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Frontotemporal dementia - symptoms and brain pathology
Popular Abstract in Swedish Frontotemporal demens (FTD) är en grupp av demenssjukdomar som främst drabbar hjärnans pannlober och främre tinninglober. Gemensamt för FTD-sjukdomarna är en fortskridande nervcellsförlust och förtvining av framför allt hjärnbarken. Sjukdomen medför personlighetsförändring med beteendestörningar, förändringar i känsloliv och kognitiva svårigheter. En försämring av språkFrontotemporal dementia (FTD) is the clinical term for a heterogeneous group of dementia disorders with symptoms emerging from frontotemporal lobar degeneration (FTLD). FTD encompasses the behavioural variant (bvFTD) and the progressive aphasias: progressive non-fluent aphasia (PNFA) and semantic dementia (SD). Neuropathological classification is based on protein pathology with three major subgrou
Melatonin receptors in pancreatic islets - Linking a genetic variant to functional phenotype
Popular Abstract in Swedish Diabetes är en folksjukdom som kännetecknas av förhöjt blodsocker. Sjukdomens förekomst ökar dramatiskt över hela världen och beskrivs ofta som en pandemi. I huvudsak finns det två olika former av diabetes, typ 1 och typ 2. Typ 1 drabbar oftast barn och ungdomar – de insulinproducerande β-cellerna förstörs av kroppens egna immunförsvar. Vid typ 2 diabetes ser sjukdomsbiDefective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. T2D research has in recent years invested tremendous efforts in identifying new risk variants for the disease. It has proven t
Allograft bone in hip revision: the effect of locally applied pharmacological treatment.
Popular Abstract in Swedish Resultatet efter en höftprotesoperation är otvetydigt gott med smärtfrihet och god funktion ofta livet ut hos de flesta. 2012 opererades i Sverige cirka 16000 patienter med höftprotes och siffran stiger. 3-4% av patienterna drabbas av en proteslossning under de första tio åren och behöver opereras om, en så kallad revision. Den gamla protesen avlägsnas då och ersätts meThe clinical success of primary hip replacement is paramount but the need for revisions will continue to increase due to the increasing number of operated individuals. In Sweden, the number of hip revisions in 2012 exceeded 2,300. During implant loosening, some of the bone in the femur is lost, which can make the revision more difficult. One way of handling bone loss has been the impaction techniq
The hypertension-prone man: A study on the pathogenesis of hypertension with regard to insulin sensitivity
Popular Abstract in Swedish Man har länge känt till att högt blodtryck {hypertoni}, bukfetma och sockersjuka {ålders diabetes} existerar samtidigt hos en och samma individ. Under de senaste decennierna har forskare försökt att hitta en gemensam mekanism till dessa tillstånd. Framför allt de senaste åren har man riktat uppmärksamheten mot det fett- och sockerreglerande hormonet insulin som tycks vaHypertensive individuals, even non-obese, have been shown to be resistant to the insulin-mediated glucose uptake in peripheral tissues {mainly skeletal muscle}. The aim of this study was to investigate hypothetical pathophysiological mechanisms for the development of hypertension with regard to insulin sensitivity in normotensive men with a family history of hypertension (RELs) as compared to men
Studies on cell wall-attached proteins of Streptococcus pyogenes
Popular Abstract in Swedish Grupp A streptokocker (Streptococcus pyogenes) är bakterier som orsakar många vanliga infektioner som halsfluss och svinkoppor (impetigo). De kan också orsaka allvarliga infektioner som under 1900-talet blev alltmer ovanliga. I slutet av 1980-talet började dock allvarliga streptokockinfektioner bli vanligare igen. Det är oklart varför det har skett en ökning av aCell wall-attached proteins (CWPs) are important for the virulence of Gram-positive bacteria, but are also targets for the host immune system. CWPs have a conserved COOH-terminal region, responsible for cell wall-sorting. A pattern based on this conserved region was developed. The pattern identifies genes encoding CWPs, with high sensitivity and specificity, in whole genomes of Gram-positive bacte
Injury-induced activation of vascular smooth muscle cells. Role of specific gene expression and intracellular signalling pathways
Popular Abstract in Swedish Den vanligaste dödsorsaken i västvärlden är hjärt-kärlsjukdom. Därför finns det ett stort intresse att undersöka vilka faktorer som är av avgörande betydelse för att vi ska utveckla t.ex ateroskleros (åderförkalkning). Spelar livsstil och matvanor någon roll eller är det helt och hållet genetiskt betingat? Utvecklingen av förebyggande åtgärder, operationsteknik och postMigration and proliferation of smooth muscle cells (SMC) are important events in the development of atherosclerosis and restenosis following angioplastic surgery. It is important to gain further knowledge about the mechanisms regulating SMC form and function in order to understand the underlying disease process. In this thesis I have used cultured rat aortic SMC and analysed how these cells respon
The changing path of inguinal hernia surgery
Popular Abstract in Swedish Operation för ljumskbråck är den vanligaste operationen inom kirurgin. Sjukdomen drabbar främst män och till största delen de som är i arbetsför ålder. Årligen utförs ca. 20.000 operationer i Sverige. Allt sedan den berömde italienske kirurgen Edoardo Bassini introducerade sin operationsmetod för över 100 år sedan har återfalls-frekvensen varit ca. 15%-20% förutom vid sInguinal hernia repair is the most common operation in general surgery and the main challenge has been to lower the recurrence rate. With the introduction of endoscopic repair in the beginning of the 1990´s, the demand for randomised controlled studies has increased resulting in a growing interest in this surgical field. Standardised techniques with a growing use of tension free mesh repairs, teac
Genus och utbildning : ekonomisk-historiska studier i kvinnors utbildning ca 1870-1970
