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Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified fiv
We present noble gas analyses of sediment-dispersed extraterrestrial chromite grains recovered from similar to 470 Myr old sediments from two quarries (Hallekis and Thorsberg) and of relict chromites in a coeval fossil meteorite from the Gullhogen quarry, all located ill Southern Sweden. Both the sediment-dispersed grains and the meteorite Gullhogen 001 were generated in the L-chondrite parent bod
In this study, the production of enantiomerically pure (1R,4S,6S)-6-hydroxy-bicyclo[2.2.2]octane-2-one ((-)-2) through stereoselective bioreduction was used as a model reaction for the comparison of engineered Saccharomyces cerevisiae and engineered Escherichia coli as biocatalysts. For both microorganisms, over-expression of the gene encoding the NADPH-dependent aldo-keto reductase YPR1 resulted
The high false negative rates for initial prostate biopsies refer a large number of the men for repeat biopsies each year. Therefore, biomarkers associated with high risk of the presence of malignancy in histologically benign biopsies could provide a tool to discriminate the patients who need repeat biopsy or intensive follow-up from those who do not. Here we examined the diagnostic applicability
Acute management of traumatic brain injury (TBI), in particular mild TBI, focuses on the detection of the 5-7 % who may be harboring potentially life-threatening intracranial hemorrhage (IH) using CT scanning. Guidelines intending to reduce unnecessary head CT scans using available clinical variables to detect those at high IH risk have shown varying results. Recently, the Scandinavian Neurotrauma
This study aims to examine how the sensitivity for macroeconomic announcements surprises changes for the exchange rate in terms of a crisis. Previous research has been biased for U.S announcements and their relation towards emerging market, which has shown that U.S announcements affect more than the domestic. It also suggests that business cycle and uncertainty affect and increase the reaction for
Statsansvaret för folkmord har en jus cogens status i internationell sedvanerätt och utgår från den generella hänförbarhetsregeln: huruvida de inom staten aktiva personer eller grupper är verksamma, eller åtminstone kan anses vara verksamma å statens vägnar är avgörande för att staten kan hållas ansvarig. För att icke-statliga aktörer kan vara hänförliga till staten måste förhållandet dem emellan State responsibility for commission of genocide has a jus cogens status in customary international law and is based on the general rule of attribution: whether the persons or groups acting within the State are acting, or at least can be treated as acting on behalf of the State is key for State responsibility to arise. For non-state actors to be attributable to the State the relationship between th
This study explores the Chinese computational propaganda exploitation during the Covid-19 crisis. By demonstrating the intricacies of this case of computational propaganda utilization, this research attempts to answer an even larger question: How do authoritarian countries incorporate computational propaganda to their soft power strategies. To that end, first; a theoretical bridge was formed betwe
Coastal floodplains are at risk for combined high discharge and sea level events. Consequences when they occur can be several magnitudes greater than the impact from any isolated event. In this thesis the compounding of different river and coastal flood combinations at three case study sites were studied through the use of 1D/2D-hydraulic modelling software LISFLOOD- FP. The areas were; Henån, Äng
While carbon emissions hit an all-time high in 2019 and are expected to grow, it is important to explore strategies for reducing emissions and mitigating climate change. A potential focus for curbing emissions is the flying sector, since air travel is one of the most carbon-intensive activities an individual can engage in. Among air travelers, frequent flyers yield the highest potential for saving
Japan currently faces a rapid increase in labor immigrants due to the decrease of the population. The number of immigrant children is expected to increase because of the open labor immigration policy. Although the education of immigrant children is very complex, Hamamatsu city and Kani city have implemented successful educational policies to solve the problems of out-of-school children. This resea
Statistical comparison of single cases to small samples is a methodology that has been extensively used in, for example, cognitive and clinical neuropsychology. This is most often done to determine changes in cognitive processing after an individual has incurred some type of brain damage. In a clinical setting one often wish to infer whether a patient exhibit abnormally low performance on some cog
The purpose of the thesis was to study the safety and reliability requirements in the automotive industry from a production test perspective. A survey of the requirements in the automotive standard AEC-Q100 was conducted and the implications of compliance with the requirements were analyzed. In addition to this, production data was reanalyzed considering the requirements found in the survey. From
In any storage ring or synchrotron based light source one of the most important factors for generating light with desirable properties is the electron beam itself. The dynamics of the beam must be properly characterised and, ideally, adjusted to the desired values for the light source to be able to deliver radiation of the quality which was decided during its design. This thesis is limited to som
Our world is experiencing accelerated ecological destruction and social injustices on different scales and multiple levels. Unchecked economic growth has been criticised as causing this since the 1970s, but the dominant sustainable development paradigm has perpetuated the belief that economic growth and environmental protection can go hand-in-hand. In response degrowth has emerged in the last deca
Introduction: This study is focused on the development and comparison of different extraction methods for vitamin D (VD) analysis in liver samples. Background: VD deficiency is related to several diseases, so it is crucial to correctly detect and quantify its concentration in the human body. Despite the existing methodologies for VD analysis, the selectivity and the sensitivity of the methods for
The impact that anthropogenic micropollutants have on the environment is increasingly gaining attention. As a result of this, Sweden, among other countries, is looking towards implementing advanced treatment for micropollutant and pharmaceutical product removal from wastewater prior to discharge into the environment. The leading method to achieve this is ozonation, which unfortunately also creates
Pupils tend to experience ‘attentional fatigue’ after persistently demanding their attentional system during school hours, resulting in decreased psychological well-being and a lack of attention, along with losses of other cognitive functions. Previous research found natural elements in a school environment to restore pupils’ depleted attentional system. The present study aimed at investigating na
