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Both trio and population designs are popular study designs for identifying risk genetic variants in genome-wide association studies (GWASs). The trio design, as a family-based design, is robust to confounding due to population structure, whereas the population design is often more powerful due to larger sample sizes. Here, we propose KnockoffHybrid, a knockoff-based statistical method for hybrid a

OBJECTIVES: To evaluate if ileo-psoas muscle size and visceral adipose tissue (VAT) can predict long-term survival after endovascular aneurysm repair (EVAR). METHODS: Patients who underwent EVAR between 2004 and 2012 in a single centre were included. Total psoas muscle area (TPA), abdominal VAT area, subcutaneous adipose tissue (SAT), and total adipose tissue were measured on the preoperative CT.

Understanding the relation between enzyme domain structure and catalytic activity is crucial for optimal engineering of novel enzymes for lignocellulose bioconversion. Xylanases with varying specificities are commonly used to valorise the hemicellulose arabinoxylan (AX), yet characterization of specific arabinoxylanases remain limited. Two homologous GH5_34 arabinoxylanases, HhXyn5A and CtXyn5A, i

The COVID-19 crisis noted many reports of dramatic price increases of essential items such as face masks, hand sanitisers and disinfectants. Already in March 2020 the Competition Authorities in Europe, by way of a joint statement by European Competition Network and individual public announcements, cautioned against price gouging practices and re-affirmed their commitment to pursue such practices v

Not receiving a DPT-containing vaccine in early childhood indicates an absence of routine immunization, which puts children at an elevated risk of mortality, morbidity, and worse human development over the life course. We estimated the percentage of children 12-35 months who did not receive a dose of DPT-containing vaccine (termed zero-dose children) using household surveys from 81 low- and middle

Introduction: Cerebrovascular reactivity imaging (CVR) is a diagnostic method for assessment of alterations in cerebral blood flow in response to a controlled vascular stimulus. The principal utility is the capacity to evaluate the cerebrovascular reserve, thereby elucidating autoregulatory functioning. In CVR, CO2 gas challenge is the most prevalent method, which elicits a vascular response by al

Kvinnas roll i samhället har historiskt genomgått en stor förändring, från att ansvara över hushållet till att etablera sig på arbetsmarknaden. Föräldraförsäkringen infördes år 1974 med syfte att möjliggöra för främst kvinnor att kombinera arbetsliv med familjebildning. Mäns uttag av föräldraförsäkringen har sedan införandet ökat, men fördelningen är fortfarande långt ifrån jämn. Kvinnor tar ut maWoman's role in society has historically undergone a great change, from the responsibility of the household to establishment in the labor market. Parental insurance was introduced in 1974 with the aim of enabling all women to combine work with family formation. Men's use of parental insurance has increased since the introduction, but the distribution is still far from consistent. Women tak

Målformulering: Examensarbetet primära mål är att påvisa att de byggentreprenörer som arbetar med BIM bidrar till ett effektivare arbetssätt och ekonomiskt mervärde. Detta genom att visa att en fundamental BIM-nytta såsom mängdavtagning är en ekonomisk vinning. Syfte: Syftet är att påvisa attmängdavtagningav väggar, bärande samt rumsbildande, inklusive dörrar och fönster via BIM är ett ekonomisktPurpose: The primary purpose is to demonstrate that constructors, which use BIM, contributes to a more efficient work and economic value to the process of construction projects. This, by showing that a fundamental use of BIM in "quantity take-off” is a financial gain. Furthermore, the study aims to evaluate how projects affected by the extent of BIM-use is in current situation. Additionally,

Skolan har ingen lång tradition av att arbeta laborativt i matematik och dynamisk programvara är ett sätt att fylla denna brist. Dynamisk programvara låter eleven gå i dialog, utmanar, skapar nyfikenhet, åskådliggör begrepp och underlättar inlärningen. Det krävs emellertid att lärare är villiga att sätta sig in i de relativt nya möjligheterna eftersom datoranvändning i matematik- och fysikundervisReportedly in Swedish schools, there is no long tradition of investigative and laboratory work in the mathematics subject. Dynamic software is a term which encapsulates the purpose of software as a pedagogical instrument in teaching. There is great potential in this but also a need for teachers to engage and apply themselves to the new possibilities. Computer software in class does not automatical

The aim of the study is to find a relation between the tip pressure produced by ram sounding and CPT in order to improve the possibilities of determining the shear strength of clay till. CPT is a pressure probe and mainly used to get a good picture of the statigraphy and the soil condition. CPT has shown to be useful regarding the evaluation of key parameters such as shear strengh and angle of fri

With a steady development of technology, the use of Model Predictive Control (MPC) has become more and more popular since the computation time has gone down. With this increase, a need for determining which MPC algorithm is good for solving a certain type of MPC problem has occurred which would facilitate the choice of algorithm and also could increase the performance. One of the determining aspec

Enligt svensk rätt ska utländska äktenskap erkännas om de är giltiga enligt lagen i det land de ingåtts. Undantaget till detta är om äktenskapet går emot svensk ordre public. Huruvida så är fallet för polygami är fortfarande osäkert. Det här arbetet kommer inte beröra huruvida Sverige bör ha en begränsning på antal äktenskap eller inte, utan fokus ligger på den svenska hanteringen av utländska pol

Korallodling i olika klimatzoner Jordens yta består till 70% av vatten och i många av dessa vatten finns korallrev. Vi människor har sedan länge levt på jordens resurser, men nu lever vi över de resurser som finns att tillgå. En indikator på det är förstörelsen av korallreven runt om i världen. Tack vare klimatförändringar, fiske, illegal handel, turism etc. är reven nu hotade och behöver hjälp fThis study is a quantitative content analysis of the coral gardening in different climate zones and its limitations and possibilities. The purpose of the study is to highlight the different approaches to coral gardening and whether these could be implemented in other climate zones. I will also highlight why coral gardening is important from an environmental perspective. To conduct the study, I hav

Den farliga bakterien som förorenar vår mat och gör oss sjuka Listeria monocytogenes, även vardagligt kallad endast listeria, är en bakterie som trivs och växer i miljöer där många andra bakterier inte kan växa. Listeria orsakar sjukdomen listerios, som är ganska ovanlig, men har en dödlighet på ca 20 – 30 %. Sjukdomen har på senare år blivit allt mer vanlig i Sverige. Som tur är finns det olika In this study the dangers of Listeria monocytogenes presence in food and the problem it creates for general food safety is presented. The aim of this study was to highlight the importance of food safety, especially when it concerns Listeria monocytogenes. The study should also give an insight to the part that Listeria monocytogenes plays among food and the risks that follows. Furthermore, it wil

The thesis focuses on the evolving relationship between art and its reproduction in the digital age on the one hand, and the contemporary observer on the other. The research focuses on art reproduction by means of virtual reality (VR) techniques, and delves into the history of art reproduction from antiquity to modern methods. It adopts a phenomenological approach, scrutinizing two case studies: R

Background Arriva DK currently has a decentralized organization where each depot is responsible for the inventory control of their spare parts. This type of organization often presents challenges when it comes to control and management. Arriva DK suffers from high order costs due to lack of coordination between the depots and the suppliers. To address these issues Arriva wants to introduce a centr