Popular Abstract in Swedish Avhandlingen består av tre delar. Den första, Från utbildningsmarknad till of-fentlig utbildning. Svensk flickskola 1874-1962, behandlar dels integrationen av flickornas sekundärutbildning i den offentliga utbildningsorganisationen, dels förstärkningen respektive försvagningen av denna speciellt genuskodade utbild-ning. Sekundärutbildningen har varit könssegregerad och The thesis is divided into three sections. The first, “From an education market to public education. The Swedish girls’ school 1874-1962”, deals with the integration of girls’ secondary education into the public education system, as well as with the strengthening and weakening of this special, gender-coded education. Secondary education was gender segregated and integration involved a process of s
Working at norunda scietific station - introduction with attachements en
21 November 2016 Working at the Norunda research station – workplace introduction for distribution to people working temporarily at the research station Norunda is a unit within Lund University’s Centre for Environmental and Climate Research, CEC. Responsibility issues All employees, on their own initiative, are to address shortcomings in the work environment and, if they lack sufficient authority
Publication in trends in genetics
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders Trends in Genetics TIGS 1671 No. of Pages 14 Review Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders Marie E. Jönsson,1,3 Raquel Garza,1,3 Pia A. Johansson,1,3 and Johan Jakobsson1,2,*,@ Highlights Transposable elements (TEs) make up almost half of our genome b
On the role of the proform-conformation for processing and intracellular sorting of human cathepsin G
The serine protease cathepsin G is synthesized during the promyelomonocytic stage of neutrophil and monocyte differentiation. After processing, including removal of an amino-terminal propeptide from the catalytically inactive proform, the active protease acquires a mature conformation and is stored in azurophil granules. To investigate the importance of the proform-conformation for targeting to gr
The use of venous blood gas in assessing arterial acid−base and oxygenation status–an analysis of aggregated data from multiple studies evaluating the venous to arterial conversion (v-TAC) method
Background: Several methods exist to reduce the number of arterial blood gases (ABGs). One method, Roche v-TAC, has been evaluated in different patient groups. This paper aggregates data from these studies, in different patient categories using common analysis criteria. Research design and methods: We included studies evaluating v-TAC based on paired arterial and peripheral venous blood samples. B
Hyresrätt - ett lovligt byte. Om byten från hyresrätt till ägt boende
Bytesrätten har utvecklats i samklang med den svenska bostadspolitiken. Under tidigt 1900-tal fanns det en stark liberal inställning till relationen mellan hyresgäster och hyresvärdar. I 1907 års nyttjanderättslag (1907:36), NyttjL, gällde grundläggande avtalsrättsliga principer. Hyresgäster fick enbart säga upp kontrakt om hyresvärden nekade dem överlåtelse av kontraktet utan skälig anledning. I The right to barter a rented apartment has developed in harmony with the Swedish housing policy. During the early twentieth century a strong liberal doctrine dominated the relationship between tenants and landlords. The usufruct law (nyttjanderättslagen) from 1907, was based on contractual principles. Contracts could be for as long as 25 years in the towns and tenants were only allowed to terminat
Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer
Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information. Methods We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patien
Sustainability-plan-for-lund-university-2020-2026-rev-2025
Sustainability Plan for Lund University 2020-2026 Sustainability Plan for Lund University 2020-2026 REVISED 2025 | APPROVED BY THE VICE-CHANCELLOR 19 JUNE 2025 REG. NO STYR 2025/1078 | LUND UNIVERSITY P H O T O C O V E R : JO H A N P E R S S O N | P H O T O : H Å K A N R Ö JD E R , K E N N E T R U O N A , JO H A N P E R S S O N Contents 1. INTRODUCTION 4 ...........................................
Plastics and sustainable investments download
1 PLASTICS AND SUSTAINABLE INVESTMENTS PLASTICS AND SUSTAINABLE INVESTMENTS An information brief for investors Tobias D Nielsen, IVL Swedish Environmental Research Institute Fredric Bauer, Lund University 2 PLASTICS AND SUSTAINABLE INVESTMENTS Mistra Investor brief nr 1 (2019): Plastics and Sustainable Investments – an information brief for investors Authors: Tobias D Nielsen, IVL Swedish Environm
https://www.lu.se/sites/www.lu.se/files/plastics_and_sustainable_investments_download.pdf - 2026-05-03
LPED 2021 1
Centre for Economic Demography Lund University School of Economics and Management P.O. Box 7083 SE-220 07 Lund, Sweden www.ed.lu/publications/Lund-Papers-in-Economic-Demography/ The Long-term Consequences of More Informative Grading MATTHEW COLLINS , JONAS LUNDSTEDT LUND PAPERS IN ECONOMIC DEMOGRAPHY 2021:1 The long-term consequences of more informative grading? Matthew Collins1,2, Jonas Lundstedt
https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-07/LPED_2021_1.pdf - 2026-05-03
Webbinarium: Doktoranders villkor, rättigheter och skyldigheter
Webbinarium: Doktoranders villkor, rättigheter och skyldigheter | Saco-S Göteborgs universitet Hoppa till huvudinnehåll Öppna sökruta Öppna Huvudmeny Sök på saco.se Bli medlem Råd och stöd Aktuella avtal Arbetsmiljöombud Lön Årlig lönerevision RALS Lönejustering Principer för löneprocessen Inledning Gemensamma löneprinciper Förberedelsearbete Lönerevision Avstämning Överenskommelse om lön vid andr
Global China workshop on African development in a world of energy transitions - The Raoul Wallenberg
Global China workshop on African development in a world of energy transitions - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advic
https://rwi.lu.se/news/global-china-workshop-on-african-development-in-a-world-of-energy-transitions/ - 2026-05-02
