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Tapasin is a subunit of the transporter associated with antigen processing (TAP). It associates with the major histocompatibility complex (MHC) class I. We show that tapasin interacts with beta- and gamma-subunits of COPI coatomer. COPI retrieves membrane proteins from the Golgi network back to the endoplasmic reticulum (ER). The COPI subunit-associated tapasin also interacts with MHC class I mole
BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measure
OBJECTIVES: Stroke is a serious complication in patients with acute type A aortic dissection (ATAAD). Previous studies investigating stroke in ATAAD patients have been limited by small cohorts and have shown diverging results. We sought to identify risk factors for stroke and to evaluate the effect of stroke on outcomes in surgical ATAAD patients. METHODS: The Nordic Consortium for Acute Type A Ao
3-Methyl-1,2,3-butanetricarboxylic acid (MBTCA) is a secondary organic aerosol and can be used as a unique emission marker of biogenic emissions of monoterpenes. Seasonal variations and differences in vegetation cover around the world may lead to low atmospheric MBTCA concentrations, in many cases too low to be measured. Hence, an important
Purpose: A cost minimisation analysis compares the costs of different interventions’ to ascertain the least expensive over time. We compared different prostate targeted drug treatments with TURP to identify the optimal cost saving duration of a medical therapy for symptomatic benign prostatic enlargement (BPE). Methods: The Evolution registry is a prospective, multicentre registry, conducted by th
BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be liv
Abstract in Undetermined Fallstudier och användartester; Rörelsehinder; Etik - juridik - ekonomi - tillgänglighet; Synskador och blindhet; Äldre personer; Vardagsteknik
Intellectual property is a very important type of asset in today’s business world. Since business in the Western World grows increasingly based and dependent on know-how and technological development, intangible assets such as trademarks, copyrights and patents plausibly represent greater economic value to economic actors here than other, physical, assets do. Although it is comparatively unknown
BACKGROUND: The need for equivalent results of routine measurement procedures for the alcohol biomarker carbohydrate-deficient transferrin (CDT) has been recognized by the IFCC. This article describes a project to harmonize CDT as conducted by an IFCC working group initiated for this purpose. METHODS: We used procedures for achieving harmonization as developed by the Consortium for Harmonization o
A combined search for the Standard Model Higgs boson with the ATLAS experiment at the LHC using datasets corresponding to integrated luminosities from 1.04 fb(-1) to 4.9 fb(-1) of pp collisions collected at root s = 7 TeV is presented. The Higgs boson mass ranges 112.9-115.5 GeV, 131-238 GeV and 251-466 GeV are excluded at the 95% confidence level (CL), while the range 124-519 GeV is expected to b
The purpose of this study is to examine the international legal instruments specifically addressing the practice of enforced disappearance and analyse if they are sufficient in relation to the gravity and seriousness of the crime. The instruments examined are: the International Convention for the Protection of All Persons from Enforced Disappearance, the Inter-American Convention on Forced Disappe
Voluntary carbon markets (VCM) have grown significantly over the past years. However, the VCM is facing a ‘credibility crisis’ due to governance, technical, and market issues. Notably, despite the significant role of credibility in the VCM, a lack of systematic assessment frameworks in this area is discerned. To address this knowledge gap, this thesis set out to build, test, and evaluate a framewo
IntroductionHealth-related quality of life (HRQoL) is essential for human wellbeing, influenced by a complex interplay of factors, and is reported lower in women than men. We aimed to evaluate which factors were the most important for HRQoL in a middle-aged general population.MethodsThis was a cross-sectional, multi-centre study of 29,212 men (48%) and women (52%) aged 50–64 in the general populat
Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportio
The AI Commission prescribed a governance model, namely centralized leadership, to tackle existing digitalization challenges, as outlined in the Roadmap for Sweden at the end of 2024. This research discussed the implications of the Roadmap for Sweden on welfare governance within the Automated Decision-making (ADM) context as interpreted through a Weberian theoretical and methodological framework.
Replacing fossil fuels with renewable energy sources, such as offshore wind, is crucial to mitigating climate change. The ambitious federal targets on offshore wind set by the United States’s (US) Biden Administration will, however, increasingly impact the 129 million citizens living within local communities in coastal regions. Achieving social acceptance is therefore critical to reaching the US’
LUNDS UNIVERSITET EKONOMI HOGSKOLAN Protokoll 2024-02-22 STYR 2024/43 (EHL) STYR 2023/2434 (LU) Kansli EHL Offentlig sarnrnanraknlng av elektroniska roster gallande val av Ekonomihogskolans ledarnoter i universitetskollegiet for perioden 2024-03-01 - 2027-12-28 Tid och plats for sarnmanrakning: 2024-02-22 kl. 10:00, EC3:318 Narvarande Kanslichef Alf Rosenback, ordforande Rostraknare: Margareta Da
Introduction A World Health Organization (WHO) system has recently been introduced to standardize reporting of lymph node fine-needle aspiration biopsy (LN-FNAB) cytopathology. Herein, we analyze its diagnostic performance in a routine setting.Materials and methodsWe reviewed 2274 consecutive lymph node fine-needle aspiration biopsies categorized according to the WHO system. Corresponding histolog
The Antikythera Wreck represents a unique example of implementation and development of technological methods and systems aiding archaeological research. Since 1900, when the wreck was discovered, the challenges posed by the underwater environment and the variety of archaeological data hidden in the multifarious artifacts has been yielding great opportunities for technological innovation. Research
