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Introduction: Due to its universal applicability for early detection and prediction of cancer stage and disease recurrence, widespread implementation of serum-based prostate-specific antigen (PSA) measurements has a significant influence on current treatment strategies for men with prostate cancer (PCa). However, over-detection and the resultant over-treatment of indolent cancers have been strongl
While the Transformer architecture has become ubiquitous in the machine learning field, its adaptation to 3D shape recognition is non-trivial. Due to its quadratic computational complexity, the self-attention operator quickly becomes inefficient as the set of input points grows larger. Furthermore, we find that the attention mechanism struggles to find useful connections between individual points
Ice fragments are generated by sublimation of ice particles in subsaturated conditions in natural clouds. Conceivably, such sublimational breakup would be expected to cause ice multiplication in natural clouds. Any fragment that survives will grow to become ice precipitation that may sublimate and fragment further. As a first step toward assessing this overlooked process, a formulation is proposed
The magnon Hedin's equations are derived via the Schwinger functional derivative technique, and the resulting self-consistent Green's function (GF) method is used to calculate ground state spin patterns and magnetic structure factors for two-dimensional magnetic systems with frustrated spin-12 Heisenberg exchange coupling. Compared with random phase approximation treatments, the inclusion of a sel
Globally, there is a widespread consensus that the transition to circular economy (CE) within the construction industry represents a crucial pathway to achieve the decarbonization of the industry by 2050 while fostering economic growth. At the European level, policies and legislations are progressively promoting the use of circular building products and encouraging higher levels of energy and reso
Earth's life support systems depend on biodiversity and healthy ecosystems. Without radical transformations, staying within safe planetary boundaries becomes impossible. While the inequalities between Global North and Global South are increasingly acknowledged, the agency and rights of people often placed in the category of 'vulnerable' -women, youth, indigenous peoples and local communities- are
Petrochemical producers both rely upon and generate some of the most problematic substances in the current age of socioecological crisis: fossil fuels and plastics. With mounting calls to cap fossil fuel extraction as well as plastics production, the industry appears to be caught between a rock and a hard place. Nonetheless, betting on continuously increasing global plastic demand, petrochemical p
The reformation and characterisation of the passive film formed on ultra-thin 316 L after hydrogen charging is investigated by combining EBSD, TMDS, XRD, Synchrotron-based XPS, and electrochemical experiments. The results show that ultra-thin foil reforms a passive film after 12 h of hydrogen release in NaCl solution. The reformed passive film is half the thickness of the as-received passive film
Importance: Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. Objective: To evaluate the effect of RIC when initiated in the prehospital setting and continued in the hospital on functional outcome in patients with acute stroke. Desig
Background: Despite improvements in hemophilia care, challenges remain, including treatment burden and impaired quality of life. Gene therapy may overcome these. However, its introduction presents a challenge. Objectives: To outline a function-based gene therapy working model describing critical milestones associated with gene therapy handling, administration, and follow-up to facilitate and imple
The classical model selection criteria, such as the Bayesian Information Criterion (BIC) or Akaike information criterion (AIC), have a strong tendency to overestimate the number of regressors when the search is performed over a large number of potential explanatory variables. To handle the problem of the overestimation, several modifications of the BIC have been proposed. These versions rely on su
In the field of sociophysics, concepts and techniques taken from statistical physics are used to model and investigate some social and political behavior of a large group of humans: their social network is given by a simple graph and neighboring individuals meet and interact in pairs or small groups. Although most of the established models feature rather simple microscopic interaction rules, the m
We report metallicities for three ∼Gyr-old stars in the Milky Way nuclear star cluster (NSC) using high-resolution near-infrared spectroscopy. We derive effective temperatures from a calibration with Sc line strength, which yields results in good agreement with other methods, and metallicities from spectral fits to Fe i lines. Our derived metallicities range from −1.2 < [Fe/H] < + 0.5, a span of 1
The type III receptor tyrosine kinase FLT3 is a pivotal kinase for hematopoietic progenitor cell regulation, with significant implications in acute myeloid leukemia (AML) through mutations like internal tandem duplication (ITD). This study delves into the structural intricacies of FLT3, the roles of activation loop mutants, and their interaction with tyrosine kinase inhibitors. Coupled with this,
We need energy intake to provide energy and nutrients to our cells. The amount of daily energy intake should aim for energy balance, which results in good health. Under-or overconsumption of total daily energy over a longer period leads to increased risk of diseases. In this scoping review, the components of daily energy requirement are defined. Several methods to estimate energy requirements and
To probe into the artistic possibilities of Artificial Intelligence (AI) generating operatic elements, we have engaged in a practice-led inquiry as designers and artists. We took the process of prototyping a chamber opera with interactive features as our starting point, exploring how AI could work as a source of stimuli in opera productions, and how prototyping might add to the design and evaluati
Microalgal biomass may have biostimulating effects on plants and seeds due to its phytohormonal content, and harnessing this biostimulating effect could contribute to sustainable agriculture. Two Nordic strains of freshwater microalgae species Chlorella vulgaris and Scenedesmus obliquus were each cultivated in a photobioreactor receiving untreated municipal wastewater. The algal biomass and the su
Context. The Gaia DR3 catalogue contains, for the first time, about 800 000 solutions with either orbital elements or trend parameters for astrometric, spectroscopic, and eclipsing binaries, and combinations of these three. Aims. With this paper, we aim to illustrate the huge potential of this large non-single-star catalogue. Methods. Using the orbital solutions and models of the binaries, we have
Striving to mitigate climate change, the European Union has adopted net-zero greenhouse gas emissions as a target for 2050. In this paper, European chemical industry roadmaps from the past six years are assessed and compared to uncover how the industry envisions its role in the transition to net-zero emissions. The roadmaps are assessed in terms of ambition level, technology and feedstock strategi
