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Objective: To assess whether there is an association between total prescribed dosage of resistance exercise (volume, frequency, intensity, and duration) and change in pain and physical function in individuals with knee osteoarthritis (OA). Method: A systematic review with meta-regression was conducted, searching MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials until December
The X-ray flux from X-ray free-electron lasers and storage rings enables new spatiotemporal opportunities for studying in-situ and operando dynamics, even with single pulses. X-ray multi-projection imaging is a technique that provides volumetric information using single pulses while avoiding the centrifugal forces induced by conventional time-resolved 3D methods like time-resolved tomography, and
Drawing from socio-legal studies on technological governance and notions of the pacing problem between law and new technologies, this chapter addresses how generative AI is regulated in the EU AI Act. Specifically, it focuses on implications of the two-tiered approach to General Purpose Artificial intelligence (GPAI) models, where the top tier is adding obligations to producers of so-called “syste
Aim: To describe healthcare utilization patterns among older people with intellectual disabilities in comparison to that of their age peers in the general population, including possible changes due to the COVID-19 pandemic. Subjects and methods: This was a Swedish longitudinal, register-based cohort study comprising 766 people aged 65+ years with intellectual disabilities (ID cohort) and 257 285 s
Despite their ecological and economic importance as key regulators of insect populations worldwide, eulophid wasps remain one of the taxonomically most neglected groups of insects. As these minute parasitoid wasps exhibit an astonishing species diversity while being challenging to identify, relying on morphological characters alone has long been problematic. By using large-scale barcoding and mole
OBJECTIVES: To evaluate if ileo-psoas muscle size and visceral adipose tissue (VAT) can predict long-term survival after endovascular aneurysm repair (EVAR). METHODS: Patients who underwent EVAR between 2004 and 2012 in a single centre were included. Total psoas muscle area (TPA), abdominal VAT area, subcutaneous adipose tissue (SAT), and total adipose tissue were measured on the preoperative CT.
Both trio and population designs are popular study designs for identifying risk genetic variants in genome-wide association studies (GWASs). The trio design, as a family-based design, is robust to confounding due to population structure, whereas the population design is often more powerful due to larger sample sizes. Here, we propose KnockoffHybrid, a knockoff-based statistical method for hybrid a
This paper investigates the aeroacoustic properties of dual-stream co-axial supersonic jets, focusing on sound generation at the engine nozzle exit, which significantly contributes to cabin noise in supersonic civil aviation. The study delves into three primary noise-generating mechanisms present in supersonic jets: broadband shock-associated noise, jet screech, and turbulent mixing noise. While s
The COVID-19 crisis noted many reports of dramatic price increases of essential items such as face masks, hand sanitisers and disinfectants. Already in March 2020 the Competition Authorities in Europe, by way of a joint statement by European Competition Network and individual public announcements, cautioned against price gouging practices and re-affirmed their commitment to pursue such practices v
Not receiving a DPT-containing vaccine in early childhood indicates an absence of routine immunization, which puts children at an elevated risk of mortality, morbidity, and worse human development over the life course. We estimated the percentage of children 12-35 months who did not receive a dose of DPT-containing vaccine (termed zero-dose children) using household surveys from 81 low- and middle
Introduction: Cerebrovascular reactivity imaging (CVR) is a diagnostic method for assessment of alterations in cerebral blood flow in response to a controlled vascular stimulus. The principal utility is the capacity to evaluate the cerebrovascular reserve, thereby elucidating autoregulatory functioning. In CVR, CO2 gas challenge is the most prevalent method, which elicits a vascular response by al
Objective. Despite the growing interest in understanding the role of triggers of paroxysmal atrial fibrillation (AF), solutions beyond questionnaires to identify a broader range of triggers remain lacking. This study aims to investigate the relation between triggers detected in wearable-based physiological signals and the occurrence of AF episodes. Approach. Week-long physiological signals were co
Background. Pain is common in Parkinson's disease (PD) and impairs quality of life. The King's PD pain questionnaire (KPPQ) is a standardized, reliable, and valid self-administered questionnaire for screening of pain in PD. We developed a linguistically validated German version of the KPPQ and applied it to a cohort with fluctuating PD. Methods. The interculturally adapted German translation was p
Accessible housing plays a crucial role in supporting aging in place, yet Japan lacks adequate tools for assessing housing accessibility among older adults. This study describes the process of translating and adapting the environmental component checklist of the Swedish Housing Enabler instrument for valid use in Japan. During translation to the Japanese language, technical terms and specification
Introduction: Increased theta and delta power and decreased alpha and beta power, measured with quantitative electroencephalography (EEG), have been demonstrated to have utility for predicting the development of dementia in patients with Parkinson’s disease (PD). Noradrenaline modulates cortical activity and optimizes cognitive processes. We claim that the loss of noradrenaline may explain cogniti
A chemical proteomics approach using Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor–immobilized sepharose (TIM-063-Kinobeads) identified main targets such as CaMKKα/1 and β/2, and potential off-target kinases, including AP2-associated protein kinase 1 (AAK1), as TIM-063 interactants. Because TIM-063 interacted with the AAK1 catalytic domain and inhibited its enzymatic activity m
In order to change consumption patterns into something that is more sustainable, it is essential that we consider the various and conflicting meanings clothes have in people's lives. This article presents an analysis of diaries written by consumers of different ages and occupations over a period of three months in 2015. These consumers documented their clothing and shoe purchases, took inventory o
