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Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, and its host. Here we describe the identification, purification and characterization of a novel extracellular cysteine proteinase produced by S.pyogenes. This enzyme, designated IdeS for Immunoglobulin G-
The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl
The M protein family of molecules in the group A streptococcus comprises a number of cell surface proteins that interact with the immune system of the host. One of the proteins in this family is the IgA receptor Arp4, which has C repeats similar to those that characterize the known M proteins. The streptococcal strain expressing Arp4 also expresses a second immunoglobulin-binding protein, Mrp4, wh
Ash is produced in combustion of biomass. Sonic part of this matter is called fly ash and is carried by the flow and causes not only air pollution and erosion, but also call affect the thermal radiation. The effects of fly ash particles oil the thermal radiation are considered ill this investigation. By analyzing sampled data in all electrostatic filter, a realistic particle size distribution is f
Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i
A 3D nonlinear finite element analysis modelling framework was developed for simulating the behaviour of beams retrofitted with fibre reinforced polymer (FRP). The ABAQUS program was used for this purpose. Concrete was modelled using a plastic damage model. Steel bars were modelled as an elastic perfectly plastic material, with perfect bond between concrete and steel. A cohesive model was used for
Eosinophils participate in the inflammatory response seen in allergy and helminthic infestation. Their release of granule-bound cationic proteins may play a role in these diseases. Therefore, we investigated mechanisms involved in the release of eosinophil cationic protein (ECP). Serum-opsonized zymosan was phagocytosed by eosinophils, and ECP was released into the phagosomes as judged by immunoel
In the equation for thermal energy output from a flat-plate solar collector (written as a function of the collector mean heat carrier temperature), both the gain and the loss terms are multiplied by the collector efficiency factor, F'. For a concentrating collector with an uneven (non-uniform) irradiation on the absorber, the efficiency factor for the gain term, here called the optical efficiency
The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib
This is for her is a performance about torture and therapy. On stage are two women. A victim and a perpetrator. A patient and a therapist. Torture and therapy always involve two people. Torture is about destroying the trust in other people. It only takes a moment, but it takes a lifetime to get back to everyday life again.
Brevmall 1 Konstnärliga fakulteten i Malmö Disputation och examen inom forskarutbildning Denna guide är framtagen som stöd under disputationsprocessen för doktorander antagna enligt särskild överenskommelse om forskarutbildning mellan Konstnärliga fakulteten, Lunds universitet och - doktorander som antagits inom Konstnärliga forskarskolans (KF) ram, - doktorander i musikpedagogik vid Kungl. Musikh
Sports have been shown to influence and shape humans in many ways. However, how sports background influences decision-making in early stage entrepreneurial ventures has not been examined closely. Hence, this thesis addressed this gap and explored how sports backgrounds influence decision-making in early-stage ventures. More specifically, it delved into how experience as an elite team sports athlet
