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One year ago, we discovered a new family of insect RYamide neuropeptides, which has the C-terminal consensus sequence FFXXXRYamide, and which is widely occurring in most insects, including the fruitfly Drosophila melanogaster and the red flour beetle Tribolium castaneum (F. Hauser et al., J. Proteome Res. 9 (2010) 5296-5310). Here, we identify a Drosophila G-protein-coupled receptor (GPCR) coded f
What explains variation in military spending? Conventional wisdom suggests that states arm because of either foreign threats or domestic political institutions. The literature treats these factors as distinct and separate (Nordhaus et. al. 2012, Fordham and Walker 2005, Goldsmith 2003). Less attention is given to how states with different internal constraints respond to similar circumstances. This
Analyses of foraminiferal assemblages have often been implemented on dry samples, which are easy to split. In some cases, the wet-picking method is preferred as it allows the preservation of more foraminiferal forms and facilitates the picking of live foraminifera. However, the increased execution time needed for wet picking may cause micropalaeontologists to refrain from employing it in a routine
The environment of the Tibetan Plateau (TP) is regarded as one of the most sensitive ecosystems of the world. However, investigations on effects caused by global climate change or anthropogenic activities are rare due to its quite remote location. This thesis deals with various aspects of the carbon and water cycle within ecological and hydrological studies that can be assessed by measurements of
When reconstructing combined defects of the cervical spine and the posterior pharyngeal wall the goals are bone stability along with continuity of the aerodigestive tract. We present a case of a patient with a cervical spine defect, including C1 to C3, associated with a posterior pharyngeal wall defect after excision of a chordoma and postoperative radiotherapy. The situation was successfully solv
Microtubule-disturbing drugs inhibit lysosomal trafficking and induce lysosomal membrane permeabilization followed by cathepsin-dependent cell death. To identify specific trafficking-related proteins that control cell survival and lysosomal stability, we screened a molecular motor siRNA library in human MCF7 breast cancer cells. SiRNAs targeting four kinesins (KIF11/Eg5, KIF20A, KIF21A, KIF25), my
Bicelles are tunable disk-like polymolecular assemblies formed from a large variety of lipid mixtures. Applications range from membrane protein structural studies by nuclear magnetic resonance (NMR) to nanotechnological developments including the formation of optically active and magnetically switchable gels. Such technologies require high control of the assembly size, magnetic response and therma
In the era of the Internet of Things and social media; communities, governments, and corporations are increasingly eager to exploit new technological innovations in order to track and keep up to date with important new events. Examples of such events include the news, health related incidents, and other major occurrences such as earthquakes and landslides. This area of research commonly referred t
In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in neuropsychiatric disorders, namely schizophrenia. Alterations of glutamate and glutamine levels in brains of schizophrenia patients relative to he
The arrival of the Digital Age added a new way to preserve memories of war and conflict. These developments beg deeper reflection on the role of cyberspace and how memories of conflict have become publicly and collectively owned, shared and mediated in the digital space. Cyberspace offers a context for the deposit of digital memorials for victims and casualties of war from any adversary in a confl
Colloidal dispersions have attracted much attention both from academia and industry due to industrial significance and complex dynamic properties. Accordingly, a variety of attempts have been made to understand the complicated physics of colloidal dispersions. Particle dynamics simulation has been playing an important role in exploring colloidal systems as a strong complement to experimental appro
Soot emissions from diesel internal combustion engines are strictly regulated nowadays. Laser extinction measurement (LEM) and natural luminosity (NL) of sooty flames are commonly applied to study soot. LEM measures soot along the laser beam path and it can probe soot regardless of temperature. NL integrates the whole field of view and relies on soot temperature. In this work, a comparison of simu
In 2007, Chinese Ministry of Education (MOE) and Ministry of Housing & Urban-Rural Development (MOHURD) carried out the Campus Resource Conservation Actions, in order to take full use of resources and to improve the energy efficiency. However, due to the large amounts of universities, the total energy consumption and the energy efficiency situation have no objective statistics. Taking modeling
We empirically analyze whether support by the parent organization in the early (nascent and seed) stage speeds up the process of commercialization and helps spin-offs from public research organizations generate first revenues sooner. To identify the impact of support by the parent organization, we apply multivariate regression techniques as well as an instrumental variable approach. Our results sh
The LHCb system requires high efficiency muon detection into LHC bunch crossing: 95% into a 25 ns time window. To reach such efficiency many parameters of the detector readout apparatus have to be calibrated and adjusted and its channels must be aligned in time. In addition, essential characteristics must be monitored to guarantee a good working condition of the apparatus (to avoid loss of efficie
Gene therapy has reached the forefront of studies and research over the last 30 years because of its potential for curing, treating, and preventing diseases associated with DNA mutations. Type 1 and type 2 diabetes are two examples of very common polygenic and multifactorial diseases. The huge amount of scientific literature on this topic reflects a growing general interest in the possibilities of
OBJECTIVE: Although the underlying cause of Huntington's disease (HD) is well established, the actual pathophysiological processes involved remain to be fully elucidated. In other proteinopathies such as Alzheimer's and Parkinson's diseases, there is evidence for impairments of the cerebral vasculature as well as the blood-brain barrier (BBB), which have been suggested to contribute to their patho
The International Society for Stem Cell Research (ISSCR) presents its 2016 Guidelines for Stem Cell Research and Clinical Translation (ISSCR, 2016). The 2016 guidelines reflect the revision and extension of two past sets of guidelines (ISSCR, 2006; ISSCR, 2008) to address new and emerging areas of stem cell discovery and application and evolving ethical, social, and policy challenges. These guidel
