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Adjuvant bacillus Calmette-Guérin (BCG) instillations represent a cornerstone in the treatment of non–muscle-invasive bladder cancer. Instillation schedule and dose modifications have been evaluated in efforts to reduce the incidence of adverse events (AEs), but none so far has the same treatment efficacy as the full-dose recommended schedule. It has been shown that prophylactic quinolone use in c
Background COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world. Effective treatments of COVID-19 are urgently needed. This is the second edition of a living systematic review of randomized clinical trials assessing the effects of all treatment interventions for participants in all age groups with COVID-19. Methods and findings
Background/aim: In ED chest pain patients, a 0-hour/1-hour protocol based on high sensitivity cardiac troponin T (hs-cTnT) tests combined with clinical risk stratification in diagnosing acute coronary syndrome is recommended. Two of the most promising risk stratification tools are the History, ECG, Age, Risk Factors and Troponin (HEART) and Emergency Department Assessment of Chest Pain (EDAC) scor
OBJECTIVE: To evaluate compliance to workflow and accuracy of tests in Sweden's first fast-track referral pathway for patients with nonspecific symptoms and suspected cancer (SCAN).DESIGN: Prospective cohort study with consecutive inclusion of patients referred to the diagnostic center (DC).SETTING: Patients with nonspecific symptoms were examined in primary care according to a protocol including
Background. In Sweden, both glucose analyzers in accredited laboratories and point-of-care glucose devices are used for gestational diabetes mellitus (GDM) diagnosis. The aim of this study was to compare the diagnostic performance of the HemoCue Glucose 201+ (HC201+) and RT (HC201RT) systems with that of the hospital central laboratory hexokinase method (CL) based on lyophilized citrate tubes, usi
Patients with diffuse large B-cell lymphoma (DLBCL) who fail to complete planned treatment with R-CHOP due to toxicity are sparsely described. We investigated the extent of failure to complete treatment (six cycles or more, or three cycles + RT for patients with stage I disease) with R-CHOP for reasons unrelated to non-response, the determinants of such failure and the outcome among these patients
Introduction This study aims to clarify the role(s) of endogenous sex hormones to influence health outcomes in men, specifically to define the associations of plasma testosterone with incidence of cardiovascular events, cancer, dementia and mortality risk, and to identify factors predicting testosterone concentrations. Data will be accrued from at least three Australian, two European and four Nort
Purpose: To investigate access to basic human rights such as health, a standard of living adequate for health, education, work, marrying and establishing a family, and voting for prosthetic and orthotic users with lower limb disabilities in Malawi. Materials and methods: A cross-sectional design and a questionnaire were used to collect data from 83 participants. Results: Most participants reported
It is normally assumed that induced transitions, by e.g. hyperfine, magnetic field or spin interaction, arise due to mixing in the upper levels. In this paper we discuss an example when mixing in the lower levels through an externally applied magnetic field gives rise to a magnetic field induced transition. We discuss the theory for such a transition and give an example from Fe X, which is relevan
Background Rectal bleeding is considered an alarm symptom for colorectal cancer (CRC) but it is common and mostly caused by benign conditions. Qualitative faecal immunochemical tests (FITs) for occult blood have been used as diagnostic aids for many years in Sweden when CRC is suspected. The study aimed to evaluate the usefulness of FITs requested by primary care physicians for patients with and w
Retinal implant devices are becoming an increasingly realizable way to improve the vision of patients blinded by photoreceptor degeneration. As an electrode material that can improve restored visual acuity, carbon nanotubes (CNTs) excel due to their nanoscale topography, flexibility, surface chemistry, and double-layer capacitance. If vertically aligned carbon nanotubes (VACNTs) are biocompatible
Purpose: The purpose of the thesis is to critically review different pricing strategies with a special focus on Revenue Management and discuss the possibilities and challenges for hotels when optimising their profitability. Methodology: We have conducted three case studies on hotels located in the Öresund region. The studies were done with a qualitative research approach. The respondents are all w
In pursuit of energy efficiency and sustainable development, goals have been set by the EU and Sweden to improve the energy performance of buildings and reduce their environmental impact. Renovating the existing building stock is a path to achieving the energy and climate goals. This study investigates and analyses various retrofitting options for multifamily residential buildings in Skåne, Sweden
With an increase in temperature (T) and a change in precipitation (P) patterns due to climate change, global conditions for tree growth are changing and shifting. While some areas experience an increase in P, favoring tree growth, many regions are also predicted to show a decrease in P, leading to trends of desertification. This study examines the projected climate change in Nigeria, located in Su
Sexual and Reproductive Health and Rights (SRHR) is suggested to be solved by policies and action plans. However, post-structural scholars argue that discourses shape policies, and their solutions. The policy discourse on women with disabilities’ SRHR needs has not been given much attention, especially in the context of Africa. Therefore, this study questions how SRHR is represented in relation to
The discovery of the Higgs boson h in 2012 further confirmed the remarkable accuracy of the Standard Model (SM). Despite this, some compelling excesses in multi-lepton final states were recorded in both major runs of the Large Hadron Collider (LHC). The excesses can be explained by the introduction of a model where a heavy boson X decays into a SM Higgs boson h and a singlet scalar S with Higgs-li
What was the outcome of Sweden’s fiscal policy between 2009 and 2012 and why was it different from forecasts? Research by the OECD during the financial crisis, used by the Swedish Government to illustrate their fiscal policy, suggested that Sweden would have the biggest stimulus of all OECD countries. However, Sweden’s fiscal policy ended up rather modest. By examining the forecasted fiscal policy
Human-wildlife conflicts threaten the existence of many species worldwide. Large carnivores are often involved in such conflicts due to their diets and expansive home ranges. In Finland, wolf (Canis lupus) is one of such conflict-prone species. The wolf conflict is a multifaceted issue stemming for instance from fears, damages to domestic animals, competition for game and opposition of EU wildlife
