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Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic. Currently, there is only one modeling framework which can be applied to predict the progression of knee osteoarthritis but it only considers degenerative changes in the collagen fibril network. Here, we have developed the framework further by considering all of the major tissue changes (proteoglycan con
We consider the “minor” and “homeomorphic” analogues of the maximum clique problem, i.e., the problems of determining the largest h such that the input graph (on n vertices) has a minor isomorphic to Kh or a subgraph homeomorphic to Kh, respectively, as well as the problem of finding the corresponding subgraphs. We term them as the maximum clique minor problem and the maximum homeomorphic clique p
Polycythemia vera (PV) is a clonal stem cell disorder characterized by erythrocytosis and associated with burdensome symptoms, reduced quality of life, risk of thrombohemorrhagic complications, and risk of transformation to myelofibrosis and acute myeloid leukemia. The discovery of the JAK2 V617 mutation marked a significant milestone in understanding the pathophysiology of the disease and subsequ
An ultrahigh-pressure supercritical fluid extraction method was optimized and applied to extract seed oil lipids from two moringa species, namely Moringa oleifera (MO) and Moringa peregrina (MP). A full-factorial design was used to investigate the direct and interaction influence of pressure and temperature in the range of 40 to 80 MPa and
Ex-situ Raman spectroscopy is a well-established method for the structural characterization of soot but necessitates a sampling step before analysis is made. This work studied the potential to perform Raman spectroscopic measurements of soot directly in the combustion exhaust gases, i.e., online Raman measurements. Two types of soot were produced from a Mini-CAST soot generator, one immature with
Amyloid-β (Aβ) positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) biomarkers are now established tools in the diagnostic workup of patients with Alzheimer's disease (AD), and their use is anticipated to increase with the introduction of new disease-modifying therapies. Although these biomarkers are comparable alternatives in research settings to determine Aβ status, biomarker
The Miaolingian is the new formal name for Cambrian Series 3 (≈ “Middle” Cambrian). The Global Stratotype Section and Point (GSSP) is defined in the Kaili Formation, Guizhou province, China, and is correlated by the First appearance Datum (FAD) of the trilobite Oryctocephalus indicus. However, this fossil has not been recorded from Baltoscandia. Here acritarchs may be used for identifying the base
The majority of studies on mental health in deaf and hard-of-hearing (DHH) children report a higher level of mental health problems. Inconsistencies in reports of prevalence of mental health problems have been found to be related to a number of factors such as language skills, cognitive ability, heterogeneous samples as well as validity problems caused by using written measures designed for typica
The failure of key EU Member States to respect the provi- sions of the Stability and Growth Pact (SGP) a few years after its inception triggered a heated debate on how to reform the frame- work of fiscal policy coordination in the Economic and Monetary Union (EMU). This paper analyzes 101 reform proposals pre- sented by professional academic and non-academic economists prior to March 2005, when th
This article presents two case studies, which are the result of the application of a gendered interpretative tool to the collections at the Victoria & Albert Museum (London) and the Vasa Museum (Stockholm). Objects and their gendered narratives within the museums’ collections were researched across their lifecycle, from commission and manufacture to consumption and display in a museum setting.
In this study, we examined the evolutionary outcome of and interplay between historic isolation and current selection pressures on traits more or less closely connected to fitness in the Pearly Heath butterfly (Coenonympha arcania) across its range in Europe. We hypothesized that a trait mean is more related to historic events if it has low connection to fitness, while a trait more closely connect
The increased survival in malignant cutaneous melanoma (melanoma) is probably due to early diagnosis combined with improved treatment most recently. National health campaigns and screening programs for melanoma detection were started in Sweden several decades ago. We want to assess the influence of tumor characteristics, based on the TNM classification, and of second primary cancers on overall sur
Placebo comparisons are increasingly being considered for randomised trials assessing the efficacy of surgical interventions. The aim of this Review is to provide a summary of knowledge on placebo controls in surgical trials. A placebo control is a complex type of comparison group in the surgical setting and, although powerful, presents many challenges. This Review outlines what a placebo control
Vehicle-to-vehicle (V2V) wireless communications can improve traffic safety at road intersections and enable congestion avoidance. However, detailed knowledge about the wireless propagation channel is needed for the development and realistic assessment of V2V communication systems. We present a novel geometry-based stochastic MIMO channel model with support for frequencies in the band of 5.2-6.2 G
Intrinsically disordered proteins (IDPs) adopt heterogeneous conformational ensembles in solution. The properties of the conformational ensemble are dependent upon the solution conditions, including the presence of ions, temperature, and crowding, and often directly impact biological function. Many in vitro investigations focus on the properties of IDPs under dilute conditions, rather than the cro
The performance of a new type of X-band Weather Radar (WR) for Sweden during a pilot run is studied. Compared to the conventional C-band WRs, the X-band WR covers a smaller area but with a higher spatiotemporal resolution, making it suitable for urban hydrological applications. Rainfall estimations from different elevation angles of the radar (levels) are compared at one-minute and single-event ti
Writing as dusk fell on the mid-Republic, Ennius (238–169 BCE) purportedly remarked, ‘Kings throughout their kingship are in quest of statues and sepulchres; they build up a name and strain with all their might and main’. A poet whose verse mediated between the Greek and Roman worlds, he knew the weight of his words, and they usefully highlight the political presence of a tomb. Not that this is un
Two-dimensional gel-electrophoresis in combination with mass spectrometry is a powerful approach to compare protein expression in brain tissues. Using this proteomic approach, and based on the hypothesis that schizophrenia involves hypoglutamergic brain function, alterations in protein levels in the thalamus of rats treated with the N-methyl-D-aspartate (NMDA) receptor antagonist [+]-5-methyl-10,1
PurposeThis paper presents an integrated view of the literature published on all aspects and facets of competence in supply chain management (SCM) and furthermore provides a framework for classifying and analyzing literature to facilitate further study, practice, and research.Design/methodology/approachA systematic literature review identified 98 peer-reviewed scientific journal publications on th
BACKGROUND: Neuromuscular diseases (NMD) can affect the ability to be employed and to work, but there is limited knowledge of individuals' own perspectives of factors that are important for their vocational situation. OBJECTIVE: To explore the vocational situation among people with NMD that are employed, and to describe their experiences of how their disability, personal and environmental factors
