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The German federal state of North Rhine-Westphalia (NRW) is home to one of the most important industrial regions in Europe, and is the first German state to have adopted its own Climate Protection Law (CPL). This paper describes the long-term (up to 2050) mitigation scenarios for NRW's main energy-intensive industrial sub-sectors which served to support the implementation of the CPL. It also descr
Through several decades of research, absolute paleointensity estimates have been obtained from a wide range of rocks with varying ages, covering the last 3.45 Ga years. These paleointensity data are crucial to study the past geodynamo and the geological evolution of the Earth's deep interior. However, paleointensity data are often difficult to interpret, and on-going discussions concerning the pas
Introduction: Assessing left ventricular (LV) systolic function in a rapid and reliable way can be challenging in the critically ill patient. The purpose of this study was to evaluate the feasibility and reliability of, as well as the association between, commonly used LV systolic parameters, by using serial transthoracic echocardiography (TTE). Methods: Fifty patients with shock and mechanical ve
Syftet med uppsatsen är att undersöka om Feldenkrais-metoden kan vara till hjälp i sångutövande, och hur man kan använda Feldenkrais-metoden i sångundervisning. Jag har valt att använda mig av en kvalitativ undersökning där jag utgått från litteratur, en intervju samt deltagande observation ur ett emiskt/etiskt perspektiv. Som sångare eller utövare av något musikaliskt instrument är det av stor vi
With the current climate crisis, it is time to reframe our understanding of active mobility as a solution for short journeys only. When combined with public transport, almost any journey can be an active one. To compete with private automobile travel, public transport must combine the speed of motorised transport, the reliability of dedicated right-of-way services, and the flexibility of active tr
Precipitation and air temperature are key drivers of watershed models. Currently there are many open-access gridded precipitation and air temperature datasets at different spatial and temporal resolutions over global or quasi-global scale. Motivated by the scarcity and substantial temporal and spatial gaps in ground measurements in Africa, this study evaluated the performance of three open-access
Decrease of saline lakes, which comprise 44% of all available lake water, is a major concern. It additionally accelerates the desertification process of the region. Thus, various countries have taken different actions in protecting their lake water levels. The aim of this paper is to assess different strategies directed to tackle the decreased lake water levels in Lake Urmia and the Aral Sea, whic
The occurrence of coprostanol in soil, surface, and groundwater has recently been reported in several studies. Coprostanol indicates the presence of feces from mammals. For this reason, it is important to establish adsorption behavior in different kinds of geologic media. To our knowledge, we present for the first-time adsorption behavior of coprostanol in soil, sediment, and sand and an estimatio
Youth anxiety disorders are common and heterogeneous. The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered tool designed to assess overall anxiety severity, independent of specific symptoms. The thresholds on PARS for the reliable change index (RCI), the minimal clinically important difference (MCID), treatment response, and full and partial remission remain unclear. Using the Cli
We have compared the predictions of ligand-binding affinities from several methods based on end-point molecular dynamics simulations and continuum solvation, i.e. methods related to MM/PBSA (molecular mechanics combined with Poisson-Boltzmann and surface area solvation). Two continuum-solvation models were considered, viz. the Poisson-Boltzmann (PB) and generalised Born (GB) approaches. The non-el
Background: Clinical signs are a core outcome domain for atopic dermatitis (AD) trials. The current lack of standardization of outcome measures in AD trials hampers evidence-based communication. Objective: We sought to provide evidence-based recommendations for the measurement of clinical signs in AD trials and to inform the Harmonising Outcome Measures for Atopic Dermatitis Initiative. Methods: W
Background: Treatment at stroke units is superior to treatment at other types of wards. The objective of the present study is to determine the effect size of stroke unit care in subgroups of patients with stroke. This information might be useful in a formal priority setting. Methods: All acute strokes reported to the Swedish Stroke Register from 2001 through 2005 were followed until January 2007.
We have analyzed decade-long methane flux data set from a boreal fen, Siikaneva, together with data on environmental parameters and carbon dioxide exchange. The methane flux showed seasonal cycle but no systematic diel cycle. The highest fluxes were observed in July–August with average value of 73 nmol m−2 s−1. Wintertime fluxes were small but positive, with January–March average of 6.7 nmol m−2 s
Palmer Drought Severity Index (PDSI) is known as a robust agricultural drought index since it considers the water balance conditions in the soil. It has been widely used as a reference index for monitoring agricultural drought. In this study, the PDSI time series were calculated for nine synoptic stations to monitor agricultural drought in semi-arid region located at Zagros mountains of Iran. Auto
Background: Mutations in the CDH1 and the role of E-cadherin proteins are well established in gastric cancer. Several in silico tools are available to predict the pathogenicity of the mutations present in the genes with varying efficiency and sensitivity to detect the pathogenicity of the mutations. Objective: Our objective was to identify somatic pathogenic variants in CDH1 involved in Gastric Ca
