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Background Acute pyelonephritis is a common infection in adult women, but there is a paucity of controlled trials of its treatment and the optimum duration of antibiotic treatment has not been properly defined. We compared the efficacy of ciprofloxacin for 7 days and 14 days in women with community-acquired acute pyelonephritis. Methods In a prospective, non-inferiority trial undertaken at 21 cent

The ALICE Collaboration reports measurements of the large relative transverse momentum (kT) component of jet substructure in pp and Pb-Pb collisions at center-of-mass energy per nucleon pair sNN=5.02 TeV. Enhancement in the yield of such large-kT emissions in head-on Pb-Pb collisions is predicted to arise from partonic scattering with quasiparticles of the quark-gluon plasma. The analysis utilizes

Background and importance: The major risk factor for vermilion lip squamous cell carcinoma (vlSCC) is excessive sunlight exposure. Population-based studies on treatment and outcome are lacking. Methods: This is a nation-wide, population-based study of treatment and outcome from prospectively recorded data for 2,111 vlSCC registered in the Swedish Head and Neck Cancer Register (SweHNCR) diagnosed 2

Persistent physical symptoms (PPS) are common, disabling, and associated with high health care use, yet effective and scalable psychological treatments remain limited. Internet-administrated self-help programs may improve access to care. Asynchronous Internet-administered Emotional Awareness and Expression Therapy (I-EAET) with therapist guidance has been shown to reduce somatic symptoms in PPS, b

Background: Optimal long-term follow-up (LTFU) care for survivors of childhood, adolescent and young adult (CAYA) cancer can improve or maintain their quality of life by prevention and early treatment of late effects. However, optimal LTFU care is not provided to all CAYA cancer survivors. This systematic review sought to identify associated barriers, facilitators and other factors of LTFU care fo

BACKGROUND: Peptic gastroduodenal stenosis is a rare but disabling condition causing gastric outlet obstruction. This study aimed to evaluate endoscopic balloon dilation in terms of treatment effectiveness, durability, and identify potential early predictors of unsatisfactory outcomes.METHODS: We conducted a retrospective cohort study of patients who underwent endoscopic balloon dilation for sympt

Introduction: Radiographic progression-free survival (rPFS) by Prostate Cancer Working Group (PCWG) criteria is a radiographic endpoint. The automated bone scan index (aBSI) quantifies osseous disease burden on bone scintigraphy as a percentage of total skeletal weight. Using the aBSI, we sought to quantify increase in tumor burden represented by PCWG progression criteria, and to determine the int

This study investigates particulate matter (PM) and regulated emissions from renewable rapeseed oil methyl ester (RME) biodiesel in pure and blended forms and contrasts that to conventional diesel fuel. Environmental and health concerns are the major motivation for combustion engines research, especially finding sustainable alternatives to fossil fuels and reducing diesel PM emissions. Fatty acid

Background: HIV self-testing (HIVST) has been found to have high acceptability among men who have sex with men (MSM) internationally and might contribute to increase testing frequencies, but many countries, including Sweden, lack policies for using HIVST. Objective: To examine interest to use and willingness to pay for HIVST, and associated factors, among MSM attending HIV testing venues in Sweden

Purpose: The aim of this study was to develop and validate an artificial intelligence (AI)-based method using convolutional neural networks (CNNs) for the detection of pelvic lymph node metastases in scans obtained using [18F]PSMA-1007 positron emission tomography-computed tomography (PET-CT) from patients with high-risk prostate cancer. The second goal was to make the AI-based method available to

Registered nurses with a doctoral degree are important for the quality of care, nursing education, and nursing research. Still, postgraduate career paths are criticized for being too vague. To enable career path development, mapping of the current situation appears fundamental. The objective was therefore to chart the current professional positions and work conditions and to explore the future car

Drug side effects (DSEs) or adverse drug reactions (ADRs) are a major concern in the healthcare industry, accounting for a significant number of annual deaths in Europe alone. Identifying and predicting DSEs early in the drug development process is crucial to mitigate their impact on public health and reduce the time and costs associated with drug development. Objective: In this study, our primary

Objectives To investigate the relation between patient characteristics at rheumatoid arthritis (RA) diagnosis and subsequent initiation of treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) or targeted synthetic DMARDs (tsDMARDs). Design A retrospective cohort study. Setting and participants Consecutive patients (N=330) with early RA (symptom duration <12 months) diagnosed at

Stress-related health problems have increased sharply over the last two decades and have become a serious issue at all levels of society. In the Jönköping Region in southern Sweden, a nature-based rehabilitation (NBR) program for adults with Exhaustion Syndrome has been developed and then implemented into the Swedish National Healthcare System. The main aim of this study was to investigate the eff

BACKGROUND: Behavioural therapy for tics is difficult to access, and little is known about its effectiveness when delivered online.OBJECTIVE: To investigate the clinical and cost-effectiveness of an online-delivered, therapist- and parent-supported therapy for young people with tic disorders.DESIGN: Single-blind, parallel-group, randomised controlled trial, with 3-month (primary end point) and 6-m

A search for the leptonic charge asymmetry (Acℓ) of top-quark-antiquark pair production in association with a W boson (tt¯ W) is presented. The search is performed using final states with exactly three charged light leptons (electrons or muons) and is based on s = 13 TeV proton-proton collision data collected with the ATLAS detector at the Large Hadron Collider at CERN during the years 2015–2018,