, and catechol oxidase.
