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The type III receptor tyrosine kinase FLT3 is a pivotal kinase for hematopoietic progenitor cell regulation, with significant implications in acute myeloid leukemia (AML) through mutations like internal tandem duplication (ITD). This study delves into the structural intricacies of FLT3, the roles of activation loop mutants, and their interaction with tyrosine kinase inhibitors. Coupled with this,
We need energy intake to provide energy and nutrients to our cells. The amount of daily energy intake should aim for energy balance, which results in good health. Under-or overconsumption of total daily energy over a longer period leads to increased risk of diseases. In this scoping review, the components of daily energy requirement are defined. Several methods to estimate energy requirements and
To probe into the artistic possibilities of Artificial Intelligence (AI) generating operatic elements, we have engaged in a practice-led inquiry as designers and artists. We took the process of prototyping a chamber opera with interactive features as our starting point, exploring how AI could work as a source of stimuli in opera productions, and how prototyping might add to the design and evaluati
Microalgal biomass may have biostimulating effects on plants and seeds due to its phytohormonal content, and harnessing this biostimulating effect could contribute to sustainable agriculture. Two Nordic strains of freshwater microalgae species Chlorella vulgaris and Scenedesmus obliquus were each cultivated in a photobioreactor receiving untreated municipal wastewater. The algal biomass and the su
Context. The Gaia DR3 catalogue contains, for the first time, about 800 000 solutions with either orbital elements or trend parameters for astrometric, spectroscopic, and eclipsing binaries, and combinations of these three. Aims. With this paper, we aim to illustrate the huge potential of this large non-single-star catalogue. Methods. Using the orbital solutions and models of the binaries, we have
Striving to mitigate climate change, the European Union has adopted net-zero greenhouse gas emissions as a target for 2050. In this paper, European chemical industry roadmaps from the past six years are assessed and compared to uncover how the industry envisions its role in the transition to net-zero emissions. The roadmaps are assessed in terms of ambition level, technology and feedstock strategi
This paper looks at the relationship between recurring public transport delays, accessibility to jobs, and travel behaviour in the region of Scania, Sweden. The difference between potential (scheduled) accessibility, observed (actual) accessibility, and behaviour is an important part of this research. This paper contributes to the growing body of literature that uses GTFS data (for both scheduled
The purpose of this paper is to show how requirements engineering techniques can be used to structure the development of non-technical aspects of socio-technical systems, such as guidelines. An adapted requirements engineering approach was chosen to elicit requirements for resilience guidelines within an EU Horizon 2020 multi-national project aimed at developing resilience guidelines for crisis ma
Citation counts have long been considered as the primary bibliographic indicator for evaluating the quality of research—a practice premised on the assumption that citation count is reflective of the impact of a scientific publication. However, identifying several limitations in the use of citation counts alone, scholars have advanced the need for multifaceted quality evaluation methods. In this st
The longevity of the almost 100-year-old Ålandic autonomy has been attributed to, among other things, its ability to evolve and adapt to changing circumstances. This position can be problematized and qualified in at least four ways: firstly, most initiatives to develop the autonomy have come from the Ålandic and not the Finnish side; secondly, the processes leading up to the adoptions of new Auton
Translation is controlled by numerous accessory proteins and translation factors. In the yeast Saccharomyces cerevisiae, translation elongation requires an essential elongation factor, the ABCF ATPase eEF3. A closely related protein, New1, is encoded by a non-essential gene with cold sensitivity and ribosome assembly defect knock-out phenotypes. Since the exact molecular function of New1 is unknow
A novel life-cycle assessment (LCA) model has been developed for the investigation of the environmental impact of the choice of material in cable production. In the first application polyolefin based material and PVC material is used. In both cases equivalent fire behaviour is assumed and a fire model is established based on existing fire statistics. This study represents the second full applicati
In this paper we derive error estimates of the backward Euler–Maruyama method applied to multi-valued stochastic differential equations. An important example of such an equation is a stochastic gradient flow whose associated potential is not continuously differentiable but assumed to be convex. We show that the backward Euler–Maruyama method is well-defined and convergent of order at least 1/4 wit
This article describes how a wheel–rail wear detection parameter based on noise was developed by running a rapid transit train instrumented with microphones in a depot with a small curve radius. This full-scale test made use of previous knowledge gained from lab-scale tests. The lab- and full-scale tests showed that noise could be used as an indicator of wear transition, when normal wear turns int
The present invention relates to the use of an ester of inositoltrisphosphate for the preparation of a medicament for preventing, alleviating or combatting inflammatory conditions in mammals including man. Injury or destruction of tissues should be understood as damage to an aggregation of specialized cells with a particular function both internally and externally in the body, such as different or
Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortco
Experiments manipulating the nutritional environment and the associated microbiome of animals have demonstrated their importance for key fitness components. However, there is little information on how macronutrient composition and bacterial communities in natural food sources vary across seasons in nature and on how these factors affect the fitness components of insects. In this study, diet sample
Context. Transmission spectroscopy is one of the most powerful techniques used to characterize transiting exoplanets, since it allows for the abundance of the atomic and molecular species in the planetary atmosphere to be measured. However, stellar lines may bias the determination of such abundances if their center-To-limb variations (CLVs) are not properly accounted for. Aims. This paper aims to
