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Acute lymphoblastic leukemia (ALL), the most common malignant disorder in childhood, is typically associated with numerical chromosomal aberrations, fusion genes or small focal deletions, thought to represent important pathogenetic events in the development of the leukemia. Mutations, such as single nucleotide changes, have also been reported in childhood ALL, but these have only been studied by s
Objective: Inflammation is associated with higher incidence of perinatal brain injury. To better understand the mechanisms behind these injuries, we have studied the immune cell trafficking into the central nervous system (CNS) through the choroid plexus (CP) in the newborn. Meth-ods: Inflammation was induced in newborn mice using two different toll-like receptor ago-nists: PAM3CSK4 (PAM) and lipo
This paper investigates the time-discrete multitapers that give a mean square error optimal Wigner spectrum estimate for a class of locally stationary processes (LSPs). The accuracy in the estimation of the time-variable Wigner spectrum of the LSP is evaluated and compared with other frequently used methods. The optimal multitapers are also approximated by Hermite functions, which is computational
In recent years the treatment of cancer with radioactive drugs, here termed molecular radiotherapy (MRT), has emerged to take a place alongside other treatment modalities, particularly non-radioactive drugs (NRDs) and external beam radiotherapy (EBRT). A purpose-built tool was developed within the Python programming environment to review the evolution of clinical trials performed in the first quar
A numerical study was carried out to examine the development of duct flows being affected by combined buoyancy force-driven secondary flow and mass transfer. The developing flow and heat transfer have been simulated numerically for a horizontal fuel cell duct with rectangular and trapezoidal cross section. Constant heat flux and mass transfer rate are prescribed on the bottom wall, while thermal i
Doctoral education has been shaped by a continuous interaction between the research community and representatives of the governmental authorities. In Sweden, doctorates were organised into structured educational programmes in 1969. In this study, the development of doctoral education in Medical Radiation Physics at Lund University, Sweden, was analysed over approximately 50 years, in terms of quan
Research topic/aim:The digitalization of education is a prioritized field for governments and policymakers all over the world, not least in the Nordic countries. The educational sector is expected to play an important role in the digitalization of society and in fostering digital citizens, and to harness the potential of technology for improving its own practices (ITU, UNESCO & Unicef, 2020).
Natural killer cells are part of the immune system and one of their main functions is to dispose of cancer cells and virus-infected cells. In order to avoid detection by T cells, cancer cells can decrease the expression of MHC I proteins which instead can make them a target for NK cells, making NK cells a suitable for use in therapy. This study sought to investigate the cytotoxic ability of NK cel
In this work aMatlab model of a simplified LTE system has been implemented. The PUSCH and PDSCH signal chains has been used for reception and transmission of data and DM-RS symbols are used as pilots. Moreover, the model supports communication and interference between multiple users and base station antennas. The wireless channels are modeled as multi-path Rayleigh fading and are continuous in tim
Aerosol-cloud interactions constitute a major uncertainty in future climate predictions. This study combines 10 years of ground-based aerosol particle measurements from two Nordic background stations (Vavihill and Hyytiala) with MODIS (Moderate Resolution Imaging Spectroradiometer) satellite data of convective clouds. The merged data are used to examine how aerosols affect cloud droplet sizes and
Detailed quantitative analysis of the vulnerability of different hippocampal and striatal neurons to global forebrain ischemia has not previously been performed. Here we have studied the survival of immunocytochemically identified neurons using an unbiased stereological method in rats subjected to global forebrain ischemia for 30 min and sacrificed 48 h, 1 week or 4 weeks thereafter. Within the hi
Purpose: To compare the ability of Fast Swedish interactive threshold algorithm (SITA) short-wavelength automated perimetry (SWAP), lengthier full-threshold SWAP, and standard automated perimetry (SAP) using the SITA Fast program to detect early glaucomatous visual field loss. Design: Cross-sectional prospective study of perimetric diagnostic sensitivity as defined by reference limits determined i
