Filetype
This study investigates the manufacturing and application of enteric polymeric microneedles loaded with active pharmaceutical ingredients and combined with photoresponsive dyes used for micromotor motion. The aim is to present an alternative method for orally delivering macromolecules. Although needle fear among patients has led to investigations into alternative routes of administration for macro
This thesis mainly explores how the molecular mobility of lipid and protein components in the outermost layer of the skin, the stratum corneum (SC), varies with different conditions and upon adding foreign compounds. These studies require methods that makes it possible to detect and characterize the minor amount of fluid components in the highly ordered solid SC sample with resolved molecular info
Protease-responsive multi-arm polyethylene glycol-based microparticles with biscysteine peptide crosslinkers (CGPGG↓LAGGC) were obtained for intradermal drug delivery through inverse suspension photopolymerization. The average size of the spherical hydrated microparticles was ∼40 μm after crosslinking, making them attractive as a skin depot and suitable for intradermal injections, as they are read
A new encapsulation strategy for probiotics is highly needed to tackle the challenge of significant viability loss of bacteria during storage and passage through the gastrointestinal system. A new controlled delivery system for probiotics based on EC oleogels is proposed in this thesis. A relatively non-complicated in vitro lipolysis model was established to evaluate the relative conversion from t
The Urban Systems and Dynamics group, led by Prof. Nik, advances the boundaries of Building Physics to explore the complex interactions between buildings, urban systems, and climate. Our research focuses on designing and optimizing strategies for buildings and urban systems (with a big focus on energy systems) that drive the sustainable urban transition and enhance the built environment's resilien
Understanding and therapeutic targeting of lysosome-dependent cell death 1. Deciphering the molecular machinery of lysosome-dependent cell death and its interactions with other cell death and survival processes 2. Understanding the role of lysosomes in diseases with altered cell death 3. Therapeutic modulation of lysosome-dependent cell death 4. Development of novel tools and methods for study
The efficiency with which flying animals convert metabolic power to mechanical power dictates an individual's flight behaviour and energy requirements. Despite the significance of this parameter, we lack empirical data on conversion efficiency for most species as in vivo measurements are notoriously difficult to obtain. Furthermore, conversion efficiency is often assumed to be constant across flig
This article deals with Gunnar Rosendal within church politics in a European perspective. The term church politics is here used in a broad sense, referring to the church’s management of internal problems and conflicts as well as the political strategies of the church in its relation to state and society. In my study I focus on three fields that in various ways got church political consequences o
Modern radiotherapy aims to treat the decease while minimizing the radiation dose to the adjacent normal tissue, to minimize acute and late effects of the treatment. The foremost technological approaches have been intensity modulated radiotherapy (IMRT) and intensity modulated proton therapy (IMPT) in combination with image guided radiotherapy (IGRT). IMRT and IMPT is characterized by a more confo
This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, bu
We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, carboplatin is not specifically toxic to tumour cells and has been associated with neurotoxicity at high infused concentrations in pre-clinical studies. Our treatment strategy requires in
Encapsulation in self-assembled lipid structures has been shown to increase the stability of large biomolecules, including proteins and nucleic acids (NAs), which has many potential applications in the food and pharmaceutical industries. In order to fully optimise the encapsulation system for a certain application, however, it is important to understand the effect of the encapsulated biomolecule o
In fire safety engineering, information about the expected walking speed of occupants through smoke is one factor that is of great interest to the designer. However, despite the fact that research already in the 1970s demonstrated that people tend to evacuate through smoke, little research has been performed on the topic, and evidently there is a lack of data on walking speed in smoke. This has cr
We use the inverse scattering transform to show that a solution of the Camassa-Holm equation is identically zero whenever it vanishes on two horizontal half-lines in the x-t space. In particular, a solution that has compact support at two different times vanishes everywhere, proving that the Carnassa-Holm equation has infinite propagation speed. (c) 2006 Elsevier Inc. All rights reserved.
