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Transcription factor (TF)-based reprogramming of somatic tissues holds great promise for regenerative medicine. Previously, we demonstrated that the TFs GATA2, GFI1B, and FOS convert mouse and human fibroblasts to hemogenic endothelial-like precursors that generate hematopoietic stem progenitor (HSPC)-like cells over time. This conversion is lacking in robustness both in yield and biological funct
Over Boreal regions, monoterpenes emitted from the forest are the main precursors for secondary organic aerosol (SOA) formation and the primary driver of the growth of new aerosol particles to climatically important cloud condensation nuclei (CCN). Autoxidation of monoterpenes leads to rapid formation of Highly Oxygenated organic Molecules (HOM). We have developed the first model with near-explici
1,9-Nonanedioic acid is one of the valuable building blocks for producing polyesters and polyamides. Thereby, whole-cell biosynthesis of 1,9-nonanedioic acid from oleic acid has been investigated. A recombinant Corynebacterium glutamicum, expressing the alcohol/aldehyde dehydrogenases (ChnDE) of Acinetobacter sp. NCIMB 9871, was constructed and used for the production of 1,9-nonanedioic acid from
Comparative proteome analysis was performed between RT4 (grade-1) and T24 (grade-3) bladder cancer cell lines, in an attempt to identify differentially expressed proteins during bladder cancer progression. Among those relatively abundant proteins, seven spots changed more than two-fold reproducibly and identified by peptide mass fingerprinting using mass spectrometry and database search. We found
Dion–Jacobson (DJ) type 2D perovskites with a single organic cation layer exhibit a narrower distance between two adjacent inorganic layers compared to the corresponding Ruddlesden–Popper perovskites, which facilitates interlayer charge transport. However, the internal crystal structures in 2D DJ perovskites remain elusive. Herein, in a p-xylylenediamine (PDMA)-based DJ perovskite bearing bifuncti
Food accessibility has been an important issue for as long as there has been human civilisation. Today, food, at least in the wealthier parts of the world, is accessible to most people. However, there are concerns regarding the market power of major retailers and the availability of affordable food among certain population groups. In this paper, I investigate how well accessibility, the ease with
The process of protein crystallization from aqueous protein solutions is still insufficiently understood. During macroscopic crystal formation, occurring often on time scales from a few hours to several days, protein dynamics evolves on the molecular level. Here, we present a proof of concept and a framework to observe this evolving diffusive dynamics on the pico- to nanosecond time scale, associa
Non-traditional examples can be very inspiring for students. This paper applies classical mechanics to different ways of skating in ice hockey. Skating blades glide easily along the ice in the direction of the blade. Horizontal forces on the skates are thus essentially perpendicular to the blade. Speed skaters glide long distances on each skate before pushing off for the next stride. A hockey play
Thinking with Performance: Research-Based Aesthetics in Times of Conflict and Crisis is an artistic research project in which I examine how to critically think with performance. My main thesis is that research-based performance uses research to respond to conflict and crisis and to create spaces for thinking where artist and audience can reflect on the represented material. As such the research-ba
This study investigated age-related changes in the human brain function using both traditional EEG analysis (power spectra) and the correlational dimension, a measure reflecting the complexity of EEG dynamics and, probably, the complexity of neurophysiologicaI processes generating the EEG. Assuming that the accumulation of individual experience is determined by the formation of functionally relate
Manipulation of specific binding and recycling of materials are two important aspects for practical applications of molecularly imprinted polymers. In this work, we developed a new approach to control the dynamic assembly of molecularly imprinted nanoparticles by surface functionalization. Molecularly imprinted polymer nanoparticles with a well-controlled core-shell structure were synthesized usin
