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Objective: The atrioventricular (AV) node plays a central role in atrial fibrillation (AF) as it influences the conduction of impulses from the atria into the ventricles. In the present paper, the statistical dual pathway AV node model, previously introduced by us, is modified so that it accounts for atrial impulse pathway switching even if the preceding impulse did not cause a ventricular activat

Objective: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS). Methods: We performed a GWAS with >5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European center

The exploration of exotic nuclei is one of the most intriguing and fastest expanding fields in modern nuclear physics. In the extreme conditions of unsymmetric neutron-proton distributions and small binding energies many nuclear phenomena not encountered closer to stability have revealed themselves, often as a surprise to the nuclear physics community, the prime example being the development of ha

The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs remains one of the key challenges in cancer research. Despite its relevance, no efficient study designs to identify promising candidate biomarkers have been established. This has led to the proliferation of a myriad of exploratory studies using dissimilar strategies, most of which fail to identify any promisi

Cell replacement therapy in Parkinson’s disease (PD) still lacks a study addressing the acquisition of electrophysiological properties of human grafted neural stem cells and their relation with the emergence of behavioral recovery after transplantation in the short term. Here we study the electrophysiological and biochemical profiles of two ventral mesencephalic human neural stem cell (NSC) clonal

Informal caregivers have a leading role when implementing health care services for people with cognitive disorders living at home. This study aims to examine the current evidence for interventions with dual satisfaction with health care services for people with cognitive disorders and their caregivers. Original papers with quantitative and mixed method designs were extracted from two databases, co

A long line of research has studied the power of conflict- driven clause learning (CDCL) and how it compares to the resolution proof system in which it searches for proofs. It has been shown that CDCL can polynomially simulate resolution even with an adversarially chosen learning scheme as long as it is asserting. However, the simulation only works under the assumption that no learned clauses are

Diffusion encoding along multiple spatial directions per signal acquisition can be described in terms of a b-tensor. The benefit of tensor-valued diffusion encoding is that it unlocks the 'shape of the b-tensor' as a new encoding dimension. By modulating the b-tensor shape, we can control the sensitivity to microscopic diffusion anisotropy which can be used as a contrast mechanism; a feature that

Prosodic prominence is a multimodal phenomenon where pitch accents are frequently aligned with visible movements by the hands, head, or eyebrows. However, little is known about how such movements function as visible prominence cues in multimodal speech perception with most previous studies being restricted to experimental settings. In this study, we are piloting the acquisition of multimodal promi

Recent research showed that exposure to the vaccine against polio in early life had no long-term economic benefits among native Swedes. However, whether this result holds for individuals from other countries remains unexplored. This study explores the relationship between exposure to the vaccine and later-life outcomes, but focuses on individuals who migrated to Sweden (birth cohorts 1946-1971), w

Emerging technologies open the prospect of extraordinary interventions on the human body. These may go beyond what is strictly necessary to sustain health and well-being. While responding to social and ethical challenges of such advances, the Law simultaneously faces the challenge of reflecting on the legitimacy to legislate and on whether the existing legal framework is appropriate to address the

Interactions between cortical areas were studied during the search for verbal associations and reading of words. The functional anatomy and the sequence of involvement of cortical areas during the solution of these tasks have been described previously, in studies using positron emission tomography and multichannel recordings of evoked potentials combined with identification of the locations of dip

A new parameterization for calculating the nonlinear near-bed wave orbital velocity in the shallow water was presented. The equations proposed by Isobe and Horikawa (1982) were modified in order to achieve more accurate predictions of the peak orbital velocities. Based on field data from Egmond Beach in the Netherlands, the correction coefficient and maximum skewness were determined as functions o

Policies aimed at sustainable landscape management recognise the importance of multiple cultural viewpoints, but the notion of landscape itself is implicitly assumed to be homogeneous across speech communities. We tested this assumption by collecting data about the concept of “landscape” from speakers of seven languages of European origin. Speakers were asked to freely list exemplars to “landscape

Airborne particle emissions from automotive disc brakes, one of the main sources of urban particulate matter, adversely affect health. Field measurement of brake particles is complicated, as various particle sources (such as tailpipe emissions, resuspended road dust and tyre wear) can interfere. Brake particles are usually measured on dyno benches or in model-scale tests in controlled environments