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Gaussian wave models have been successfully used since the early 1950s to describe the development of random sea waves, particularly as input to dynamic simulation of the safety of ships and offshore structures. A drawback of the Gaussian model is that it produces stochastically symmetric waves, which is an unrealistic feature and can lead to unconservative safety estimates. The Gaussian model des
We present an algorithm for the computation of the stress field around a branched crack. The algorithm is based on an integral equation with good numerical properties. Our equation is obtained through a left regularization of an integral equation of Fredholm's first kind. Complex valued functions involving repeated products of square roots appear in the regularization. A new and effective scheme f
The hallmark of severe haemophilia, defined as a circulating level of factor (F) VIII (haemophilia A cases) or FIX (haemophilia B cases) of < 1%, is recurrent bleeding into muscles and joints (haemarthroses) from an early age of life. The inevitable result of such bleeding is progressive joint damage, leading to disabling arthritis that is typically evident within the first 2 decades of life in pe
The performance of the ALICE detector in searches for new heavy stable charged particles in pp collisions is discussed in this paper Gluino R-hadron was chosen as an example of a candidate, and cross sections and kinematic properties were obtained from PYTHIA simulations for various gluino masses (100 - 500 GeV/c(2)) Detector response simulations for R-hadrons in the TPC acceptance (vertical bar e
The interactions between wild-type or mutant recombinant forms of human cystatin C and rat cathepsin B were characterized by measuring progress curves for substrate hydrolysis in the presence of inhibitor. The investigation was guided by the use of computer modeling and explores the possibility that amino acid residues in the N-terminal region of cystatin C interact with substrate-binding regions
We present a method for parametrizing the Zeeman effect in hydrogen-like systems in high-temperature plasmas, where the fine-structure is completely unresolved. The method is based on the observation that the different polarization components behave collectively like separate entities, with simple relations. The entire Zeeman pattern can then be reduced to just three components, whose dependence o
Through ethnographic accounts, the method of heat treatment of silica materials to improve the flaking qualities is shown to have been known almost worldwide. Some mesolithic and neolithic flint artifacts from southern Sweden were examined in order to determine if they too were heat treated. From several methods proving or indicating thermal alteration of flint, analysis using scanning electron mi
The present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxylase-positive neurons was not reduced and nigrostriatal connectivity remained intact in 16-week-old R6/1 mice, the size of tyrosine hydroxy
The brackish water cyanobacterium Nodularia spumigena produce the hepatotoxic cyclic pentapeptide nodularin. Intoxications for both human as well as animal may arise when water reservoirs are contaminated with potentially toxic Nodularia species. Here, results of three independent methods for the determination of nodularin in different strains of N. spumigena are presented. The results obtained wi
Consider a parametrized family of general hidden Markov models, where both the observed and unobserved components take values in a complete separable metric space. We prove that the maximum likelihood estimator (MLE) of the parameter is strongly consistent under a rather minimal set of assumptions. As special cases of our main result, we obtain consistency in a large class of nonlinear state space
We investigate Newton's method for complex polynomials of arbitrary degree d, normalized so that all their roots are in the unit disk. For each degree d, we give an explicit set S-d of 3.33d log(2) d(1 + o(1)) points with the following universal property: for every normalized polynomial of degree d there are d starting points in S-d whose Newton iterations find all the roots with a low number of i
We present results from a search for gravitational-wave bursts in the data collected by the LIGO and Virgo detectors between July 7, 2009 and October 20, 2010: data are analyzed when at least two of the three LIGO-Virgo detectors are in coincident operation, with a total observation time of 207 days. The analysis searches for transients of duration less than or similar to 1 s over the frequency ba
New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system lesions in space and time has been simplified, and in some circumstances dissemination in space and time can be established by a single scan. These revisions simplify the Criteria, preserve their diagnos
We present the FERRUM Project, an international collaboration aiming at a production and evaluation of oscillator strengths (transition probabilities) of selected spectral lines of singly ionized iron group elements, that are of astrophysical relevance. The results obtained include measurements and calculations of permitted and forbidden lines of Fe II. The data have been applied to both emission
In this paper we describe an image-based approach to finding location-based information from camera-equipped mobile devices. We introduce a point-by-photograph paradigm, where users can specify a location simply by taking pictures. Our technique uses content-based image retrieval methods to search the web or other databases for matching images and their source pages to find relevant location-based
A method for calculating the wave load induced fatigue damage accumulated by a vessel sailing along the North Atlantic route (NAr) is presented. This method is based on the Palmgren-Miner additive rule and the rainflow cycle (RFC) count. For simplicity, the load the vessel experiences is assumed to be proportional to the encountered significant wave height process, H-s. The asymptotically normal c
OBJECTIVES: Neutrophils are activated and infiltrate the myocardium after ischemia and reperfusion. The involvement of neutrophils in irreversible reperfusion injury is suggested by numerous experimental studies. The aim of this study was to investigate markers of neutrophil activation following reperfusion of acute myocardial infarction (AMI) accomplished with percutaneous coronary intervention (
We study the rapid decrease of peak gain in resonant-phonon THz Quantum Cascade Lasers with increasing temperature. The effect of various microscopic scattering processes on the gain profile as a function of temperature is discussed. We argue that increased broadening, prim arily due to increased impurity scattering, and not diminishing population inversion, is the main reason for the reduction o
This study investigates the size and power properties of three multivariate tests for autocorrelation, namely portmanteau test, Lagrange multiplier (LM) test and Rao F-test, in the stable and unstable vector autoregressive (VAR) models, with and without autoregressive conditional heteroscedasticity (ARCH) using Monte Carlo experiments. Many combinations of parameters are used in the simulations to
