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This study investigates the toxic effect of E(2)nonenal (trans-2-nonenal, T2N) and its conjugate with horse muscle myoglobin (Mb) tested on murine cell line L929 and human cell line A549, as well as the genotoxic effect of these compounds assayed by measuring of micronuclei in human cells K562. It is an aldehyde, which is occurring as the substance responsible for an off flavour in aged beers, but
This dissertation focuses on the medieval nobility and its manors in the inland of Småland. The problems tackled in the dissertation may be divided into two major complexes. One concerns the emergence and growth of the Småland nobility in a long-term perspective, the second concerns the spatial conditions in which the nobles established their manors in the landscape. An important question concerns
The aim of this thesis was to develop and apply self-registered and observed measures of physical function in people with arthritis in the lower extremity. In Paper I, 181 subjects from the Swedish Knee Arthroplasty Register who were satisfied with their primary knee arthroplasty were studied. 44% of the medical records included reports of pain in the replaced knee at the same time as the patient
In the name of transparency and accountability, numbers and statistics have gained importance as indicators of quality, effectiveness and efficiency of welfare services such as social work. It has been argued that the requirements to formalise how and on what grounds decisions are made have undermined the professional autonomy and discretion of social workers. These requests have arguably also led
This study investigates the challenges and potential pathways for improved science communication, particularly in regards to research on the topic of smallholder food security and for science being generated by universities in sub-Saharan Africa. Questions asked in this study include those that aim to identify the academic substrate from which a university based in Africa must navigate. It also i
Denna kunskapssammanställning beskriver hur hälsoskadlig värme kan uppstå inomhus, hur den kan identifieras och vilka åtgärder som kan vidtas med fokus på fastighetsägarens ansvar. Sammanställningen är begränsad till befintliga byggnader i Sverige och inkluderar skolor, äldreboenden, lägenheter, förskolor och kontor som är icke-industriella (utan industriella processer som producerar värme). Den pThis literature review describes how heat stress can develop indoors, how it can be identified, and what actions can be taken, with a focus on property owner’s responsibilities. The review is limited to existing buildings in Sweden and includes schools, retirement homes, apartments, preschools, and non-industrial offices (those without industrial processes that produce heat). The expected climate
Dermal chemical exposure is common in many professions. The filaggrin protein is important for the skin barrier and variations in the filaggrin gene (FLG) may influence the uptake of chemicals via the skin, and consequently, the degree of systemic effects. The aim of this study was to investigate, in chimney sweeps with occupational exposure to polycyclic aromatic hydrocarbons (PAH) from soot, the
Intellectual property rights (IPRs) represent a key concern for researchers and industry in basically all (high-tech) sectors. IPRs regularly figure prominently in scientific journals and at scientific conferences and lead to dedicated workshops to increase the awareness and “IPR savviness” of scientists. In 2015, Biotechnology Journal published a report from an expert meeting on “Synthetic Biolog
Dynamic global vegetation models are a common tool to assess the effect of climate and land use change on vegetation. Though most applications of dynamic global vegetation models use plant functional types, some also simulate species occurrences. While the current development aims to include more processes, e.g. the nitrogen cycle, the models still typically assume an ample seed supply allowing al
This dissertation is about the Swedish filmmaker, painter and composer Peter Kylberg (1938). Kylberg’s nine films produced between 1959 and 1996 serves as a historical delimitation. A purpose of the study is to critically review the existing historical writing surrounding Swedish film culture and film politics, during the timespan in focus. The approach of the dissertation is chronological and pre
In many ways can Thomas More’s vision in his classic Utopia from 1516 lend itself to describe Sweden as no longer a great power in war, as had been the case in the 17th and early 18th century, but an egalitarian nation and also in other aspects a peaceful, humanitarian example to follow. The ideal that More envisioned is to be understood as an unattainable and therefore unrealistic dream; his idea
Människans vilja att förstå universums mest fundamentala byggstenar och dess naturlagar är den drivkraft som ligger till grund för elementarpartikelfysiken. Den teoretiska forskningen inom detta område vägleds idag till stor del av data från LHC-experimentet utanför Genève (LHC förkortar `Large Hadron Collider', dvs.~den Stora Hadronacceleratorn). Vid LHC accelereras protoner till extremt höga hasThe four articles contained in this thesis all concern aspects of model building beyond the Standard Model (BSM). While Paper I mainly serves as a ``tool paper'' in which the results can be used to simplify certain calculations of one-loop effects from new heavy particles, Paper II--IV all deal with consequences of family symmetries in several BSM scenarios. Paper I. We derive expressions for any
As a result of climate change warmer temperatures are projected through the 21st century and are already increasing above modelled predictions. Apart from increases in the mean, warm/hot temperature extremes are expected to become more prevalent in the future, along with an increase in the frequency of droughts. It is crucial to better understand the response of terrestrial ecosystems to such temp
Introduction: Middle Eastern immigrants exhibit high levels of physical inactivity and are at an increased risk for Type 2 diabetes. The primary aim of this study was to examine the changes in objectively assessed physical activity levels following a culturally adapted lifestyle intervention program. The secondary aim was to examine the association between objectively assessed physical activity an
BACKGROUND: Disability either due to illness, aging, or both causes remains an essential contributor shaping European labor markets. Ability of modern day welfare states to compensate an impaired work ability and absenteeism arising from incapacity is very diverse. The aims of this study were to establish and explain intercountry differences among selected European OECD countries and to provide fo
Background: The ESPAC-3 trial showed that adjuvant gemcitabine is the standard of care based on similar survival to and less toxicity than adjuvant 5-fluorouracil/folinic acid in patients with resected pancreatic cancer. Other clinical trials have shown better survival and tumour response with gemcitabine and capecitabine than with gemcitabine alone in advanced or metastatic pancreatic cancer. We
Angiogenesis provides growing tumors a source of nutrients and oxygen, and a route for metastatic dissemination. In recent years anti-angiogenic therapies that primarily target the vascular endothelial growth factor (VEGF) signaling cascade have entered the clinic. However in practice, these have encountered unexpected mechanisms of resistance in many solid tumors, highlighting the need for furthe
