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BACKGROUND: The risk of cutaneous squamous cell carcinoma (CSCC) is found to be substantially increased after organ transplantation. The association with specific immunosuppressive regimens has been previously investigated, but results are not concordant. We aimed to clarify the relationship between separate immunosuppressive drugs, drug load, timing and risk of post-transplant CSCC.METHODS: A pop

A genetic algorithm for optimal placement of optical fibers in arbitrary geometries for interstitial photodynamic therapy has been developed. Based on calculated fiber positions, the diffuse light distribution is simulated by solving the diffusion equation by means of the finite element method and the treatment time is calculated. Utilizing an instrument for interstitial photodynamic therapy that

Phasor measurement signals are used as only input to a wide-area power system stabilizer to increase interarea mode damping of the Icelandic system. Modal analysis and time simulations of a detailed model show that frequency difference as PSS input gives a damping improvement that is robust to drastic changes in system topology. Field data from phasor measurement units indicate high signal quality

The Wilms tumor gene, WT1, encodes a zinc-finger DNA binding protein which is thought to function as a tissue specific transcription factor, regulating cell growth and differentiation. High expression of WT1 has been detected in a range of acute leukemias. To elucidate a role for WT1 in leukemogenesis, we transfected the monoblastic cell line U937, which lacks detectable levels of endogenous WT1,

Integrated models are inherently complex and often obscure to any but those who write them. Their usefulness can be greatly enhanced through well-structured, object-oriented design. A robust and computationally efficient Simulink/C++ library of optics, control, finite-element, and visualization routines for modeling radio telescope performance under various operating conditions is being developed

The Euro50 is a proposed optical telescope with an equivalent aperture of 50 m. It will have a segmented primary mirror and full adaptive optics. To study the interaction of the telescope structure, the control system and the optics, an integrated simulation model has been formulated. The mechanical model is a modal version of an Ansys finite element model. The optics model is based on ray tracing

Glyoxal (CHOCHO), as an indicator of photochemical “hot spots”, was for the first time the subject of a differential absorption lidar (DIAL) campaign. The strongest absorption line of glyoxal in the blue wavelength region – 455.1 nm – was chosen as the experimental absorption wavelength. In order to handle the effects of absorption cross-section variation of the interfering gas – nitrogen dioxide

Some leading science programs undertaken with Very Large Telescopes and challenges driving the progress of the Extremely Large Telescopes are discussed together with the corresponding requirements. They concern expolanets, Earth-like planets, habitable zones, formation of stars and galaxies, first stars and cosmology. A description is attempted

The paper describes a novel method for self tuning cylinder pressure based heat release computation that is suitable for online usage in e.g. combustion phasing control applications. The method estimates the polytropic exponents and cylinder pressure offsets immediately preceding and succeeding the combustion event respectively using a fast nonlinear least squares method. The polytropic exponent a

This article examines the modern concept of literary value. Since the late 18th century, the problem of literary value has been regarded, from the point of view of the so called double discourse of value, as a presupposed opposition between material and spiritual ”economies”. Many Romanticist and Modernist authors believe that literature – and in a broader sense art and aesthetics – constitute a v

Gas turbine systems are predominantly designed to be fuelled with gaseous fuels within a limited Wobbe index range (typically HHV=45-55 MJ/Nm3 or 1200-1480 Btu/scf). When low calorific fuel gases are fired, the engine will be forced to operate outside its design envelope. The added mass flow will typically raise the cycle pressure ratio and in two-shaft designs also raise the gas generator shaft s

Background: Borderline ovarian tumors (BOTs) are a subgroup of ovarian malignancies with low malignant potential. Very limited earlier data are available on familial clustering of BOTs with other cancers. We aim to explore histology-specific familial associations among BOTs and associations between BOTs and any invasive cancers.Methods: On the basis of 16.1 million individuals in the Swedish Famil

Gas turbine systems are predominantly designed to be fuelled with gaseous fuels within a limited Wobbe index range (typically HHV=45-55 MJ/Nm3 or 1200-1480 Btu/scf). When low calorific fuel gases are fired, the engine will be forced to operate outside its design envelope. The added mass flow will typically raise the cycle pressure ratio and in two-shaft designs also raise the gas generator shaft s

For older people using long-term care services, the conditions of their life-space may be critical. The relationships between the physical housing environment and aspects of health were examined among older people in Japan (aged 65+ years, N = 1,928) by multivariable logistic regression analysis, adjusting for sociodemographic characteristics. Lack of safety, low access to emergency assistance, lo

Monoclonal antibodies targeting CD20 are central in the treatment of B-cell lymphomas. In diffuse large B-cell lymphoma (DLBCL), inactivating mutations of the histone acetyltransferases CREB-binding protein (CBP) and EP300 are common. Moreover, knockdown of CBP in DLBCL has been shown to result in aberrant transcriptional silencing. Expression of CD20 is sensitive to epigenetic manipulation, and h