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The protein Painless is an ion channel coupled receptor that is present in the mosquito Aedes aegypti transmitting yellow fever. The protein is activated by noxious heat. It has been a long-term goal to determine the protein structure and consequently be able to develop a mosquito repellant. The aims of the thesis were to purify and isolate heterologously expressed Painless from yeast cells and ex
The increase in electric vehicles has led to more vehicles of this kind being involved in accidents. Since there is a risk of a delayed initiation of thermal runaway in these cases, many countries have recommendations for safety distances from crashed vehicles to buildings. This report is a part of theeffort to develop similar guidance for Sweden, which was initiated by the Swedish Civil Contingen
Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.
Titel: Cristiano Ronaldwho? En kvalitativ studie om esportatleter, de nya sportstjärnorna Seminariedatum: 2020-06-04 Ämne/kurs: FEKH29, Examensarbete kandidatnivå i marknadsföring, 15 högskolepoäng Författare: Victor Grundén, Christopher Kewenter och Isak Söderlund Schulz Handledare: Peter Svensson Fem nyckelord: Esport, esportatleter, esportfans, athlete branding och sports marketing Syfte:
The use of stem cell derived dopamine neurons for treating patients with Parkinson's disease has now evolved to the first in human clinical trials. In this debate, we argue that assuming these trials give positive outcomes that this therapy will supercede DBS as the neurosurgical treatment of choice for PD patients in the future given it is a one-off therapy that repairs a critical pathway in the
Optical coherence tomography (OCT) is a non-invasive optical imaging technique providing approximately 10 micrometer resolution of tissue in vivo. Within ophthalmology, OCT has already proven its value and is routinely used for diagnosing retinal diseases. In many other areas the potential of OCT is explored worldwide, while the technique itself is further developed with improved imaging speed, re
The gene for an IgA-binding protein from a group A streptococcal strain was cloned and expressed in Escherichia coli. The IgA-binding protein, called protein Arp, was purified on IgA-Sepharose, allowing complete purification in a single step. Analysis of protein Arp by Western immunoblotting demonstrated a major IgA-binding band, with an apparent molecular weight of 42 kD. The purified protein was
Recently, to reach zero emission levels, some new energy systems based on fuel cells have been developed. This paper presents a review of investigations of these systems by thermodynamics performance, mainly, energy and exergy analysis. With energy analysis, the performance of an energy conversion system cannot be effectively and accurately evaluated. But exergy analysis complements and reinforces
The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endoth
Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively
Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr
