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Due to its compatible oxygen-transporting abilities, hemoglobin (Hb) is a protein of interest in the development of artificial oxygen therapeutics. Despite continuous formulation attempts, extracellular Hb solution often exhibits undesirable reactions when applied in vivo. Therefore, protein engineering is frequently used to examine alternative ways of controlling the unwanted reactions linked to
The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. These infections have been classified as neglected diseases, and still require the development
In 1876, the Kaitakushi, the Japanese government agency responsible for the settlement of the northern island of Hokkaido, hired three Americans from Massachusetts Agricultural College: William Smith Clark, William Wheeler and David Pearce Penhallow. Their task was to establish a comparable institution in Hokkaido, Sapporo Agricultural College, that would spread American-style scientific agricultu
The efficiency of irrigation, as well as optimization of nutrients, affect spinach yield in all growth stages. In this study, the sensitivity of spinach (early and mature yields) to shallow saline groundwater and the effect of fertigation treatments on mature yield were experimentally investigated. The sprinkler irrigation experiments were conducted on 0.47 ha of silty clay soil at the University
Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protective factors for the development of DD using longitudinal population-based data from the Malmö Diet and Cancer S
The use of stem cell derived dopamine neurons for treating patients with Parkinson's disease has now evolved to the first in human clinical trials. In this debate, we argue that assuming these trials give positive outcomes that this therapy will supercede DBS as the neurosurgical treatment of choice for PD patients in the future given it is a one-off therapy that repairs a critical pathway in the
Background & Aims: In 2014, the burden of hepatitis C virus (HCV) in Sweden was evaluated, to establish a baseline and inform public health interventions. Considering the changing landscape of HCV treatment, prevention, and care, and in light of the COVID-19 pandemic, this analysis seeks to evaluate Sweden's progress towards the World Health Organization (WHO) elimination targets and identify
It is well-known that long memory and regime switching in the first moment of a stochastic process are easily confused. But the relation between long memory in the second moment and regime switching in the second moment is less well understood. We perform a simulation study in which we assess the possibility to distinguish the two properties in the case that data with long memory in the second mom
This thesis addresses the highly topical subject of global income inequality within the developed economies. A constructive analysis approach inspired by Swedish political scientists Bo Rothstein, Lennart Lundquist and Björn Badersten is employed analyze the economics blockbuster Capital in the Twenty-First Century by French economist Thomas Piketty. Empirical, normative and constructive theories
The purpose of this thesis is to contribute to the current debate concerning the removal of the statutory audit for SMEs in Sweden. In order to fulfill the thesis purpose a qualitative research approach was used along with triangulation methods. As the basis of the thesis lies in the government report SOU 2008:32 and the official comments to this report, interviews were held with key persons which
In current oat beverage production, insoluble components such as fiber fractions (plant cell structures) are usually decentered from the product, causing many types of loss. Retaining these fractions requires an efficient breakage of them, to avoid sandy mouthfeel in the end-product, which can be achieved for instance by homogenization. To study the homogenization efficiency, the resulted particle
This master thesis presents a suggested Renovation Passport for two typical 1960s single-family houses. Following the recently approved Energy Performance of Buildings Directive (EU 2024/1275A), all member states are to implement voluntary Renovation Passports by 2026, which will aid in reaching the 2050 goal of a decarbonized building stock. The aim of Renovation Passports is to provide long-ter
Glycosaminoglycans comprise linear polysaccharide containing repeated disaccharide units. When one of the disaccharide units of chondroitin sulfate, glucuronic acid, gets epimerized by dermatan epimerase 1 to iduronic acid, dermatan sulfate is formed. Dermatan sulfate is essential in tumorigenesis, due to increased flexibility in the chain and enables interaction with certain proteins such as cyto
This thesis explores the complex relationship between ethnic identity and social mobility within the Māori communities of Aotearoa New Zealand. Central to this research is the role attributed to education, which is seen as a key element in both supporting the preservation of cultural heritage and fostering socio-economic progress. The research examines the contemporary challenges that Māori encoun
Forecasting wind has always been an interesting subject, and as large parts of the world are relying more on wind for power production it is becoming even more important to have reliable forecasts. Probabilistic forecasts, where distributions are predicted in contrast to deterministic forecasts, are impor- tant for informed decision making. We apply two methods based on conformal prediction for pr
Abstract The glycosaminoglycan dermatan sulfate plays a crucial role in the process of tumorigenesis, due to increased flexibility in the polysaccharide chain, when glucuronic acid, in the glycan chondroitin sulfate, epimerizes into iduronic acid. The conversion facilitates a change in the interaction with certain proteins such as growth factors, angiogenic factors, and cytokines. The enzyme invol
Situated in the context of the global rise of the right and growing anti-feminist and anti-gender mobilization, this thesis explores the impacts of Jair Bolsonaro's right-wing populist government (2019-2022) on feminist activism in Brazil from an activist's perspective. It investigates the shifts and disruptions this government has entailed on three levels: in the realms of social public p
This thesis project examines the dynamics of trespass protests, particularly focusing on the Right to Roam (RTR) movement in England. I ask in what ways trespass action for roaming rights challenges private property relations and embodies alternative relations to land and nature. Grounded in historical materialist and political-economic theories, private property is conceptualised as social and sp
