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Huntington's disease (HD) is caused by an expanded polyglutamine tract in the protein huntingtin (htt). Although HD has historically been viewed as a brain-specific disease, htt is expressed ubiquitously, and recent studies indicate that mutant htt might cause changes to the immune system that could contribute to pathogenesis. Monocytes from HD patients and mouse models are hyperactive in response
Abstract in Undetermined Acoustic phonons are studied in finite nanowires based on the elastic continuum model. The phonon dispersion relations are compared for different types of approximations both for pure nanowires and nanowire heterostructures including cubic and wurtzite materials. We find that the isotropic approximation highly underestimates the frequency of torsional modes. The impact of
Many neurons typically fire action potentials in brief, high-frequency bursts with specific consequences for their synaptic output. Here we have examined short-term plasticity engaged during burst activation using electrophysiological recordings in acute rat hippocampal slices. We show that CA3-CA1 glutamate synapses exhibit a prominent depression of presynaptic release probability for approximate
In this paper youth representation among Swedish local government politicians is examined. Although youth people (18-29 years) constitute 20% of the electorate only about 7 percent of the politicians are young. This means youths are represented at a quota of 37% compared to the other age groups that average at least 100%. The study aims to fins explanations in terms of individual resources and pol
This paper aims to examine whether the Federal Communications Commission’s (FCC) debate during 2017 regarding the bill “Restore internet Freedom” can be understood through a theoretical neo-liberal and social-liberal ideological perspective. The purpose of this paper is to clarify and bring an understanding of what was said in the debate regarding the bill, by trying to interpret what political id
In recent years there has been a large increase in available data from the electric grid in Finland. The availability of both operational as well as financial data enables exploration of forecasting energy prices using deep learning techniques. As a result this thesis implements the Multi-Horizon Quantile Recurrent Neural Network (MQRNN) to forecast the regulating price in the Finnish energy marke
The Oxytocin Me! project has proven to be a response to the nowadays increasing focus on high technology. The topic I have chosen is both a health and social matter: stress. In this regard, I have developed a stress relieving product that should challenge people to use their body’s own natural resources. The result is an ergonomic hug cushion that should stimulate the body to produce oxytocin hor
Sanctions have become a frequently used tool of political interactions around the globe, and the U.S. is he leading countries when it comes to imposing economic sanctions. While the intention of economic sanctions is to put pressure on the target to alter its behaviour, research has shown that economic sanctions can have negative effects even on the sender country. Utilising a difference-in-differ
This paper investigates the role of ethnicity in regional economic divergence across the Mexican states based on each state’s overall access to government services such as education, public infrastructure and healthcare based on the latest available data. The paper uses Mexico as a case study using the country’s three main ethnicities (Indigenous, Mestizo and European) as dependent variables for r
This master thesis explores the Corporate Sustainability Due Diligence Directive (CSDDD) within the European Union, focusing on how it integrates the concept of double materiality into corporate governance. The directive mandates that companies not only account for the financial impact of sustainability on their operations but also consider their broader environmental and societal effect. This stu
Foreign Direct Investment (FDI) is a part of the globalization process, a process increasing all over the world. These investments affect people, both in the home economy and the host economy. People in the host economy are, due to several aspects, affected in different ways. One of those aspects is gender. Gender inequality in the world is well known, women have less political, economic and socia
Since the Dawn of Man the metallic iron has been a giant issue for the daily life of humans by using for developments and generality prosper. This "hot" metal is still the most wanted and needed metal for all mankind. Sandvik Mining and Construction has for the last ten years increased our knowledge for the development for crushers, crushing and crusher automation and we have created new frontiers
In the early era of transplantation, it was common practice to exclude diabetic patients since the outcome in such cases was usually poor. At our center in Malmö, Sweden, diabetic nephropathy was never regarded as a contraindication. During the 22-year period from 1972 to 1993, 223 renal allografts were transplanted in 189 uremic diabetics, representing 24% of all renal transplant recipients (n =
We investigate the potential of different pre-fetching and/or caching strategies for different user behaviour with respect to surfing or browsing in a catch-up-TV network. To this end we identify accounts and channels associated with strong or weak surfing or browsing respectively and study the distributions of hold times for the different types of behaviour. Finally we present results from a requ
For nearly three decades, spatial games have produced a wealth of insights to the study of behavior and its relation to population structure. However, as different rules and factors are added or altered, the dynamics of spatial models often become increasingly complicated to interpret. To tackle this problem, we introduce persistent homology as a rigorous framework that can be used to both define For nearly three decades, spatial games have produced a wealth of insights to the study of behavior and its relation to population structure. However, as different rules and factors are added or altered, the dynamics of spatial models often become increasingly complicated to interpret. To tackle this problem,we introduce persistent homology as a rigorous framework that can be used to both define a
Bookshops are one of the most visible places for books in public space. No bookshop can ever offer every book available; rather it is in its selection that each bookshop is unique. Value, writes Michael Bhaskar in Curation (2016), no longer resides in access, but in curation—in selecting and arranging. The article argues that curating practices in bookshops can be mapped from four main aspects: sp
This review summarizes the involvement of vitamin K and the extrahepatic Gla proteins matrix Gla protein (MGP), Os-teocalcin (OC) and growth arrest-specific gene 6 protein (Gas6) in the development and progression of diabetes: in particular, complications related to angiopathy and inflammation. High vitamin K intake has been associated with a decreased risk of type 2 diabetes. Furthermore, in typeThis review summarizes the involvement of vitamin K and the extrahepatic Gla proteins matrix Gla protein (MGP), Os-teocalcin (OC) and growth arrest-specific gene 6 protein (Gas6) in the development and progression of diabetes: in particular, complications related to angiopathy and inflammation. High vitamin K intake has been associated with a decreased risk of type 2 diabetes. Furthermore, in type
