Filetype
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core–shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to impro
The suitability of Hansen solubility parameters as descriptors for modelling analyte retention during reversed-phase chromatographic experiments was investigated. A novel theoretical model using Hansen solubility parameters as the basis for a complete mathematical derivation of the model was developed. The theoretical model also includes the cavitation volumes of the analytes, which were calculate
Aftershock rates seem to follow a power law decay, but the assessment of the aftershock frequency immediately after an earthquake, as well as during the evolution of a seismic excitation remains a demand for the imminent seismic hazard. The purpose of this work is to study the temporal distribution of triggered earthquakes in short time scales following a strong event, and thus a multiple seismic
In this fascinating biography of the Indian revolutionary M. P. T. Acharya (1887–1954), Ole Birk Laursen uncovers the remarkable transnational networks, movements and activities of India’s most important anticolonial anarchist in the twentieth century.Driven by the urge for complete freedom from colonialism, authoritarianism, fascism and militarism, which are rooted in the idea and politics of the
Despite the recent experimental and theoretical progress in the investigation of the nuclear fission process, a complete description still represents a challenge in nuclear physics because it is a very complex dynamical process, whose description involves the coupling between intrinsic and collective degrees of freedom, as well as different quantum-mechanical phenomena. To improve on the existing
Hazardous materials in buildings cause project uncertainty concerning schedule and cost estimation, and hinder material recovery in renovation and demolition. The study aims to identify patterns and extent of polychlorinated biphenyls (PCBs) and asbestos materials in the Swedish building stock to assess their potential presence in pre-demolition audits. Statistics and machine learning pipelines we
BACKGROUND: Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH: An expert committee compiled evidence-based recommendations for laboratory analysis in screening, diagnosis, or monitoring of diabetes. The overall quality of the evidence and the strength of t
This article conceptualizes evolutionary theory as a bridge between existing theorizing in strategic communication on the one hand, the mind sciences on the other. It discusses six core concepts of evolutionary psychology that have a bearing on strategic communication theory: a) the human as a highly flexible social species; b) the regulation of individually-minded vs. collectively-minded behavior
Sodium fluoroacetate (FA) is a metabolic poison that systemically inhibits the tricarboxylic acid (TCA) cycle, causing energy deficiency and ultimately multi-organ failure. It poses a significant threat to society because of its high toxicity, potential use as a chemical weapon and lack of effective antidotal therapy. In this study, we investigated cell-permeable succinate prodrugs as potential tr
The fundamental importance of membrane proteins in drug discovery has meant that membrane mimetic systems for studying membrane proteins are of increasing interest. One such system has been the amphipathic, negatively charged poly(styrene-co-maleic acid) (SMA) polymer to form "SMA Lipid Particles" (SMALPs) which have been widely adopted to solubilize membrane proteins directly from the cell membra
This chapter explores the facilitation of reflective practice to aid and guide educators seeking to develop these soft skills and to assist them in developing educational programmes in the international classroom. Knowledge about learning, teaching, and education is a basic requirement. Few institutions, if any, would dispute the need for teaching staff to have an inventory of skills and expertise
Enzyme-responsive hydrogels, formed by step growth photopolymerization of biscysteine peptide linkers with alkene functionalized polyethylene glycol, provide interesting opportunities as biomaterials and drug delivery systems. In this study, we developed stimuli-responsive, specific, and cytocompatible hydrogels for delivery of anti-inflammatory drugs for the treatment of inflammatory skin disease
In 1968, Swedish insurance company Folksam launched the information campaign Front mot miljöförstöringen (“Front against Environmental Degradation”). The campaign culminated in 1969 with large public hearings where young people addressed local politicians and industry leaders about environmental problems. Throughout this campaign, the aim was to activate youth and make them co-creators of large-sc
Clinical pain is often linked to poor body mechanics, with individuals sometimes presenting multiple painful disorders. Such disorders may be influenced by behaviors that affect the general resiliency and health of the musculoskeletal system. We aimed to develop a self-reported scale using the Malmö Diet and Cancer Study questions on work-related body mechanical exposures. An expert panel identifi
The release of inorganic elements, especially K, Cl, and S, can cause severe damage to biomass conversion devices, such as slagging, fouling, or corrosion. A predictive model for the release of K-Cl-S elements can be used to enhance the design and operating conditions of biomass conversion devices. In this study, a detailed model is developed that includes 12 solid species and 13 reactions, which
Multiplanet systems are valuable arenas for investigating exoplanet architectures and comparing planetary siblings. TOI-1246 is one such system, with a moderately bright K dwarf (V = 11.6, K = 9.9) and four transiting sub-Neptunes identified by TESS with orbital periods of 4.31, 5.90, 18.66, and 37.92 days. We collected 130 radial velocity observations with Keck/HIRES and TNG/HARPS-N to measure pl
