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The Greatwall kinase/Mastl is an essential gene that indirectly inhibits the phosphatase activity toward mitotic Cdk1 substrates. Here we show that although Mastl knockout (MastlNULL) MEFs enter mitosis, they progress through mitosis without completing cytokinesis despite the presence of misaligned chromosomes, which causes chromosome segregation defects. Furthermore, we uncover the requirement of

BACKGROUND: Patients with platinum-sensitive recurrent ovarian cancer are a heterogeneous group, and it is not possible to accurately predict the progression-free survival (PFS) in these patients. We developed and validated a nomogram to help improve prediction of PFS in patients treated with platinum-based chemotherapy.METHODS: The nomogram was developed in a training cohort (n=955) from the CALY

Massive parallel sequencing (MPS) is increasingly used for human identification purposes in forensic DNA laboratories. Forensic DNA samples are by nature heterogeneous and of varying quality, both concerning DNA integrity and matrices, creating a need for assays that can handle low amounts of DNA as well as impurities. Commercial short tandem repeat (STR) analysis kits for capillary electrophoresi

The time delay estimation problem associated with an ensemble of misaligned, repetitive signals is revisited. Each observed signal is assumed to be composed of an unknown, deterministic signal corrupted by Gaussian, white noise. This paper shows that maximum likelihood (ML) time delay estimation can be viewed as the maximization of an eigenvalue ratio, where the eigenvalues are obtained from the e

This study is carried out by using numerical simulations to investigate the effect of target surface curvature and the nozzle-to-target surface distance on the flow structure and heat transfer characteristics in a pin-finned double-wall cooling structure. The flow is directly impinging on the target surface and is disturbed by the pin fins, and then released from the film holes after passing the d

Stakeholder interaction is important for enabling environmental research to support the societal transition to sustainability. We argue that it is crucial to take researchers’ approaches to and perceptions of stakeholder interaction into account, to enable more clarity in discussions about interaction, as well as more systematic interaction approaches. Through a survey and focus group interviews w

The construction, operation and maintenance of transportation infrastructure require energy and materials which impact the environment. Large infrastructure projects thus use resources intensively and leave a significant environmental footprint. To demonstrate and support the sustainability of such large-scale projects, life cycle assessment (LCA) has become a common tool to evaluate environmental

Machine learning is a powerful technique, becoming increasingly popular in astrophysics. In this paper, we apply machine learning to more than a thousand globular cluster (GC) models simulated with the mocca-Survey Database I project in order to correlate present-day observable properties with the presence of a subsystem of stellar mass black holes (BHs). The machine learning model is then applied

A large strand of research holds that democracy with its broad representation and electoral accountability is beneficial for the provision of public goods. Yet, there is a large variation in how democracies perform, indicating that democratic institutions alone do not suffice for securing citizens’ wellbeing. Recent studies have stressed the equal importance of state capacity for public goods deli

A questionnaire survey has been conducted in Belgium, Denmark, Germany, Poland, Spain and Sweden in 2016­2017. Once every third month through one year respondents have received a link to an online questionnaire which asked them about information on any traffic accidents they might have experienced in the period. The questionnaire contains questions on various aspects related to the accidents that

Two approximation methods are presented for fast calculations of the monostatic scattering from axially symmetric scatterers coated with electromagnetic absorbers. The methods are designed for plane wave illumination parallel to the axis of rotation of the scatterer. The first method is based on simulating the scattering of a perfect electric conductor (PEC) enclosing the absorber coated scatterer