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The search for drugs that modulate NMDA receptors has been very active in the latest decades since they play a pivotal role in neuronal death and in several neurological conditions, including stroke, traumatic brain injury, and neurodegenerative diseases. Activating the receptor evokes an entry of calcium into the neuron, thus leading to a rapid depolarization that can be measured using electrophy
Ethylene is one of the most important products in the emissions-intensive petrochemical industry. Decarbonizing the ethylene industry is thus important for achieving global carbon neutrality. This study is the first to explore future long-term zero-emissions production pathways for the ethylene industry in China, the world's biggest ethylene producer. An optimization model was built in the context
In this Perspective, we discuss thermal imbalance and the associated electron-mediated thermal transport in quantum electronic devices at very low temperatures. We first present the theoretical approaches describing heat transport in nanoscale conductors at low temperatures, in which quantum confinement and interactions play an important role. We then discuss the experimental techniques for genera
In this paper, a factor-augmented version of the New Keynesian Phillips curve (NKPC) is assessed using a data set comprised of a large panel of European Union (EU) member countries. The factor-augmentation is natural given that country-level inflation rates are highly co-moving. The presence of unattended common factors is important because it raises the issue of omitted variables bias, as the rea
The introduction of autonomous machines (AMs) in human domains has raised challenging questions about the attribution of responsibility; referred to as the responsibility gap. In this paper, we address the gap by arguing that entities should not be granted the freedom of action unless they can also recognise the same right for others—and be subject to blame or punishment in cases of undermining th
Microbial, algal, plant and animal cells have been immobilized, with preserved viability, by entrapment in various matrices according to a new bead polymerization technique. The cell polymer/monomer mixture is kept suspended in a hydrophobic phase such as soy, paraffin, or silicon oil, tri-n-butylphosphate, or dibutyphtalate, which is compatible with the cells. The various monomers or polymers tes
Parkinson's disease (PD) is characterized by the loss of the dopaminergic nigrostriatal pathway which has led to the successful development of drug therapies that replace or stimulate this network pharmacologically. Although these drugs work well in the early stages of the disease, over time they produce side effects along with less consistent clinical benefits to the person with Parkinson's (PwP)
This chapter seeks to explore the intersections between occupational cultures, bystanders, and social justice and inclusion based on the empirical example of policing. Specifically, we pursue the question: what is the role of police officers as bystanders to occupational police culture and how does that influence inclusion? Against the backdrop of occupational culture, we put forth four key aspect
In this paper, we recall Lepowsky's and Wakimoto's product character formulas formulated in a new way by using arrays of specialized weighted crystals of negative roots for affine Lie algebras of type Cl(1), Dl+1(2) and A2l(2). Lepowsky–Wakimoto's infinite periodic products appear as one side of (conjectured) Rogers–Ramanujan-type combinatorial identities for affine Lie algebras of type Cl(1).
The European Union (EU) and the EU member states have adopted a number of policies that can support circular economy developments in the electrical and electronic equipment (EEE) sector, and additional policies have been proposed. The policies include the new Ecodesign Regulation and a new Battery Regulation, and forthcoming rules related to durability and repairability of mobile phones and tablet
This paper introduces a new lifting method for analyzing convergence of continuous-time distributed synchronization/consensus systems on the unit sphere. Points on the d-dimensional unit sphere are lifted to the (d+1)-dimensional Euclidean space. The consensus protocol on the unit sphere is the classical one, where agents move toward weighted averages of their neighbors in their respective tangent
With this paper and the accompanying audio paper, our aim is to explore the juxtaposition of sound and democracy. Recognizing the multifaceted nature of this field, we approach it through the notion of care and an empirical analysis of democratic implications of trying to regulate sound in public spaces. We examine standards as one example of the many attempts to control sound in both public and p
Cellular-based localization and sensing pave the way for a variety ofapplications across various domains, ranging from autonomous driv-ing to emergency care and intelligent traffic management. Althoughtraditional methods have been effective, they still face challenges such as therequirement for highly accurate models and the inherent complexity of thealgorithms. This thesis explores the potential
We study Frege proofs using depth-d Boolean formulas for the Tseitin contradiction on n \times n grids. We prove that if each line in the proof is of size M, then the number of lines is exponential in n/(log M)O(d). This strengthens a recent result of Pitassi, Ramakrishman, and Tan [2022 IEEE 62nd Annual Symposium on Foundations of Computer Science, 2022, pp. 445-456]. The key technical step is a
The chemical industry, essential to economic growth and innovation, faces critical environmental sustainability challenges, notably pollution, emissions, and intensive resource use. Motivated by the need for practical tools to address these issues, this research develops a structured, comprehensive framework to assess and enhance environmental sustainability within the chemical sector. The framewo
The illicit trafficking of cultural heritage represents a significant global challenge, exacerbated by digital technologies that facilitate unauthorised trade while offering new protection opportunities. The ANCHISE project addresses these challenges through a suite of six innovative, complementary tools designed to enhance the detection, prevention, and investigation of cultural property traffick
Background Aortic valve calcification (AVC) is a disease process driven by inflammation and lipid infiltration, serving as a precursor to aortic stenosis. While male sex has been implicated as a risk factor for AVC, sex-specific differences, particularly among younger individuals in the general population, are not well characterised. Methods The Swedish CArdioPulmonary BioImage Study was used, com
Detection of toxic hexavalent chromium in soil, groundwater, industrial effluent, etc., is of significant interest. We demonstrate the electrochemical detection of Cr(VI) using a surface-engineered mesoporous carbon-based material. The mesoporous carbon-based material is obtained by the controlled pyrolysis of a homogenous mixture of Fe and Co complexes of hydrolyzed collagen. The as-synthesized m
