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The number of publications in the field of chemical cross-linking combined with mass spectrometry (XL-MS) to derive constraints for protein three-dimensional structure modeling and to probe protein-protein interactions has increased during the last years. As the technique is now becoming routine for in vitro and in vivo applications in proteomics and structural biology there is a pressing need to
A new series of 4-arylamino-3-nitrocoumarin analogues (4–18) have been synthesized and characterized by sophisticated spectroscopic techniques (1H NMR, 13C NMR) and mass spectrometry. All the new synthesized compounds were evaluated for their in vitro cytotoxic activity against the human cervix carcinoma cell line (KB-3-1) using resazurin assay with (+)-griseofulvin as the positive control (IC50 =
Objective: In this study, the aim was to compare the performance of four spatiotemporal decomposition algorithms (stICA, stJADE, stSOBI, and sPCA) and parameters for identifying single motor units in human skeletal muscle under voluntary isometric contractions in ultrafast ultrasound image sequences as an extension of a previous study. The performance was quantified using two measures: (1) the sim
The use of charge balance functions in heavy-ion collision studies was initially proposed as a probe of delayed hadronization and two-stage quark production in these collisions. It later emerged that general balance functions can also serve as a probe of the diffusivity of light quarks as well as the evolution of the systems formed in heavy-ion collisions. In this work, we reexamine the formulatio
Forty-two chapters have been structured according to the toxicities in cancer entities, and the late effects and follow-up proposals have been discussed by European and American authors. Cancer diseases in children, adolescents and young adults are treated within specific treatment protocols and can produce different late effects that will have to be cared for by specific follow-up recommendations
Historiska aktörer är långt ifrån frånvarande i historieforskningen. Varje land och varje tidsepok har sin beskärda del av biografier över framstående vetenskapsmän, intellektuella och utbildningsreformatorer. Trots detta är det inte fel att hävda att de teoretiska strömningar som har satt sin prägel på historiska och sociologiska studier av kunskap sedan 1960-talet har betonat strukturer framför Historical actors are central to the history of knowledge as they are to all historical scholarship. Every country, every era has its biographies of eminent scientists, intellectuals, and educational reformers. Yet the theoretical currents that have left their mark on the historical and sociological study of knowledge since the 1960s have emphasized structures over actors, collectives over individ
BACKGROUND: Plasma biomarkers for Alzheimer's disease (AD) have broad potential as screening tools in primary care and disease-modifying trials. Detecting elevated amyloid-β (Aβ) pathology to support trial recruitment or initiating Aβ-targeting treatments would be of critical value. In this study, we aimed to examine the robustness of plasma biomarkers to detect elevated Aβ pathology at different
Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory distress syndrome (ARDS). Although their potential remains undisputed in pre-clinical models, this has yet to be translated to the clinic. In this review, we focused on the role of microRNAs contained in MSC-derived EVs, the E
Natural selection generally favours phenotypic variability in camouflaged organisms, whereas aposematic organisms are expected to evolve a more uniform warning coloration. However, no comprehensive analysis of the phenotypic consequences of predator selection in aposematic and cryptic species exists. Using state-of-the-art image analysis, we examine 2800 wing images of 82 moth species accessed via
Transport electrification in Sweden is moving at a fast pace. Grid impact studies from EVs predominantly consider low-voltage grids. However, as the share of electric cars is rapidly increasing, potential grid impact at higher voltage levels needs to be considered. This paper presents a probabilistic approach to generate aggregated charging profiles for home charging at a sub-transmission grid lev
This study evaluates the performance of five satellite precipitation products (GPM IMERG, TRMM 3B42, ERA5, PERSIANN, and CHIRPS) compared to monthly observations from two weather stations (Laayoune and Essmara) over 2001–2017 using statistical metrics including correlation coefficient (CC) and mean square error (MSE). The results reveal notable differences between products. On a monthly timescale,
RNA sequencing (RNAseq) methodology has experienced a burst of technological developments in the last decade, which has opened up opportunities for studying the mechanisms of adaptation to environmental factors at both the organismal and cellular level. Selecting the most suitable experimental approach for specific research questions and model systems can, however, be a challenge and researchers i
This article presents a study of the female amateur Aurora von Qvanten (1818–1907), and her portrait of the famous Swedish singer, Jenny Lind (1829–1887), seen in relation to the contemporary array of portraits of Lind. Von Qvanten's work in the area of portraiture is virtually unknown, as is the case with that of most women artists of her time. Source material about von Qvanten is scarce, and her
An academic journal is a special place – even more so an online journal. On the one hand, it is surely one of the main stages of professional qualification, presentation and academic discourse, though regulated through its gatekeeping structures of peer review, official invitation, of academic critique and corrections: it represents an open and accessible, yet not unregulated public space in the b
An academic journal is a special place – even more so an online journal. On the one hand, it is surely one of the main stages of professional qualification, presentation and academic discourse, though regulated through its gatekeeping structures of peer review, official invitation, of academic critique and corrections: it represents an open and accessible, yet not unregulated public space in the b
Using an automatic computerized perimeter developed by Heijl & Krakau (1975b) three different perimetric test logics, one simple (I) and two more complicated and time-consuming (II & III) were investigated in practical experiments on healthy normal test subjects and patients and in computer simulated tests. The patients either had a verified diagnosis of glaucoma or glaucoma was suspected.
Hydroxy carboxylate viologen oxidoreductase (HVOR) contained in Proteus vulgaris cells was used in the reduction of chloropyruvic acid to D-(S)-chlorolactic acid. A synthetic electron mediator 1,1'-carbamoylmethylviologen (CAV) was used to transfer electrons to HVOR. Three different methods for regenerating the mediator were evaluated: (1) electrochemically driven reduction; (2) reduction driven
