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Cellobiose dehydrogenase (CDH) is a sugar oxidizing enzyme secreted by various species of wood degrading fungi to assist the process of wood degradation. It can oxidise analytically relevant sugars as cellobiose, lactose or glucose leading to a gain of two electrons per sugar molecule. CDH consists of a flavin containing catalytic domain (DH) and a haem containing electron mediating domain (CYT).
In the existing securities market structure, a securities trade between two parties requires the involvement of several financial intermediaries ensuring the safety of the transaction. However, the complexity of today’s market structure in conjunction with the lack of interoperability between financial data infrastructures and the disalignment of business practices, are causing costs, risks and fr
Sporulation in Ashbya gossypii is induced by nutrient-limited conditions and leads to the formation of haploid spores. Using RNA-seq, we have determined a gene set induced upon sporulation, which bears considerable overlap with that of Saccharomyces cerevisiae but also contains A. gossypii-specific genes. Addition of cyclic AMP (cAMP) to nutrient-limited media blocks sporulation and represses the
The emerging nanowire technology in recent years has attracted an increasing interest for high-speed, low-power electronics due to the possibility of a gate-all-around (GAA) geometry enabling aggressive gate length scaling, together with the ease in incorporating high-mobility narrow band gap III-V semiconductors such as InAs on Si substrates. These benefits make vertical nanowire transistors an a
Depletion of easily accessible fossil energy resources, threat of climate change and political priority to achieve energy self-sufficiency and sustainable solutions prioritize a conscious and smart use of renewable resources to generate a bio-based economy. Bio-based compounds can replace chemicals and fuels that are now mainly produced from crude oil. Efficient processes for the conversion of pla
Writing efficient parallel programs is the biggest challenge of the software industry for the foreseeable future. We are currently in a time when parallel computers are the norm, not the exception. Soon, parallel processors will be standard even in cell phones. Without drastic changes in hardware development, all software must be parallelized to its fullest extent. Parallelism can increase perfor
Bees use multiple sensory modalities to perform day-to-day tasks. Light allows them to perceive objects and the general features of their surroundings, enabling them to find food and to navigate safely across the landscape. Although both these tasks involve vision, the requirements of the visual system differ depending upon what the bee wants to achieve; locate a flower to feed from or adjust its
Increasing demands for highly sensitive, accurate, fast and portable analytical assays have led to the development of new analytical tools. The integration of highly specific biological sensing elements and appropriate transducers has enabled design of even more efficient biosensor devices for the detection of target substances. In a clinical setting, early detection of biomarkers is crucial for
Hematopoietic stem cells (HSCs) are of great importance for the body and can be used to treat diseases such as leukemia or autoimmune conditions. To be able to use HSCs more extensively in therapies we need to know more about how they are being regulated, one way to do this is by knocking down genes with RNA interference. In this project we test a new micro RNA (miRNA), called miR30E, to investiga
Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid cascade hypothesis suggests that the aggregation of amyloid beta (Abeta) peptide is involved in the pathogenesis of AD, which is supported by the fact that Abeta overexpression or production of more aggregation-prone variants lead to early-onset dementia. In this work, we mainly studied the in vitro Abet
