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In the brain, focal ischemia results in a local region of cell death and disruption of both local and remote functional neuronal networks. Tissue reorganization following stroke can be limited by factors such as extracellular matrix (ECM) molecules that prevent neuronal growth and synaptic plasticity. The brain's ECM plays a crucial role in network formation, development, and regeneration of the c
Popular Abstract in Swedish Vårt immunsystem har utvecklats för att skydda våra vävnader och organ vid infektioner, cancerväxt och andra skador. Immunsystemet utgörs av en mängd olika celltyper som på olika sätt specifikt, främst genom uttryck av receptorer på cellytan, reagerar på främmande strukturer, från t ex patogener eller tumör celler eller andra substanser som signalerar stress eller fara.This thesis is based on three original papers with the overall aim to study the mechanisms of induction and function of Foxp3+CD4+CD25+ regulatory T cells. Regulatory T cells induce down-modulation of costimulatory molecules CD80 and CD86 on dendritic cells in vitro. In the first study we further show that the extent of down-modulation is functionally significant since regulatory T cell condition
Popular Abstract in Swedish En av dagens största utmaningar är de stadigt ökande utsläppen av förorenande avgaser och drivhusgaser. Den största delen av dessa föroreningar kommer från förbränningsanläggningar och fordon. För att kunna minska utsläppen måste man förstå förbränningsprocesserna, och hur man kan kontrollera förbränningen. Utmaningen är att förbränningprocesser är mycket komplexa. Det To deal with complex physical and chemical processes in reactive systems, such as combustion processes, it is necessary to find methods that simplify modelling in such a way that it becomes both more comprehensible and practically useful. In the work reported here a method for automatically reducing chemical reaction mechanisms has been developed for use in computer simulations of various combusti
Ett antal superkontinenter har existerat under jordens 4.6 Ga ( miljarder år gamla ) historia. Utav dessa är superkontinenten Pangea, som betyder ”allt land”, den senaste och mest väldefinierade. Bildning och uppsprickning av superkontinenter drivs av plattektoniska processer som i sin tur beror på strömningar ( konvektion ) i jordens mantel. Förutom dessa processer så anses numera mantelplymer haEarth history is punctuated by a series of events of supercontinent amalgamation and break-up. Fragments of old continents display rifted margins and orogenic sutures that testify their involvement in supercontinent cycles. Periods of break-up are associated with widespread magmatism due to extensional thinning and rifting of the lithosphere and in some instances the arrival of mantle plumes. Mant
Popular Abstract in Swedish Med utvecklingen av lasern tillkom ett diagnostiserningsverktyg för forskning inom medicin, biologi, fysik, kemi mm. En laser är i princip en ljuskälla som skickar ut ljus med synnerligen välbestämd färg och riktning. Ljus som har en viss färg kan påverka vissa molekyler och atomer. Under vissa förutsättningar svarar dessa ämnen genom att i sin tur skicka ut ljus i en a
The aim of this work was to develop a model suited for detailed studies of aerosol dynamics, gas and particle phase chemistry within urban plumes, from local scale (1x1 km(2)) to regional scale. This article describes and evaluates the trajectory model for Aerosol Dynamics, gas and particle phase CHEMistry and radiative transfer (AD-CHEM). The model treats both vertical and horizontal dispersion p
Abstract Global change and GHG emission modelling are dependent on accurate wetness estimations for predictions of e.g. methane emissions. This study aims to quantify how the slope, drainage area and the TWI vary with the resolution of DEMs for a flat peatland area. Six DEMs with spatial resolutions from 0.5 to 90 m were interpolated with four different search radiuses. The relationship between ac
Growing evidence for declines in wild bees calls for the development and implementation of effective mitigation measures. Enhancing floral resources is a widely accepted measure for promoting bees in agricultural landscapes, but effectiveness varies considerably between landscapes and regions. We hypothesize that this variation is mainly driven by a combination of the direct effects of measures on
Sedan tillkomsten av den nuvarande rättegångsbalken på 1940-talet har utgångspunkten i svensk rätt varit att bevisprövningen ska vara fri och inte styrd av legala normer. Detta hindrade emellertid inte lagstiftaren från att i förarbetena ställa upp krav på att bevisprövningen skulle vara objektiv och analytisk. Som en följd därav utvecklades ett antal bevisprövningsmetoder i den juridiska doktrine
Emissions of air pollutants from shipping in Europe result in about 50 000 premature deaths every year. Soot particles, also called black carbon, are particularly hazardous to human health when inhaled. The adverse health effects are especially a danger in coastal areas, but the particles can travel further away with the wind. These soot particles also have an effect on the climate. Fresh soot par
The accession to the European Union was based on the financial gains that could be made on the single market. When acceding the Union the Member States gave up parts of their state sovereignty. This statement is not unproblematic. My thesis touches on the posting of workers. Since the adoption of the new Enforcement Directive on the Posting of Workers Directive, two reports on the Swedish impleme
I Sverige finns ett antal webbplatser som samlar in offentliga handlingar och tillgängliggör dessa genom en söktjänst. Internetanvändare kan genom en sådan söktjänst, ofta efter erlagd betalning, till exempel se om någon förekommer i en fällande brottmålsdom. Webbplatserna är grundlagsskyddade genom utgivningsbevis. Möjligheten att ansöka om utgivningsbevis finns sedan 2003 genom en bestämmelse i
In this project particle production as a function of transverse momentum (\(p_{\rm T}\)) in proton-proton collisions at a center-of-mass energy (\(\sqrt{s}\)) of 7 TeV and 13 TeV has been studied. The transverse momentum is interesting to study since it reflects momentum created in the collision (before the collision, all momentum is in the beam - going in a longitudinal direction) and therefore g
Uganda faces various challenges related to compliance, including tax evasion, regulatory non- compliance, and violations of legal standards, laws, policies and regulations among others. These issues undermine the government's ability to collect revenue, provide public services, and maintain law and order. Enhancing compliance is not only a matter of enforcing penalties but also involves creati
Title: Adaptation of shipment consolidation and distribution network design to omni-channel retailing Authors: Johan Deniz, Martin Månsson Supervisor: Joakim Kembro, Department of Industrial Management and Logistics, Faculty of Engineering, Lund University Problem description: Global retailers tend to have complex distribution networks. A part of the complexity stems from trade-offs in deciding
BACKGROUND: Treatment of newly diagnosed advanced-stage ovarian cancer typically involves cytoreductive surgery and systemic chemotherapy. We conducted a trial to investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery would improve outcomes among patients who were receiving neoadjuvant chemotherapy for stage III epithelial ovarian ca
IMPORTANCE Moderate-grade adolescent idiopathic scoliosis (AIS) may be treated with full-time bracing. For patients who reject full-time bracing, the effects of alternative, conservative interventions are unknown. OBJECTIVE To determine whether self-mediated physical activity combined with either nighttime bracing (NB) or scoliosis-specific exercise (SSE) is superior to a control of physical activ
Heart failure (HF) is a leading cause of death and disability globally. HF represents the common end- stage of most heart conditions, during which the heart is unable to generate sufficient output of blood for the metabolic demands of the body and intracardiac pressures increase. Different heart diseases display specific molecular pathophysiologies, but common pathways are also present that drive
Background: SARS-CoV-2 mRNA vaccination has been associated with both side effects and a reduction in COVID-related complaints due to the decrease in COVID-19 incidence. We aimed to investigate if individuals who received three doses of SARS-CoV-2 mRNA vaccines had a lower incidence of (a) medical complaints and (b) COVID-19-related medical complaints, both as seen in primary care, when compared t
