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Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue tumor primarily affecting children and young adults. Most cases display a pathognomonic EWSR1-WT1 gene fusion, presumably constituting the primary driver event. Little is, however, known about secondary genetic changes that may affect tumor progression. We here studied 25 samples from 19 DSRCT patients using single nucl
The meteoritic material falling on Earth is believed to derive from large break-up or cratering events in the asteroid belt. The flux of extraterrestrial material would then vary in accordance with the timing of such asteroid family-forming events. In order to validate this, we investigated marine sediments representing 15 time-windows in the Phanerozoic for content of micrometeoritic relict chrom
I denna studie görs en uppdaterad analys av den länsvisa tillgången på skogsbaserade rest- och biprodukter i form av grenar och toppas (grot) vid föryngringsavverkningar, bark från sågverk och massabruk, sågspån (och kutterspån) från sågverk samt lignin från svartlut i sulfatmassabruk som råvara för framtida produktion av biodrivmedel/bioflygbränsle. Analysen inkluderar också beräkningar av teoretThis study includes an updated analysis of the regional potential of forest-based residues and by-products in form of logging residues after final felling’s, bark in sawmills and pulp mills, sawdust in sawmills, and lignin from black liquor in pulp mills, as feedstocks for future production of biofuels and biojet fuels. The analysis also include calculations of theoretical transportation distances
The conterminous marine system of the Bering Sea serves as an important connection between the Pacific and the Arctic. Surface water temperatures of the Northern Pacific have been rising over the past decades with associated changes in extremes: marine heatwaves (MHWs). This study aims to explore the spatiotemporal evolution characteristics and occurrence mechanisms of MHWs in the Bering Sea. Our
Scientists are increasingly exploring on-site water systems to supplement conventional centralized water and wastewater infrastructure. While major technological advancements have been achieved, we still lack a systematic view on the non-technical, or institutional, elements that constitute important barriers to the uptake of on-site urban water management systems. This paper presents a conceptual
RNA viruses have gained plenty of attention during recent outbreaks of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Zika virus (ZIKV), and Ebola virus. ZIKV is a vector borne Flavivirus that is spread by mosquitoes and it mainly infects neuronal progenitor cells. One hallmark of congenital ZIKV disease is a reduced brain size in fetuses, leading to severe neurological defects. The
Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis profoundly attenuates atherosclerosis. As CD40L exerts multiple functions depending on the cell-cell interactions involved, we sought to investigate the function of the most relevant CD40L-expressing cell types in atheroscleros
The relationship between geographical and social forms of remoteness and the concepts of vulnerability and capacity remains unclear. Recognising that capacities and vulnerabilities tend to co-exist in a population, the article assumes that the dynamics between these concepts are situational. In this article we draw on three cases to analyse the issue. An Arctic case study provides insight on remot
Reconstruction of nerve defects is a clinical challenge. Autologous nerve grafts as the gold standard treatment may result in an incomplete restoration of extremity function. Biosynthetic nerve conduits are studied widely, but still have limitations. Here, we reconstructed a 10 mm sciatic nerve defect in healthy rats and analyzed nerve regeneration in poly (ɛ‐caprolactone) (PCL) conduits longitudi
The oxidation of ammonia is a key reaction for the production of artificial fertilizers and for environmental protection. Depending on the area of application, the catalytic reaction needs to be tuned toward the production of either N2 or NO, and this selectivity is controlled by temperature, pressure, reactant ratio, and the type of catalyst. PtRh alloys are highly useful catalytic materials for
Cities are expected to contribute to climate mitigation by providing effective climate policy actions in a multilevel governance context. Yet, it is unclear what we actually know about the strengths and weaknesses of urban climate policy measures and how municipal policy learning could be enhanced. In this article we present a comprehensive review on cities’ experience in climate mitigation policy
Significance: Despite remarkable advances in the core modalities used in combating cancer, malignant diseases remain the second largest cause of death globally. Interstitial photodynamic therapy (IPDT) has emerged as an alternative approach for the treatment of solid tumors. Aim: The aim of our study is to outline the advancements in IPDT in recent years and provide our vision for the inclusion of
Proteins evolve under a myriad of biophysical selection pressures that collectively control the patterns of amino acid substitutions. These evolutionary pressures are sufficiently consistent over time and across protein families to produce substitution patterns, summarized in global amino acid substitution matrices such as BLOSUM, JTT, WAG, and LG, which can be used to successfully detect homologs
Background. During the translation of mRNA into polypeptide, elongation factor G (EF-G) catalyzes the translocation of peptidyl-tRNA from the A site to the P site of the ribosome. According to the 'classical' model, EF-G in the GTP-bound form promotes translocation, while hydrolysis of the bound GTP promotes dissociation of the factor from the post-translocation ribosome. According to a more recen
A procedure for spectroscopic characterization and partial fractionation of human protein HC populations by high-performance liquid chromatography-photodiode array ultraviolet-visible detection is reported. Human protein HC from urine or amniotic fluid fractionated by anion-exchange HPLC in a protein Pak DEAE 5PW appeared to be heterogeneous as judged by the asymmetric elution pattern, consisting
