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Delayed gadolinium-enhanced MRI of cartilage is a technique for studying the development of osteoarthritis using quantitative T(1) measurements. Three-dimensional variable flip angle is a promising method for performing such measurements rapidly, by using two successive spoiled gradient echo sequences with different excitation pulse flip angles. However, the three-dimensional variable flip angle m
The study aimed to assess, in multiple populations, the role of HLA alleles on early and late age at onset of type 1 diabetes. Stepwise linear regression models were used to determine which HLA class I and class II risk alleles to include. High-resolution genotyping data for patients from the Type 1 Diabetes Genetics Consortium (T1DGC) collection (n = 2,278) and four independent cohorts from Denma
Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual p
The predominantly populated conformation of carbohydrates in solution does not necessarily represent the biologically active species; rather, any conformer accessible without too large an energy penalty may be present in a biological pathway. Thus, the conformational preferences of a naphthyl xyloside, which initiates in vivo synthesis of antiproliferative glycosaminoglycans, have been studied by
Rare-variant association studies in common, complex diseases are customarily conducted under an additive risk model in both single-variant and burden testing. Here, we describe a method to improve detection of rare recessive variants in complex diseases termed RAFT (recessive-allele-frequency-based test). We found that RAFT outperforms existing approaches when the variant influences disease risk i
A search has been performed for photons originating in the decay of a neutral long-lived particle, exploiting the capabilities of the ATLAS electromagnetic calorimeter to make precise measurements of the flight direction of photons, as well as the calorimeter's excellent time resolution. The search has been made in the diphoton plus missing transverse energy final state, using the full data sample
This study analyzes (a) the relation between injury severities, the age of the bicyclist and the speed environment at accident locations (mean travel speed of the traffic flow involved in the accident) where a bicyclist was struck by a motorized vehicle and (b) how these relations differ from those for struck pedestrians. Accident data from Sweden for the years 2004-2008 was used to identify accid
Depression and anxiety disorders are increasing among the general population in the Western world. Individuals may need several kinds of treatment in order to maintain health, such as cognitive behavioural therapy (CBT) and drug treatment. However, having an everyday life that "works" is also important, suggesting a need for interventions based on activities that facilitate a satisfying everyday l
The complement system can be activated by three different pathways in the body. It is wanted to be able to detect deficiencies of these activation pathways and Bioporto A/S has acquired the commercial rights to a set of ELISA based assays. There is a need in these commercial assays for optimisation of dilution and wash buffers since the idea with the ELISA kit is to sell it as a “ready-to-use kit”
One of infiltration ponds used in the preliminary step for drinking water production at Vombverket in the southern part of Sweden was set for the experiment in this study. The pond was split into two sides as one side received the source water from Vomb Lake and (untreated side). For another side, the water from the same source was pre-treated by DynaSand filter and PAC before transferred into the
Type 2 diabetes mellitus (T2DM) in children and adolescents is increasing in the world and the United States of America (US). Previous research has shown that the nurse has an important role in the management of T2DM in children and adolescents but few studies has covered how the nurses perceive and experience this role. This paper aimed to describe how nurses in the US experience their role and t
Olympic legacy was previously seen as a potential burden on the host city, however an evolutionary shift has occurred whereby it can now be regarded as an instrument in wider urban policy planning. Sustainable development is a requirement set by some governments, and London 2012 aimed to use the Olympic legacy for sustainable development in the form of urban regeneration. This paper is a case stud
Version date: 30 April 2018 1 of 32 TEDDY Publications and Presentations Publications: 1. TEDDY – The Environmental Determinants of Diabetes in the Young – An Observational Clinical Trial. Hagopian W, Lernmark Å, Rewers M, Simell O, She JX, Ziegler A, Krischer J, Akolkar B. Annals of the New York Academy of Science, Volume: Immunology of Diabetes IV: Progression in Understanding. 2006 Oct;1079:320
The European Union’s identity as a normative power has long been examined and contested, most famously by Ian Manners' conceptualization in his 2002 work, Normative Power Europe. This study critically reassesses the EU's proposed identity through the lens of its responses to two pivotal crises: the Syrian conflict (2012-2015) and the 2016 EU-Türkiye Refugee Deal. The research interrogates
Current automated haematology systems lack the functionality of avian blood analysis using 10x magnification, which is an important feature as it allows for faster and more cost-effective blood analysis. The problem originates from the difference in red blood cell morphology in avian blood compared to mammalian blood, as the former are nucleated. The project was divided in two objectives, finding
In this written study, I have researched video game music from the 90’s and early 2000’s to see what I can learn from the process of composing music for video games, as well as how the hardware and software capabilities of the game consoles shaped the music. First it presents my own background and relation to the subject, next it establishes what functionally separates video game music from conven
The survival of our planet is in crisis, and it is affecting society at large. People recognise companies have significantly contributed to the problem, and stakeholders expect and demand businesses to do better. Nowadays, there are strong arguments in sustainability for engaging with as many employees as possible to find novel and innovative solutions more quickly. This study investigated how a p
Introduction The care needs of cancer patients can vary greatly across the course of their serious illness. Despite national efforts to promote supportive care – early integrated palliative care – in Sweden, systemic barriers such as ambiguous terminology and stigma complicate this development. Region Skåne Serious Illness Database (RSSID) is being developed to collect large-cohort data for condu
Contemporary processes of radicalization into far-right extremism are increasingly shaped by digital, online communication environments that convey ideology through multiple communication modes, as well as aesthetic and culturally embedded forms of expression. Short-form content platforms such as TikTok enable fast production and circulation of highly engaging content that creates communicative ar
