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Purpose: The purpose of this paper is to explore how global operations of manufacturing companies influence the choice of product architecture decisions, ranging from integral to modular product designs. Design/methodology/approach: The authors perform a multiple-case study of three global manufacturing companies with integral and modular product architectures. Findings: The authors find that the
Path loss models are the most fundamental part of wireless propagation channel models. Path loss is typically modelled as a (single-slope or multi-slope) power-law dependency on distance plus a log-normally distributed shadowing attenuation. Determination of the parameters of this model is usually done by fitting the model to results from measurements or ray tracing. The authors show that the typi
Neurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public health challenge. As these diseases are difficult to diagnose clinically, biomarkers of underlying pathophysiology are playing an ever-increasing role in research, clinical trials, and in the clinical work-up of patients. Though cerebrospinal fluid (CSF) and positron emission tomography (PET)-based measures ar
Quantum refinement has repeatedly been shown to be a powerful approach to interpret and improve macromolecular crystal structures, allowing for the discrimination between different interpretations of the structure, regarding the protonation states or the nature of bound ligands, for example. In this method, the empirical restraints, used to supplement the crystallographic raw data in standard crys
In this paper, we describe Docforia, a multilayer document model and application programming interface (API) to store formatting, lexical, syntactic, and semantic annotations on Wikipedia and other kinds of text and visualize them. While Wikipedia has become a major NLP resource, its scale and heterogeneity makes it relatively difficult to do experimentations on the whole corpus. These experimenta
The European Spallation Source, currently under construction in Lund, Sweden, will be the world's most powerful neutron source. It is driven by a proton linac with a current of 62.5 mA, 2.86 ms long pulses at 14 Hz. The final section of its normal-conducting front-end consists of a 39 m long drift tube linac (DTL) divided into five tanks, designed to accelerate the proton beam from 3.6 MeV to 90 M
The glycyl-tRNA synthetase from Thermus thermophilus is a dimer of molecular mass 115 kDa, which has been crystallised using the vapour diffusion method from 5 to 7% polyethylene glycol 6000, 0.8 to 1.4 M NaCl at protein concentrations of 2 to 8 mg/ml. Nucleation is carried out at 4°C and crystals are subsequently transferred to 15°C to maximise growth. Crystals are truncated rhombohedra measuring
Purpose of Review: This article reviews controversial questions within the field of lung transplantation, with a focus on data generated within the last 3 years. We aim to summarize differing opinions on a selection of topics, including bridge-to-transplantation, intraoperative machine circulatory support, bronchial anastomosis, size mismatch, delayed chest closure, and ex vivo lung perfusion.Rece
Homogenous charge compression ignition engines have been studied as an alternative to the conventional diesel combustion to attain high efficiency with ultra-low NOx and soot emissions for a wide variety of fuels. However, its usage in real applications has been restricted due to the difficulties regarding combustion control and operating range extension. The modification of the fuel characteristi
While Bayesian Optimization (BO) is a very popular method for optimizing expensive black-box functions, it fails to leverage the experience of domain experts. This causes BO to waste function evaluations on bad design choices (e.g., machine learning hyperparameters) that the expert already knows to work poorly. To address this issue, we introduce Bayesian Optimization with a Prior for the Optimum
Ni-based composite coatings containing varied contents of tungsten carbides on low carbon steel were fabricated. Effects of sintering temperature and tungsten carbides contents on the surface, interface, microstructure and wear resistance of the coatings were investigated using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, Vickers microhardness tester, bulk
Experimentally determined vitamin degradation kinetic parameters are vital input for process optimization, e.g., of nutrient rich beverages such as milk and fruit juices. The standard method of obtaining these parameters is to subject a test-tube of the nutrient (in its food matrix) to a water bath at elevated temperatures and measure remaining concentration as a function of time. It is well known
Purpose: The purpose of this paper is to systematically review extant studies on what makes a country fully, partially or not adopt international financial reporting standards (IFRS) and categorize these factors into meaningful categories. In so doing, this study facilitates policy-making for accounting and economic standard setters and also points out conflicting viewpoints in the current literat
With the increasing requirements of compressed gas energy storage systems for compressors and expanders, sliding vane rotary compressors are worth trying. To study the influence of different configurations of discharge ports on the performance of compressors, numerical simulations are conducted on the innovative sliding vane compressors with a rotating cylinder. The reliable Renormalization Group
5-Azacitidine (AZA) therapy is used in high-risk myelodysplastic syndrome (MDS) patients who often show abnormalities in their immunophenotype. We explored the potential impact of AZA on these immunophenotypic abnormalities in serial bone marrow studies performed in 81 patients from five centers. We compared the immunophenotypic features before and after therapy with AZA, established definitions c
Globally, transportation and manufacturing emit large amount of greenhouse gases that needs to be lowered for reaching agreed upon clim ate goals. In this context evidence of mitigation activities among eighty-five companies and their forty-five parent companies in these two polluting sectors were traced focusing on a country that has committed itself to leading the implementation of ambitious cli
