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During brain embryogenesis, transcription factors drive stem cells towards neuronal fate. Here we show that the transcription factor Pax6 increased in vitro generation of neurons from striatal but not cortical neural stem cells (NSCs), derived from 6 to 9 weeks old human fetuses, without affecting survival and proliferation. Overexpression of mouse Pax6 produced increased numbers of GABA+ and DARP
This study examines the effect of three regimens (organizations of activities) on the realism in dyad’s confidence judgments. The effect of letting the pair members first work alone when selecting an answer and/or when confidence rating the correctness of this answer was compared with working directly in pairs. No improvement in the realism of the dyads’ final confidence judgments was found as an
PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated embryonic blood vessels and reduced numbers of both pericytes and trophoblasts. T
Phosphoproteomics relies on methods for efficient purification and sequencing of phosphopeptides from highly complex biological systems, especially when using low amounts of starting material. Current methods for phosphopeptide enrichment, e.g., Immobilized Metal ion Affinity Chromatography and titanium dioxide chromatography provide varying degrees of selectivity and specificity for phosphopeptid
In January 2004, Per Hall et al in an article in British Medical Journal stated that children under the age of 18 months, who underwent CT of the brain, could get negative effects on cognitive abilities in adulthood. At the Department of Radiology, Lund University Hospital, 55 children under the age of 18 months underwent CT of the brain during 2004 compared to 70 children in 2003. MRI of the brai
The article describes a survey of the societal services in Sweden that are available after a spinal cord injury. These services are allocated to allow independence and financial compensation. I have investigated the kinds of services that are available. I have also interviewed 34 of a total incidence population of 48 people, to find out which services were applied for, and to describe the levels o
BACKGROUND: The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms. METHODS: Ten patients took part in lumbar punctures and psychiatric evaluations in conju
Obesity is a major global public health problem, and understanding its pathogenesis is critical for identifying a cure. In this study, a gene knockout strategy was used in post-neonatal mice to delete synoviolin (Syvn)1/Hrd1/Der3, an ER-resident E3 ubiquitin ligase with known roles in homeostasis maintenance. Syvn1 deficiency resulted in weight loss and lower accumulation of white adipose tissue i
A modified version of the point coordination function (PCF) in the IEEE 802.11 standard called Modified PCF has been introduced as an approach to improve channel utilization over the standard. It has been shown in our previous work that the utilization of the wireless channel can be significantly improved. In this paper, we investigate the performance of the Modified PCF when it is applied with a
Transformative change of energy systems towards distributed renewable technologies requires not only technological but also organisational innovation in order to engage broad segments of the private consumer group. Using the business model concept as an analytical tool, this comparative study investigates organisational configurations related to the deployment of customer-sited photovoltaic (PV) s
In the present contribution we review some recent work on scattering of electromagnetic waves from various geophysical targets, by means of P. C. Waterman's approach. As an introduction to the specific applications to be described, a general outline is given of the basic features of this approach, as applied to electromagnetic waves. The algebraic structure of the resulting equations for single an
This article deals with excited-state properties and spectroscopies which probe them. We argue that the orbitals obtained in local density theory form an excellent basis for discussing excited states and that the self-energy operator (or optical potential) associated with one-electron-type excited states is closely diagonal in such a basis. This diagonality often leads to considerable simplificati
A prevailing hypothesis is that neurogenesis is reduced in depression and that the common mechanism for antidepressant treatments is to increase it in adult hippocampus. Reduced neurogenesis has been shown in healthy rats exposed to stress, but it has not yet been demonstrated in depressed patients. Emerging studies now indicate that selective serotonin reuptake inhibitors can, exert behavioral ef
Antalet barn som flyr till Sverige har under de senaste åren ökat. Dessa barn har rätt till en välfungerande skolgång, men kan stå inför vissa utmaningar. Det här arbetets syfte var att undersöka vilka roller som aktualiseras hos skolpsykologer i arbetet med flyktingbarn, vad dessa roller hade för innehåll och vilka utmaningar som kan uppstå. Studiens resultat baserades på intervjuer med fyra skol
The development during the Crimea crisis as well as Russia´s escalating numbers and extent of exercises has put Swedish security policy on the agenda after being almost invisible for over a decade. This work aims to investigate on which fundament Swedish security policy rests and why Sweden choose to stand outside an alliance. The answers then also answers the main question; how to understand Swed
In this qualitative study the author examines the United Nations security council and its possibilities to reform, with help of George Tsebelis theory regarding veto players. The application of the veto player theory gives the ability to measure the policystability, the extent of ability to change policy, when adding more players to a political institution. The study is based on the United Nations
As a result of the official report on democracy (Demokratiutredningen), the Swedish government decided in 2002 to prescribe by law the right of initiation for common citizens in city councils (medborgerlig förslagsrätt). All citizens are therefore now entitled to submit a proposal which then will be dealt with by the city council as a motion. In this paper the handling of the citizen proposal is s
