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Induction of the mitochondrial permeability transition (MPT) has been implicated in cellular apoptosis and in ischemia-reperfusion injury. During MPT, a channel in the inner mitochondrial membrane, the mitochondrial megachannel, opens and causes isolated mitochondria to swell. MPT and mitochondrial swelling is inhibited by cyclosporin A (CsA), which may also inhibit apoptosis in some cells. Treatm

Programmes driving ELT design are discussed. The nature and evolution of circum-stellar shells and planetary discs are attractive, while the small angular sizes place basic properties, asymmetry and warps, beyond VLT capability. An ELT is neeed to reveal the conversion processes shell - disc - planets, planetary systems, Earth-like planets, habitability and life signatures. Formation and evolution

Popular Abstract in Swedish Arbetsförmåga har kommit att bli ett viktigt begrepp i samhället, men också för individen. Det saknas i dag en tydlig definition av arbetsförmåga, trots att det har en stor inverkan på hur sjukförmåner distribueras och också för den enskilde individens möjlighet att försörja sig. I västvärlden är arbetsförmåga ofta diskuterat i relation till sjukskrivning och en åldrad The overall aim of this thesis was to deepen the understanding of work ability by analyzing how different health professionals experience and perceive work ability and assessments of work ability, and also by analyzing rehabilitation outcomes that are related to work ability. The focus has been on musculoskeletal disorders with associated psychosocial factors. Method. The general approach was indu

Czechoslovak productive efficiency of the iron and steel sector fluctuated below the energy efficiency frontier. Until early 1970s, the country's iron sector was one of the least efficient ones in our sample. It was, however, during the decades of 1970s and 1980s that efficiency measures were adopted and the energy efficiency of the Czechoslovak iron and steel sector increased significantly to, de

Företagsobligationsmarknaden utgör en viktig del av Sveriges kapitalmarknad och har under de senaste åren upplevt en betydande tillväxt. Genom att emittera företagsobligationer har företag möjlighet att inbringa kapital till sin verksamhet, medan investerare erhåller avkastning. En nyckelaktör i denna process är arrangören, som utses av emittenten för att leda projektet. Arrangören spelar en avgörThe corporate bond market is an important part of Sweden's capital market and has experienced significant growth in recent years. By issuing corporate bonds, companies can raise capital for their operations, while investors receive a financial return. A key element in this process is the arranger, who is appointed by the issuer to manage the project. The arranger plays a crucial role, particul

Music and Performing Arts is one of the fields Georgia can pride itself on internationally. While the country is in transition as it officially embarks on its long path to the European Union membership, this study explores the process of Europeanization of Higher Music Education in Georgia. Authors analyze how Higher Music Educational Institutions employ European projects for organizational change

This study describes frequencies and associations between eating difficulties, assisted eating and nutritional status in 520 elderly patients in hospital rehabilitation. Eating difficulties were observed during a meal and nutritional status was assessed with Subjective Global Assessment form. Eighty-two percent of patients had one or more eating difficulties, 36% had assisted eating and 46% malnut

This paper describes the extraction of information on lethal events from the Swedish version of Wikipedia. The information searched includes the persons’ cause of death, origin, and profession. We carried out the extraction using a processing pipeline of available tools for Swedish including a part-of-speech tagger, a dependency parser, and manually-written extraction rules. We also extracted stru

The Large Interferometer For Exoplanets (LIFE) is a proposed space mission that enables the spectral characterization of the thermal emission of exoplanets in the solar neighborhood. The mission is designed to search for global atmospheric biosignatures on dozens of temperate terrestrial exoplanets and it will naturally investigate the diversity of other worlds. Here, we review the status of the m

CONTEXT: As part of a broader institutional initiative, the serious illness care program was implemented in a multi-site academic primary care practice. After 2 years, a minority was observed to be documenting serious illness conversations routinely.OBJECTIVES: We aimed to learn about the motivations and actions of clinicians who routinely conducted and documented serious illness conversations.MET

Accurate prediction of crack growth and strength in glued timber joints and components can be achieved by using cohesive laws in constitutive models. These laws represent the traction-separation relationship that measures the stress transmitted between crack faces in a cohesive zone, and can be obtained directly from experiments. However, studies on measuring the cohesive laws of wood adhesive bon

Background:Serious illness conversations are an iterative, interprofessional, team-based process that includes recommendations about medical care. Yet, it is not clear how clinicians in different role groups work together in this process.Objectives:We sought to examine how interprofessional clinicians in the medical intensive care unit (MICU) who were trained in the serious illness care program (S

This paper discusses the role of mathematics in physics teaching and learning. The intention and strength of science is to describe what happens in the realworld by organizing explanations through theories and theoretical models. It has been widely suggested that learning in science is influenced by views about the nature of scientific knowledge. Furthermore, mathematics is an inherent part of the

Normal ageing in men is associated with a physiological decline in testosterone levels, but adverse environmental or psychosocial factors may also impair testosterone secretion and cause secondary biological changes. In a number of observational or experimental studies in both animals and man, it has been possible to study the influences on gonadal function of stressful life situations. To underst

Transplantation of progenitor cells to the CNS has shown promise in neuronal and glial replacement and as a means of rescuing host neurons from apoptosis. Here we examined the effect of progenitor grafts on neurite extension in the degenerating retina of rd1 ( retinal degeneration 1) mice. Transplantation of retinal progenitor cells induced increased matrix metalloproteinase-2( MMP2) secretion, pa