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Mesenchymal stromal cells (MSCs) have been shown to have useful properties for cell therapy and have been proposed for treatment of neurodegenerative diseases, including Parkinson’s disease. However, the mechanisms involved in recovering dopaminergic neurons are not clear. The present study aims to evaluate the pathways and molecules involved in the neuroprotective effect of MSCs. We analyzed the

Recent technologies of district heating and cooling (DHC) systems integrate renewable energy sources and connect multiple heat producers and consumers to the same network. The resulting interactions may therefore cause the fluid in the pipe, or the energy carried by the system, to flow in both directions. This article presents a newly developed analytical method for evaluating the hydraulic states

This chapter discusses how the official religious policies stipulated in the so-called Document 19 issued by the Central Committee of the Chinese Communist Party in 1982 have transformed into the current religious laws and policies under Xi Jinping. Therefore, it analyses the most recent amendment (2017) of the Religious Affairs Regulations (RAR), Administrative Measures for Religious Groups (2020

At MAX IV laboratory the linac is used to inject into the two rings but also to drive the FemtoMAX beamline, which is a source of (incoherent) short pulses in the Hard X-ray range.In this contribution we present the design and simulations for a new mode of operation of the linac that would allow to generate coherent ultra-short FEL pulses in the soft X-ray domain. Preliminary simulations indicate

In certain situations, the quality of a process is determined by dependent variables in relation to independent variables, often modeled through a regression framework referred to as a profile. The practice of monitoring and preserving this relationship is known as profile monitoring. In this paper, we propose an innovative approach that uses different machine-learning (ML) techniques for construc

The rapid proliferation of data across diverse fields has accentuated the importance of accurate imputation for missing values. This task is crucial for ensuring data integrity and deriving meaningful insights. In response to this challenge, we present Xputer, a novel imputation tool that adeptly integrates Non-negative Matrix Factorization (NMF) with the predictive strengths of XGBoost. One of Xp

Nutrient enrichment is an increasingly important consequence of anthropogenic activities. Nutrient enrichment can alter the composition, diversity, and functioning of terrestrial plant communities, yet its effect on evolutionary processes in plant populations has been less well studied. To understand the evolutionary consequence of long-term soil nutrient enrichment, we examine the effects of nutr

After a long period of being constructed as anonymous administration complexes, first instance courts are once again being built as emblematic elements of the city, designed by renowned architects and rising up on central plots adjacent to train stations, headquarter buildings and exclusive residential areas. This is happening at a time of centralisation, upsizing and property privatisation, and w

Pathogenic variants in KIAA0586/TALPID3 are associated with the ciliopathy Joubert syndrome (JS). We report individuals with KIAA0586/TALPID3 variants affected by primary and motile cilia defects leading to JS and chronic destructive airway disease. DNA variants were detected in three families by sequencing. In two unrelated families, a deep-intronic variant (KIAA0586/TALPID3:c.3990 + 3186G>A) act

This chapter is an exploration of the concept of periphery when applied to regions. Specifically, it unpacks what we mean when we talk about places, specifically regions, as “peripheral”. It does this from the perspective of a sub-discipline of human geography: regional economic geography. In this field, peripheral regions are becoming increasingly interesting to researchers due to their key roles

The study aimed to examine whether children’s school absenteeism affects parents in terms of their well-being, communication, and everyday life. The sample was collected using convenience sampling, and the studied population consisted of parents in Sweden with children under the age of 18 attending elementary or upper secondary school. The study was conducted through a quantitative method, and the

Anemia is a common problem when patients present with cancer, and it can worsen during treatment. Anemia can directly impact the cognitive and physical quality of life and may impair fitness for oncological therapy. The most common cause of anemia is iron deficiency. Newer intravenous (IV) iron formulations offer a safe and rapidly effective treatment option. We performed a systematic mapping revi

In recent years, the automotive industry has increasingly prioritized comfort to meet rising consumer expectations for luxurious car experiences. Comfort, a subjective concept associated with well-being and relaxation, encompasses multidimensional aspects rooted in physical, psychological, and functional aspects. While existing comfort models focus mainly on seated positions and sensations like fa

The estimation of regression parameters in spatially referenced data plays a crucial role across various scientific domains. A common approach involves employing an additive regression model to capture the relationship between observations and covariates, accounting for spatial variability not explained by the covariates through a Gaussian random field. We study the effect of misspecified covariat