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Sexually selected traits are often condition-dependent and are expected to be affected by genome-wide distributed deleterious mutations and inbreeding. However, sexual selection is a powerful selective force that can counteract inbreeding through purging of deleterious mutations. Inbreeding and purging of the inbreeding load for sexually selected traits has rarely been studied across natural popul
Class switch recombination (CSR) diversifies antibodies for productive immune responses while maintaining stability of the B-cell genome. Transcription at the immunoglobulin heavy chain (Igh) locus targets CSR-associated DNA damage and is promoted by the BRCT domain-containing PTIP (Pax transactivation domain-interacting protein). Although PTIP is a unique component of the mixed-lineage leukemia 3
The European Spallation Source (ESS) neutron spallation project currently being designed will be built outside of Lund, Sweden. The ESS design includes three helium cryoplants, providing cryogenic cooling for the proton accelerator superconducting cavities, the target neutron source, and for the ESS instrument suite. In total, the cryoplants consume approximately 7 MW of electrical power, and will
The primary aim of the present study was to investigate if methods derived from environmental psychology can be used to study the qualities of the physical environment of supported housing facilities for persons with psychiatric disabilities. Three units of analysis were selected: the private area, the common indoor area, and the outdoor area. Expert assessments of 110 features of the physical env
Ensuring occupants' safety in building fires is one of the most important aspects for fire safety engineering. Many uncertainties are inevitably introduced when estimating the occupant safety level, due to the high complexity of fire dynamics and the human behaviour in fires. Safety factor methods are traditionally employed to deal with such uncertainties. This kind of methods is easy to apply but
OBJECTIVE: The aim of this study was to increase our understanding of the multifaceted phenomenon of home and health, by exploring processes underlying these dynamics when living at home in very old age. METHOD: A qualitative meta-synthesis was used on four complementary qualitative studies, based on data from the Swedish ENABLE-AGE In-depth Study, focusing on very old, single-living people's expe
Genetically diverse infections are common but little is known about what effects coinfecting strains have on each other in natural host-parasite systems. To explore the nature and consequences of interactions in the wild, we studied the tick-transmitted bacterium Borrelia afzelii in one of its main reservoir hosts, the bank vole Myodes glareolus. We measured overall infection intensity with quanti
This Letter reports on a search for narrow high-mass resonances decaying into dilepton final states. The data were recorded by the ATLAS experiment in pp collisions at root s = 7 TeV at the Large Hadron Collider and correspond to a total integrated luminosity of 1.08 (1.21) fb(-1) in the e(+)e(-) (mu(+)mu(-)) channel. No statistically significant excess above the standard model expectation is obse
A review of existing economic models in major depressive disorder (MDD) highlighted the need for models with longer time horizons that also account for heterogeneity in treatment pathways between patients. A core discrete event simulation model was developed to estimate health and cost outcomes associated with alternative treatment strategies.
Regional climate models (RCMs) primarily represent physical components of the climate system, omitting vegetation dynamics, ecosystem biogeochemistry and their associated feedbacks. To account for such feedbacks, we implemented a novel plant individual-based vegetation dynamics-ecosystem biogeochemistry scheme within the RCA3 RCM. Variations in leaf area index (LAI) of seven plant functional type
A search is presented for photonic signatures motivated by generalized models of gauge-mediated supersymmetry breaking. This search makes use of 20.3 fb(-1) of proton-proton collision data at root s = 8 TeV recorded by the ATLAS detector at the LHC, and explores models dominated by both strong and electroweak production of supersymmetric partner states. Four experimental signatures incorporating a
This article discusses the prospects and limitations of the scientific basis for offering personalized nutrition advice based upon individual genetic information. Two divergent scientific positions are presented, with an ethical comment. The crucial question is whether the current knowledge base is sufficiently strong for taking an ethically responsible decision to offer personalized nutrition adv
An attractive option to produce chiral amines of industrial importance is through asymmetric synthesis using ω-transaminase. However, reaching high yields often requires a strategy for shifting the equilibrium position. This paper describes a novel strategy for handling this problem. It involves the use of a supported liquid membrane (SLM) together with a packed bed reactor. The reactor contains E
Dyskinesia and motor fluctuations affect up to 90% of patients with Parkinson's disease (PD) within ten years of L-DOPA pharmacotherapy, and represent a major challenge to a successful clinical management of this disorder. There are currently two main treatment options for these complications, namely, deep brain electrical stimulation or continuous infusion of dopaminergic agents. The latter is ac
Hydrogenation is a universal reaction, which is widely used in industry and academy. However, the reaction is not easy to be studied in extreme conditions such as high temperature and high pressure. On top of that, using Raman spectroscopy to observe the reaction is not so customary. Due to these aspects, the experiment was carried out. During the working process, the degradation reaction was also
In mathematical education it is crucial to have a good teaching plan and to execute it correctly. In particular, this is true in the field of numerical analysis. Every teacher has a different style of teaching. This thesis studies how the basic material of a particular topic in numerical analysis was developed in four different textbooks. We compare and evaluate this process in order to achieve a
Som en följd av EU-beslutet om ett nettonollutsläppsmål till 2050 har flera industrier utvecklat färdplaner för hur dessa utsläppsminskningar ska uppnås. Det här examensarbetet undersöker kemiindustrins färdplaner i syfte att bedöma hur de ser på sin roll i att nå EU:s utsläppsmål. Teknikerna och strategierna som används i färdplanerna för att nå utsläppsminskningar varierar stort. Ofta antas att Following the decision set by the EU of a net-zero greenhouse gas emission target for 2050, several industries have made roadmaps for how these reductions will be achieved. This thesis investigates the chemical industry roadmaps in order to assess how they envision their role in reaching the EU target. The technologies and strategies used in the roadmaps to reach the reduction targets vary widely,
The aim of this project is to establish a workflow that transforms CT-scanned images of paperboard into a calibrated Representative Volume Element (RVE). A RVE is defined as the smallest volume that accurately captures the macroscopic behaviour of the material. First, CT-scanned images are converted into a finite element model that rep- resents the microstructure of the paperboard. Secondly, a di
Bioacoustic sound event detection (SED) is a critical field for biodiversity monitoring, yet the high cost of annotating data poses significant challenges. This thesis explores the application of active learning strategies to reduce the amount of annotated data required for effective model training. This is done for a segment based SED model, where batch active learning is performed by querying fu
