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Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to retreatment present continuing areas for research. The disease and its effective treatment are associa

The recycling, S-nitrosylated heparan sulfate (HS) proteoglycan glypican-1 releases anhydromannose (anMan)-containing HS chains by a nitrosothiol-catalyzed cleavage in endosomes that can be constitutive or induced by ascorbate. The HS-anMan chains are then transported to the nucleus. A specific nuclear target for HS-anMan has not been identified. We have monitored endosome-to-nucleus trafficking o

In this work, the potential of combining capillary electrophoresis-time-of-flight-mass spectrome-try (CE-TOF-MS) and Fourier transform-ion cyclotron resonance-mass spectrometry (FT-ICR-MS) for metabolomics of genetically modified organisms (GMOs) is demonstrated. Thus, six different varieties of maize, three of them transgenic (PR33P66 Bt, Tietar Bt and Aristis Bt) and their corresponding isogenic

The mechanisms that specify photoreceptor cell-fate determination, especially as regards to short-wave-sensitive (S) versus medium-wave-sensitive (M) cone identity, and maintain their nature and function, are not fully understood. Here we report the importance of general transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) in maintaining M cone cell identity and function as well

BACKGROUND: The study investigated whether 3D vision and haptic feedback in combination in a virtual reality environment leads to more efficient learning of laparoscopic skills in novices.MATERIAL AND METHODS: Twenty novices were allocated to two groups. All completed a training course in the LapSim(®) virtual reality trainer consisting of four tasks: 'instrument navigation', 'grasping', 'fine dis

The TIMESAT software package has been developed to enable monitoring of dynamic land surface processes using remotely sensed data. The monitoring capability is based on processing of time-series for each image pixel using either of three smoothing methods included in TIMESAT: asymmetric Gaussian fits, doublelogistic fits, and Savitzky-Golay filtering. The methods have different properties and are

Syftet med uppsatsen är att med hjälp av en rättsdogmatisk metod undersöka hur samhället skyddar de flickor som utsätts för hedersrelaterat våld och förtryck. I uppsatsen beskrivs centrala begrepp inom hederskulturen och hur hedersrelaterat våld och förtryck kan ta sig uttryck. Uppsatsen undersöker möjligheterna för omhändertagande av unga enligt LVU med anledning av det hedersrelaterade våldet ocThe purpose of this essay is to investigate how our society protects young girls who are victims of honor-related violence and oppression. The essay describes key concepts in honor-based cultures and how honor-related violence and oppression can be expressed. The essay examines the possibilities for a young person to be cared for according to LVU because of honor-related violence. The essay descri

Studiens huvudsakliga syfte var att undersöka hur väl psychological safety i arbetslaget hos brandmän och styrkeledare statistiskt kan predicera upplevda krav, kontroll, stöd och stress på arbetet samt symptom på utmattningssyndrom. Studien ämnade även undersöka förekomst av psychological safety, stress, symptom på utmattning och iso-spänt arbete i urvalspopulationen samt huruvida demografiska fråThe study aimed to examine how well psychological safety in teams of firefighters could predict perceived demands, control, support and stress at work as well as symptoms of exhaustion. The study further examined the prevalence of psychological safety, stress, symptom of exhaustion and iso-strained work and whether demographical data predicts prevalence of psychological safety. The design was cros

Flexible parking requirements have been introduced in several Swedish city governments in recent years. Through qualitative interviews with traffic engineers, learnings from these years have been compiled and then compared with a literature review. The flexibility de-sign and required mobility management measures varies from detailed to free, and results show that different engineers prefer differ

This essay explores how a critical reading of the novel The Grapes of Wrath (1939) can inform teachers when discussing inequality issues in the ESL classroom. The main questions being investigated are how the novel The Grapes of Wrath reveals oppressive and unequal power relationships, and how a critical reading of the novel can be used when teaching and informing others about inequality. In this

The Mesopotamian Marshlands form one of the first landscapes where people started to transform and manipulate the natural environment in order to sustain human habitation. For thousands of years people transformed natural ecosystems into agricultural fields, residential clusters and other agglomerated environments to sustain long term settlement. Moreover, the Mesopotamian Marshlands, located in o

Denna uppsats redogör för förhållandet mellan kulturella normer och svensk straffrätt. Först genom att analysera ämnet från ett de lega lata-perspektiv och sedan från ett de lega ferenda-perspektiv. De lega lata-utredningen analyserar delar av straffrättens allmänna del och allmänna bestämmelser såsom regeringsformens bestämmelser med koppling till kultur och minoriteter. Resultatet visar att strThis essay investigates the relationship between cultural norms and Swedish criminal law. The analysis is performed by discussing the topic from a lex lata perspective and then from a lex ferenda perspective. The lex lata portion analyzes sections of the general part of criminal law, the legislator’s integration goals and the Instrument of Government’s articles on culture and minorities. The resu

The inclusion of car-sharing services into new residential areas has lately been introduced in several places around Sweden. This case study reviews car-sharing in new residential areas in the city of Malmö; in the central area of Fullriggaren and the more peripheral area of Kalkbrottet. The study seeks to explain the importance of local conditions and local policies for the establishment of car-s