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Building the European Spallation Source (ESS), the most powerful neutron source in the world, requires significant technological advances at most fronts of instrument component design. Detectors are not an exception. The existing implementations at current neutron scattering facilities are at their performance limits and sometimes barely cover the scientific needs. At full operation the ESS will y
This chapter examines the long-run relationship between public opinion, party politics, and the welfare state. It argues that when large parties receive a clear signal concerning the median voter’s position on the welfare state, vote-seeking motivations dominate and the large parties in the party system converge on the position of the median voter. When the position of the median voter is more dif
This study presents a new method for estimation and imaging of the area at risk (AaR) in myocardial infarction (MI). The values of the ST-segment deviations of 12-lead ECG signal were used as input parameters. Based on DECARTO model, the spherical surface was chosen as a reference surface to approximate the ventricular wall. On this surface, the spatial ST vector was projected. The center of AaR w
In this study, bread was baked with and without the addition of α-amylase. Starch was extracted from the baked bread and its molecular properties were characterized using 1H NMR and asymmetric flow field-flow fractionation (AF4) connected to multi-angle light scattering (MALS) and other detectors. The approach allows determination of molar mass, root- mean-square radius and apparent density as wel
Though many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression and analysis of cis-elements in gene promoters to decipher the general organizat
This research discusses the importance of a photograph of an accused war criminal, Abdul Kader Molla, during the period immediately before the emergence of the Shahbag movement in Bangladesh. The image captures Kader Molla flashing a V sign, and it was taken in the moments after he had been sentenced to life imprisonment by the International Crimes Tribunal in Bangladesh in 2013. After Kader Molla
A major obstacle in ex vivo gene transfer has been the loss of transgene expression soon after implantation of the grafted transduced cells. Recently, a lentiviral vector system has been developed which has proven to express high levels of transgenes in vivo after direct injection into the tissue. In this study, we have investigated the use of such a vector for ex vivo gene transfer to the brain.
Sheet bulk metal forming processes are applied in order to produce tailored workpieces at high quality. Thereby, effort is made to optimise frictional and wear behaviour by designing the structures of the contact surfaces. Numerical process analysis can evoke a deeper under-standing of the functionality of such surface structures. In this contribution, a finite element framework for the simulation
The effects of trifluoperazine (TFP) on fast and slow axonal transport (AXT) of labeled proteins were examined in the rabbit vagus nerve. Cuffs soaked in a 10 mM, but not 0.1 mM or 1 mM, concentration of TFP applied locally around the vagus nerve in vivo blocked both fast and slow AXT, as measured by the accumulation of 3H‐labeled proteins. In vitro, fast AXT was affected by 0.1 mM TFP. The TFP cu
We theoretically investigate nonlinear ballistic thermoelectric transport in a superlattice-structured nanowire. By a special choice of nonuniform widths of the superlattice barriers - analogous to antireflection coating in optical systems - it is possible to achieve a transmission which comes close to a square profile as a function of energy. We calculate the low-temperature output power and powe
Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the r
Neutral particle oscillations have proven to be extremely valuable probes of fundamental physics. For instance, kaon oscillations provided us with our first insight into CP-violation, B oscillations form the most fertile ground for the continued study of CP-violation, and neutrino oscillations suggest the existence of a new, important energy scale well below the GUT scale. Neutrons oscillating int
