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Defects in the mitochondrial protein frataxin are responsible for Friedreich ataxia, a neurodegenerative and cardiac disease that affects 1:40,000 children. Here, we present the crystal structures of the iron-free and iron-loaded frataxin trimers, and a single-particle electron microscopy reconstruction of a 24 subunit oligomer. The structures reveal fundamental aspects of the frataxin mechanism.

Course literature

Course literature is an important part of your studies. You can access the books you need by borrowing them from the library, buying them new or used, or using online resources. Planning ahead can help you save both time and money. Reading listsUniversity programmes and courses often have long reading lists. These are usually available at the start of the course and include the books you are expec

https://www.lunduniversity.lu.se/current-students/student-services-and-support/literature-and-libraries/course-literature - 2026-06-29

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Evaluating the trade interdependence among countries is the key to understanding critical metal minerals security. By constructing a novel interdependence network, this paper reveals a more comprehensive world hierarchy and risk system of critical metals, and focuses on the interdependencies between China and the US-led MSP countries before and after the Sino-US trade disputes. The results indicat