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α-Synuclein (α-Syn), is an intrinsically disordered protein present in the substantia nigra part of the brain. α-Syn is commonly known to associate with lipid membranes containing anionic lipids. Hence, the protein is hypothesized to be involved in the vesicle trafficking at the synapses, but there are yet many unanswered questions regarding the full physiological role of the protein. During the d
Background and aims: Appendectomy has historically been the standard treatment of acute appendicitis, but lately, conservative treatment of uncomplicated acute appendicitis with antibiotics has successfully been used in selected patients. Complicated acute appendicitis is often treated conservatively initially, but may benefit from interval appendectomy due to the higher risk ofappendiceal maligna
Rapid urbanization has placed the sustainable development of some watershed ecosystems in jeopardy. In order to achieve sustainable urban development, it is vital to identify the coupling mechanisms between urbanization and the ecological environment quality. This study establishes indicators to evaluate the Jiulong River Basin’s urbanization and ecological environment systems. These are utilized
PhD training in academic labs offers the foundation for the production of frontier knowledge workers, indispensable for the modern knowledge-based society. Nonetheless, our understanding on PhD training has been insufficient due to limited access to the inside of academic labs. Furthermore, early careers of PhD graduates are often difficult to follow, which makes the evaluation of training outcome
SUMMARY: Antibody repertoires reveal insights into the biology of the adaptive immune system and empower diagnostics and therapeutics. There are currently multiple tools available for the annotation of antibody sequences. All downstream analyses such as choosing lead drug candidates depend on the correct annotation of these sequences; however, a thorough comparison of the performance of these tool
We aimed to evaluate the clinical utility of stationary tissue background phase correction for affecting precision in the measurement of Qp/Qs by cardiovascular magnetic resonance (CMR). We enrolled consecutive patients (n = 91) referred for CMR at 1.5T without suspicion of cardiac shunt, and patients (n = 10) with verified cardiac shunts in this retrospective study. All patients underwent phase c
Local infection control measures, antibiotic consumption and patient demographics from 1999-2000 together with bacteriological analyses were investigated in 29 ICUs participating in the ICU-STRAMA programme. The median antibiotic consumption per ICU was 1147 (range 605-2143) daily doses per 1000 occupied bed d (DDD1000). Antibiotics to which >90% of isolates of an organism were susceptible were de
Climate change has made urban decarbonisation a global imperative. Cities are both a source of emissions and a leverage-point for the necessary transformation processes. Iceland is blessed with an ample supply of renewable energy sources. Hydropower and geothermal are widespread in the country and they dominate the country’s electricity and district heating systems. Despite this huge potential, pe
Objectives: Peripartum cardiomyopathy (PPCM) is a rare disease carrying a risk of death and chronic heart failure.It is unknown if women with PPCM have a family history of heart failure. We investigated the prevalence of heart failure and hypertension in first-degree relatives to women with PPCM. Methods: A cohort of 61 women with PPCM was identified through the nationwide Danish registers from 20
Water resources are under increasing pressure, and there are tensions between increasing demand and the natural limits to potable water supply. Authorities must find solutions that fulfil societal demands without compromising environmental integrity. As one way to counteract water deficits, desalination has evolved as an attractive solution. This technology is contested and associated with a varie
Kolloider, partiklar i storleksordningen en nanometer till en mikrometer, är inom materialvetenskapen attraktiva byggstenar vid konstruktion av olika material eftersom de spontant organiserar sig i periodiska strukturer. Till skillnad från biologiska kolloider såsom proteiner, röda blodkroppar, bakterier och virus, är de syntetiska kolloider som man har tillgång till inom materialvetenskapen i regColloidal self-assembly is an attractive bottom-up approach to new superstructures and materials with new properties. However, the typical spherical shape and isotropic interaction potential limit the repertoire of ordered structures that can be obtained from synthetic colloids. In order to expand the repertoire of structures, much effort has over the last decades been directed towards the prepara
Background: Norovirus is frequently introduced to the hospital and is a frequent cause of hospital outbreaks. Recognition of the factors that facilitate or impede norovirus transmission is an important step to effectively prevent hospital outbreaks. Aim: To investigate risk factors for norovirus outbreaks in hospital settings. Methods: Clinical data, ward setting, and norovirus genotype were colle
Objective: The aim of this study was to investigate the awareness of palliative care (PC) in a general Swedish population. Design: We developed an e-survey based on a similar study conducted in Northern Ireland, consisting of 10 questions. Closed questions were primarily analyzed using descriptive statistics. Open questions were subject to inductive qualitative analysis. Subjects: The study utiliz
Background: This prospective study focuses on factors associated with arterial damage in children with type 1 diabetes (T1D). Materials and Methods: Eighty children and adolescents with T1D (mean age 15, range: 8-20 yrs; mean diabetes duration 7, range: 0.5 to 19 years) were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow
Background. Lowe syndrome (LS) and Dent-2 disease (DD2) are disorders associated with mutations in the OCRL gene and characterized by progressive chronic kidney disease (CKD). Here, we aimed to investigate the long-term renal outcome and identify potential determinants of CKD and its progression in children with these tubulopathies. Methods. Retrospective analyses were conducted of clinical and ge
