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Drug Expenditure and New Drug Introductions : The Swedish Experience

This article measures the impact of the switch to new and more expensive drugs on the aggregate drug expenditure (both prescription and nonprescription) in Sweden during the period 1974 to 1991, and also on the disaggregated expenditure for 3 medical areas: asthma, hypertension and peptic ulcer disease. During the period studied, nominal drug expenditure increased 6-fold. The retail price index of

Flow pulsation plays an important role for high-pressure homogenization in laboratory-scale

Most experimental and numerical investigations of high-pressure homogenizers assume that the valve is fed with a constant flowrate. However, technical homogenizers use piston pumps with either 3 or 5 pistons (production- and pilot-scale machines) or a single piston (laboratory-scale machines). This results in flow pulsation. It is still unknown to what extent this influences valve hydrodynamics. M

A rate-dependent continuum model for rapid converting of paperboard

A rate-dependent continuum model for paperboard is developed within a framework for finite strains and finite deformations. A multiplicative split of the deformation gradient into an elastic and an inelastic part is assumed. For the in-plane modes of deformation, viscoelasticity is introduced via a thermodynamically consistent generalization of the Maxwell formulation. The elastic transition betwe

Where drills differ from evacuations : A case study on Canadian buildings

Planned egress drills are required by building codes around the world, and are commonly used to both train occupants and assess evacuation procedures. However, capturing the idea of a “successful” drill is often difficult. Data from both drills and unplanned evacuations are often incomplete and unreliable, which raises a key question: How well-matched are planned egress drills and unplanned evacua

Numerical study of flow inhomogeneity and heat transfer enhancement in structured packed beds

Packed beds are widely used in engineering applications due to their high specific surface area and good heat transfer characteristics. A grille-sphere composite packed bed is proposed previously and has been proved to have higher overall heat transfer coefficient than the simple cubic packing structure. In the present paper, the flow inhomogeneities in both the grille-sphere composite packed bed

Dehydrogenation mechanisms of liquid organic hydrogen carriers over Pt, Pd, Rh, and Ni surfaces : Cyclohexane as a model compound

In order to make a better understanding of dehydrogenation mechanisms of liquid organic hydrogen carriers, cyclohexane was selected as a model compound to carry out its decomposition studies over Pt(1 1 1), Pd(1 1 1), Rh(1 1 1), and Ni(1 1 1) surfaces via periodic density functional theory calculations. The adsorption geometries and adsorption energies of reaction intermediates were presented. Sim

Ethnographic discovery after fieldwork with troubled youth

The cultivation of ethnographic discovery is not only about being insightful in the field by paying attention to unexpected events and unforeseen social processes. We should also search for potentially surprising or disturbing findings after the fieldwork. This can provide additional ways to create an original and sustainable understanding of research material. In this chapter, we discuss a study

Solution of universal nonrelativistic nuclear DFT equations in the Cartesian deformed harmonic-oscillator basis. (IX) HFODD (v3.06h) : A new version of the program

We describe the new version (v3.06h) of the code HFODD that solves the universal nonrelativistic nuclear DFT Hartree-Fock or Hartree-Fock-Bogolyubov problem by using the Cartesian deformed harmonic-oscillator basis. In the new version, we implemented the following new features: (i) zero-range three- and four-body central terms, (ii) zero-range three-body gradient terms, (iii) zero-range tensor ter

Two Countermeasures Against Hardware Trojans Exploiting Non-Zero Aliasing Probability of BIST

The threat of hardware Trojans has been widely recognized by academia, industry, and government agencies. A Trojan can compromise security of a system in spite of cryptographic protection. The damage caused by a Trojan may not be limited to a business or reputation, but could have a severe impact on public safety, national economy, or national security. An extremely stealthy way of implementing ha

Time-resolved relaxation and fragmentation of polycyclic aromatic hydrocarbons investigated in the ultrafast XUV-IR regime

Polycyclic aromatic hydrocarbons (PAHs) play an important role in interstellar chemistry and are subject to high energy photons that can induce excitation, ionization, and fragmentation. Previous studies have demonstrated electronic relaxation of parent PAH monocations over 10–100 femtoseconds as a result of beyond-Born-Oppenheimer coupling between the electronic and nuclear dynamics. Here, we inv

Regional skillnad i incidensen av skador efter ledprotesoperation

Hip and knee arthroplasties are mostly successful procedures; however, patient injuries may occur and should be reported to Löf, the Swedish patient insurance. This study investigated the incidence of patient injuries after primary total hip and knee arthroplasty in the Swedish regions, differences in incidence depending on annual surgical volume, and types of approved injuries. Approved patient i

Abrupt termination of the 2019/20 influenza season following preventive measures against COVID-19 in Denmark, Norway and Sweden

BackgroundIn mid-March 2020, a range of public health and social measures (PHSM) against the then new coronavirus disease (COVID-19) were implemented in Denmark, Norway and Sweden.AimWe analysed the development of influenza cases during the implementation of PHSM against SARS-CoV-2 in the Scandinavian countries.MethodBased on the established national laboratory surveillance of influenza, we compar

LGBTQIA+ Organizations

Organizations advocating for the rights of LGBTQIA+ people are found all around the globe. These organizations champion the rights of lesbian, gay, bisexual, transgender, queer, intersex, asexual, aromantic, and agender individuals, with the plus-sign acknowledging those who are part of the community without fitting neatly into any of these specific categories. This entry details the early history