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In animal models of Parkinson's disease, striatal overactivation of ERK1/2 via dopamine (DA) D1 receptors is the hallmark of a supersensitive molecular response associated with dyskinetic behaviors. Here we investigate the pathways involved in D1 receptor-dependent ERK1/2 activation using acute striatal slices from rodents with unilateral 6-hydroxydopamine (6-OHDA) lesions. Application of the dopa

Popular Abstract in English Universal Burdens There are Zen students who are in chains when they go to a teacher, and the teacher adds another chain. The students are delighted, unable to discern one thing from another. This is called 'a guest looking at a guest.' -Linji What do Zen master Linji, Muslim scholar ‘Abbād ibn Sulaymān, and Comanche thinker Parra-Wa-Samen have in common? Among manyZen Buddhists have long given the following advice to attain liberation: “Eat when you’re hungry. Sleep when you’re tired.” In other words: “Freedom” is the “knowledge of necessity” (Hegel, Marx, and Engels). Early Islamic communities dealt with the challenge of internal warfare and tyranny and concluded that, “sixty years of tyranny is better than one day’s anarchy.” In other words, the worst-cas

Acquired chromosome abnormalities in tumours often reflect pathogenetic events at the gene level. Multicolour fluorescence in situ hybridisation (FISH) with single-copy probes offers extensive possibilities to characterise chromosome breakpoints in relation to the physical map of the human genome. This approach is based on the construction of comprehensive EST- based maps, combinatorial labelling

Background Families with parental intellectual disabilities (ID) are likely to need support in achieving a decent family life. In order to accurately plan for such support services, society needs data regarding the occurrence of those parents and their children. The aim of this study was to investigate the 5-year incidence of children born to women with ID in a county in Sweden. Methods Women born

The article analyses the stormy debate in Poland caused by the publication in 2000 of Neighbors, a book written by the Polish-born American scholar Jan Gross. The book, that deals with the war-time mass murder of the Jewish population in the Polish town Jedwabne, encouraged by the Nazi Germans but perpetrated by local Poles, brought about shock and created a challenge to Polish collective memory.

Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the abCarbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the ab

Endoglucanases (endo-1,4---glucan-4-glucanohydrolase, EC 3.2.1.4) are industrially important enzymes. In this study endoglucanase I (EGI or Cel7B) of the filamentous fungi Trichoderma reesei has been genetically engineered to investigate the influence of tryptophan rich peptide extensions (tags) on partitioning in an aqueous two-phase model system. EGI is a two-domain enzyme and is composed of a N

For Rb 87 the level crossing method was applied to the first four levels ( n = 5, 6, 7, and 8) of the np 2 P 3/2 series in the Rb I spectrum. By using magnetic dipole interaction constants from corresponding zero field optical double resonance experiments, the electronic g J factors of 5, 6, and 7 p 2 P 3/2 were calculated from the level crossing data. For these levels the natural radiative lifeti

Popular Abstract in English Marcel Duchamp (1887-1968) is an artist who has strongly influenced how art is currently understood. He aimed at broadening the concept of art and suggested that other things than paintings and sculptures could be defined as art. The thesis concerns Duchamp’s permanent installation Étant donnés: 1° La chute d’eau, 2° Le gaz d’éclairage (Given: 1. The Waterfall, 2. The IAims: To study aspects of Marcel Duchamp’s posthumous permanent installation 'Étant donnés: 1° La chute d’eau, 2° Le gaz d’éclairage…' ('Given: 1. The Waterfall, 2. The Illuminating Gas...'). To investigate and show methods in the making as well as in the interpretation of Duchamp’s work. To perform and document minor actions as reflections on (and of) the study. To investigate relations between r

För att polisen ska kunna fullgöra sina uppgifter finns det en laga befogenhet att använda våld. I de fall då våld används kan det ibland vara nödvändigt för polisen att använda sig av hjälpmedel, vilket skjutvapen har varit för poliser i yttre tjänst sedan år 1965. Regleringen för när en polisman har laga befogenhet att använda skjutvapen är idag dock kritiserad för att vara svårläst, ogenomtänkt

Abstract In this thesis the EP’s role and influence in the development of the co-decision procedure is analysed. Over the last decades the European Parliament has increased its power in the legislative process. It has been one of the central actors in the development of the co-decision procedure, established in the Maastricht Treaty and extended in the Amsterdam Treaty. The question of how the EP

Uppsatsen handlar om vilken betydelse etablerade regionala resurser har för lokaliseringen av ny industriverksamhet. Som exempel används biltillverkaren National Electric Vehicle Sweden (NEVS) etablering i Trollhättan. Med resurser åsyftas arbetskraft, underleverantörer, kapital och infrastruktur. År 2011 gick biltillverkaren Saab Automobile i konkurs och i slutet av sommaren 2012 köpte Nevs konku