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The bacterial superantigen staphylococcal enterotoxin A (SEA) is a potent inducer of cytokine production and cytotoxic T cell responses. To target a T cell attack against tumor cells we have genetically engineered a fusion protein of SEA and the Fab part of the tumor-reactive mAb C215. Injection of this Fab-SEA fusion protein to mice carrying lung metastases of the poorly immunogenic B16 melanoma
Objective: The etiology of abdominal aortic aneurysm (AAA) includes atherosclerotic, inflammatory, immunological and coagulatory mechanisms. The aim of this study was to evaluate associations between markers for some of these mechanisms and AAA-size, in order to identify markers which might later be evaluated in relation to aneurysm growth. Material and methods: Prospectively 360 AAA-patients and
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It is shown that the ternary system heavy water-heptane-hexadecyl hexaethylene oxide (C16E6) has a stable bicontinuous microemulsion phase down to an exceptionally low concentration at the balanced temperature of 26.8 °C. It is further demonstrated that the ambient gravitational field has an influence on the observed phase equilibria for typical sample sizes (∼1 cm). Direct measurements using a nu
Mediators are often thought to be more effective if they are unbiased or have no preferences over the issue in dispute. In addition, impartiality is a traditional feature attributed to the mediator. This study presents comparative analysis of small state and great power mediation which highlights a contrary logic. With the help of a contingency approach, combined with a model of mediation drawn on
Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate signaling molecule for exocytosis in neuroendocrine cells. In pancreatic beta-cells, glucose acutely raised the NADPH-to-NADP(+) ratio and stimulated insulin release in parallel. Furthermore, intracel
Coordination of Official Development Assistance (ODA) has been an important topic in debates focused on improving the outcomes of international development. The subject assumes particular importance with the expected increase of ODA flows to support developing countries addressing climate change-related issues. The case of Mozambique is of special relevance due to the heightened consequences of cl
Denna uppsats undersöker de sedvanerättsliga reglerna om immunitet för statschefer och andra högt uppsatta statsrepresentanter. Syftet är att göra en övergripande kartläggning av reglernas innehåll som möjliggör korrekt rättstillämpning i framtiden. Genom att granska konventioner, kodifieringar, rättsfall och doktrin om ämnet, samt genom att undersöka det pågående kodifikationsarbetet, kartläggs rThis essay examines the rules of immunity for heads of state and other high-ranking state officials under international law. The aim is to create a comprehensive outline of the content of the rules, enabling a more accurate and legal-ly sound practice in the future. Through reviewing conventions, codifications, legal cases and legal doctrine on the subject, and through examining the current codi
The research takes a descriptive and exploratory approach in understanding how the risk experience of top athletes shapes sports entrepreneurs’ risk-handling strategies. In particular, the purpose of this study is to advance the theoretical knowledge of entrepreneurial risk-handling by studying risk-handling strategies developed and applied by sports entrepreneurs and putting them into a conceptua
Background: In contrast to typical measures employed to assess outcomes in healthcare such as mortality or recovery rates, it is difficult to define which specific outcomes of care are the most important in caring for dying individuals. Despite a variety of tools employed to assess different dimensions of palliative care, there is no consensus on a set of core outcomes to be measured in the last d
