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The threat of hardware Trojans has been widely recognized by academia, industry, and government agencies. A Trojan can compromise security of a system in spite of cryptographic protection. The damage caused by a Trojan may not be limited to a business or reputation, but could have a severe impact on public safety, national economy, or national security. An extremely stealthy way of implementing ha

Polycyclic aromatic hydrocarbons (PAHs) play an important role in interstellar chemistry and are subject to high energy photons that can induce excitation, ionization, and fragmentation. Previous studies have demonstrated electronic relaxation of parent PAH monocations over 10–100 femtoseconds as a result of beyond-Born-Oppenheimer coupling between the electronic and nuclear dynamics. Here, we inv

Bokkapitel i Handbook of Nuclear Medicine and Molecular Imaging for Physicistsutoradiography is defined as technologies and methods used to produce a two-dimensional image of the distribution of activity in, or on, a thin and solid sample that is in close proximity to the detector. The images are usually formed by charged particles (α or β±), and image characteristics are determined both by the detector and the properties of the particles detected. This method is not widely

In a community effort to combat sample mislabeling in multi-omic studies, computational solutions received show a wide range of accuracy. The final collaborative product, COSMO, achieves high performance. Applying COSMO to published datasets demonstrates biological impact of the tool.Sample mislabeling or misannotation has been a long-standing problem in scientific research, particularly prevalent in large-scale, multi-omic studies due to the complexity of multi-omic workflows. There exists an urgent need for implementing quality controls to automatically screen for and correct sample mislabels or misannotations in multi-omic studies. Here, we describe a crowdsourced precision

BACKGROUND: The use of brief cognitive screening instruments is essential in the assessment of dementia. The purpose of this study is to determine the frequency of use and perceived characteristics of cognitive screening instruments among Canadian psychogeriatric clinicians.METHODS: Members of the Canadian Academy of Geriatric Psychiatry (CAGP) and attendees to the 2010 Annual Scientific Meeting w

Slope stability is an important aspect in the management of civil engineering projects. The stability of earth slopes is a significant concern for safety and the economy. There are several methods for finding the safety factor. Spencer's method is considered one of the most accurate methods for calculating the factor of safety but it depends on the others on dividing the slope geometry into the nu

Risk assessments are often performed at multiple system levels in order to inform decision-making; for example, on multiple levels within an organization or on multiple societal levels. One way to conduct risk assessments on the higher system levels is to utilize and aggregate risk information from the lower level assessments. However, the process of aggregating risk information can be highly comp

The cultivation of ethnographic discovery is not only about being insightful in the field by paying attention to unexpected events and unforeseen social processes. We should also search for potentially surprising or disturbing findings after the fieldwork. This can provide additional ways to create an original and sustainable understanding of research material. In this chapter, we discuss a study

The structural research programmes of the European Union dedicated to advance thesustainability sciences are increasingly permeated by thenotion of transdisciplinarity (TD). A growing body of literature residing at the intersection of research methodology and sustainability studies can guide researchers to adopt appropriate research approaches in their projects. However, how to implement the trans

Surrogate measures of safety (SMoS) are meant to be an alternative/complement to crash data that enables a proactive approach to traffic safety. Validity is a fundamental property of SMoS that describes how well they reflect the quality of interest – traffic safety. However, typical validation studies are extremely resource demanding. Therefore, the aim of this study was to explore a relative appr

Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a broad-specificity methyltransferase that mediates the formation of the majority of 1MH present in mo

We study the macroscopic dynamics of large networks of excitable type 1 neurons composed of two populations interacting with disparate but symmetric intra- and inter-population coupling strengths. This nonuniform coupling scheme facilitates symmetric equilibria, where both populations display identical firing activity, characterized by either quiescent or spiking behavior, or asymmetric equilibria

Screening for severe combined immunodeficiency (SCID) was introduced into the Swedish newborn screening program in August 2019 and here we report the results of the first year. T cell receptor excision circles (TRECs), kappa-deleting element excision circles (KRECs), and actin beta (ACTB) levels were quantitated by multiplex qPCR from dried blood spots (DBS) of 115,786 newborns and children up to