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Seeing how climate change disproportionately affects women and children, the voices of young people and women are vital to incorporate into discussions and decision-making processes regarding climate change. This thesis explores the experiences of young women in the climate movement who have participated at the COP climate conferences between 2015-2023. By drawing on the theoretical framework of f
Great investments are planned in the north of Sweden the coming years, not the least in the county of Norrbotten where the projects collectively are referred to as the green transition due to the focus on fossil-free techniques. But to be able to secure a sustainable energy supply and reach the goal set by the member states of the European Union of a carbon dioxide neutral union in 2050 the produc
The Öresund Region, comprising areas of Sweden and Denmark, is involved in a process of sustainable urban transformation. The region has high ambitions in terms of carbon emissions reduction and has set itself steep targets to meet over the next 15-20 years. The energy consumption of buildings accounts for a significant proportion of carbon emissions. With the urban areas of the Öresund Region exp
The recycling sector and the solid waste management systems (SWMS) in developing countries greatly rely on scavengers, a vulnerable and marginal urban population that recover items or materials to be reused or recycled. As a new mindset towards waste emerges, considering it a resource instead of something useless and undesirable; governments, NGOs, private companies and other stakeholders slowly r
In the wake of the globalization, international tax planning structures has become vital for US investors in order to meet economic challenges and to survive on the competitive market. This research indicates that countries in Europe, such as Sweden and Switzerland, provide a favourable environment for US multinational corporations to set up holding companies as a way to enjoy benefits of legal ta
The thesis explores how the political discourse on refugees and asylum seekers is produced within portfolio committee meetings at the South African parliament. A critical discourse analysis investigates how statements of delegates of the Department of Home Affairs and Social Development foster unequal power relations and construct social identities perpetuating the on-going discourse on refugees a
This thesis seeks to answer what causes some governments to restrict foreign funding to domestic civil society organizations while others do not. These repressive measures have increased significantly in all regions of the globe recently and existing research has yet to provide an encompassing explanation for the trend. Considering that neither foreign funding or government repression are exactly
Due to a warming climate, tundra ecosystems are subject to shrub and treeline expansions which could lead to increased above- but decreased belowground carbon (C) stocks. An observed low soil C stock in some subarctic forests and tall shrublands has been suggested to be induced by priming of organic matter decomposition, possibly mediated by ectomycorrhizal fungi. On the other hand, the higher bel
Semantic Web technology has attracted much interest for its ability to integrate and deliver information from different sources, and increasingly, geodata are being published as triple data according to the graph structure laid out in the Resource Description Framework (RDF). Although the Semantic Web already contains a large volume of geotagged information, there is still a lack of suitable geome
This article is a collective response to the 2020 iteration of The Manifesto for Teaching Online. Originally published in 2011 as 20 simple but provocative statements, the aim was, and continues to be, to critically challenge the normalization of education as techno-corporate enterprise and the failure to properly account for digital methods in teaching in Higher Education. The 2020 Manifesto cont
Given the complex nature of agri-food value chains and related sustainability challenges, the question arises who has the agency and responsibility to address these challenges and facilitate systemic change. We address this question through a mixed method approach and examine experiences with agriculture among different actors along the agricultural value chains in Germany. Based on this, we explo
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
Background: Monitoring of healthcare quality is typically focused on differences between group averages in relation to a desirable benchmark. However, we need to consider (i) the existence of interconnected socioeconomic axes of inequality like age, sex, income, and country of birth and (ii) individual heterogeneity around group averages. Additionally, (iii) we need clear criteria to quantify grou
Aims: Stratifying renal damage in type 2 diabetes is challenging due to overlapping features between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). While miR-27b-3p modulates kidney fibrosis in DN through the lysine63 ubiquitination pathway, its upstream regulation and diagnostic relevance remain unclear. Methods: In a biopsy-verified cohort of 231 chronic kidney disease (CKD) pa
The vast majority of patients with pancreatic cancer present with unresectable disease and precision medicine is lagging behind. Circulating tumor DNA (ctDNA) has emerged as a promising tool, both as a proxy for tumor burden and for capturing tumor heterogeneity, but optimal gene panels and prognostic cutoffs remain to be determined. Herein, we applied ultra-deep ctDNA sequencing using a customize
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac transplantation. We report a genome-wide association study and multi-trait analysis of DCM (14,256 cases) and three left ventricular traits (36,203 UK Biobank participants). We identified 80 genomic risk loci and prioritized 62 putative effector genes, including several with rare variant DCM associations (MAP3K7, NEDD4L a
The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri
Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat
