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The purpose of this article is to argue for a position holding that epigenetic responsibility primarily should be a political and not an individual responsibility. Epigenetic is a rapidly growing research field studying regulations of gene expression that do not change the DNA sequence. Knowledge about these mechanisms is still uncertain in many respects, but main presumptions are that they are tr
In 2007, a new wave of local reforms involving choice for the population and privatisation of providers was initiated in Swedish primary care. Important objectives behind reforms were to strengthen the role of primary care and to improve performance in terms of access and responsiveness. The purpose of this article was to compare the characteristics of the new models and to discuss changes in fina
Water related problems are characterized by complexities, uncertainties, and conflicting interests and there is no single “optimal” way to approach these “wicked” problems. Model-assisted participatory processes have been suggested as one way to meet these challenges. However, the use of models as ascenario tools for local planning of mitigation and adaptation strategies addressing environmental c
Purpose The recruitment of participants to randomized controlled trials (RCTs) in palliative cancer care by health care professionals is often unsuccessful, which could result in failure to achieve study power. The purpose of this paper is to describe how health care professionals experienced recruiting patients and family caregivers to an RCT in palliative cancer care. Methods The study had a qua
We intended to perform optical and structural measurements on larval zebrafish eyes at 5 days post fertilization, that is, the earliest age at which zebrafish show visually guided behavior. However, excised larval crystalline lenses deteriorated quickly if immersed in a medium that gives good results with adult lenses from a variety of fish species. We suspected that the larvae have body fluids of
In this work, a three-dimensional, non-isothermal, steady-state model for high temperature proton exchange membrane fuel cells with phosphoric acid polybenzimidazole membrane has been developed using computational fluid dynamics. The importance of the gas flow field design on the transport characteristics and cell performance is revealed by solving the mass, momentum, species, energy, and charge c
In animal ethics animal capacity to suffer and experience is a selfevident point of departure when elaborating theories for respecting animals. Less often the practical consequences of "respecting an animal" is discussed in these theories, still they want to influence our behavior towards the animals. So, in order to know what is respectful, we need to connect scientific knowledge about an animal
Acquired aplastic anemia (AA) is considered to be an autoimmune mediated disease whereas in inherited bone marrow failure syndromes the genetic abnormalities account for the bone marrow dysfunction. The only curative treatment for inherited AA is hematopoietic stem cell transplantation (HSCT). Successful treatment for acquired AA has traditionally been considered with HSCT, whereas single agent th
Abstract in Spanish Los efectos clínicos y económicos de cada una de 3 alternatives en la profilaxis tromboembólica (no profilaxis, profilaxis general con heparina de baja dosis, y tratamiento selectivo) fueron valorados en 3 tipos de cirugía: cirugía general (abdominal), el subgrupo de cirugía general para colelitiasis, y cirugía electiva de cadera. Los costos de las complicaciones tromboembólicaThe clinical and economic effects of each of 3 alternatives—no prophylaxis, general prophylaxis, and selective treatment—have been assessed in conjunction with 3 types of surgery—general surgery, the subset surgery for cholelithiasis, and elective hip surgery. The costs of thromboembolic and hemorrhagic complications have been calculated from the figures for 28 patients hospitalized at the Departm
Software inspections are an efficient method to detect faults in software artefacts. In order to estimate the fault content remaining after inspections, a method called capture-recapture has been introduced. Most research published in fault content estimations for software inspections has focused upon point estimations. However, confidence intervals provide more information of the estimation resul
Emotional reactions are a vital part of the therapeutic relationship. The Feeling Word Checklist-24 (FWC-24) is an instrument asking the clinician (or the patient) to report to what degree he or she has experienced various feelings during a therapeutic interaction. The aim of this study was to assess the factor structure of the clinician-rated FWC-24 when taking dependencies in the data into accou
Context: The details of fecundity, such as its distribution and timing, can have important consequences for forest dynamics. Aims: We detail two aspects of the reproductive ecology of an exotic population of Pinus nigra in New Zealand. We compare our findings with those reported for P. nigra in southern France and Britain. Methods: We describe variation in fecundity, both within the population and
The focus of this paper is to explore better strategies for optimising bone strength and reducing risk of fracture, while at the same time decreasing risk of cardiovascular disease. The majority of Americans do not consume the current recommended dietary allowance for calcium, and the lifetime risk of osteoporosis is about 50%. However, traditional mononutrient calcium supplements may not be ideal
This study explored the ability of blind and sighted listeners to detect reflections, "echoes", of burst trains or continuous noise. Echo detection was compared by presenting 5 ms bursts, rates from 1 to 64 bursts, with a continuous white noise, all during 500 ms. Sounds were recorded in an ordinary room through an artificial binaural head, the loudspeaker 1 m behind it. The reflecting object was
Risks include the factors that might adversely affect project outcomes. Risk analysis includes the processes concerned with identifying, analyzing and developing security strategy and plans for the factors. Although currently there are known methodologies such as (CCTA Risk Analysis and Management Method (CRAMM) or Consultative, Objective and Bi-functional Risk Analysis(COBRA) and so on) for Risk
We study a design framework for robust, independently verifiable, and workload-balanced distributed algorithms working on a common input. The framework builds on recent noninteractive Merlin--Arthur proofs of batch evaluation of Williams~[31st IEEE Colloquium on Computational Complexity (CCC'16, May 29-June 1, 2016, Tokyo), to appear] with the basic observation that Merlin's magic is not needed fo
Species diversity promotes the delivery of multiple ecosystem functions (multifunctionality). However, the relative functional importance of rare and common species in driving the biodiversity-multifunctionality relationship remains unknown. We studied the relationship between the diversity of rare and common species (according to their local abundances and across nine different trophic groups), a
Various microchannel heat sinks are widely used to cool electronic chips, but they are often designed to be single-layer channels. To a certain extent, single-layered microchannel heat sinks can solve the problem of high heat flux. However, due to the limitation of pumping power, only a small coolant flow rate can be adopted; and the temperature of the heated plate is non-uniform. In this paper, t
