Filetype
BACKGROUND: Because parvovirus B19 infection in pregnancy has been associated with infant morbidity and mortality in case reports and after intrauterine transfusion, we tested the population-based association using serum and hospital data of high quality.METHODS: We established a cohort of 113 228 children born to women tested for parvovirus B19 infection during pregnancy in a major diagnostic lab
Studies of infection by Phytophthora infestans—the causal agent of potato late blight—in wild species can provide novel insights into plant defense responses, and indicate how wild plants might be influenced by recurrent epidemics in agricultural fields. In the present study, our aim was to investigate if different clones of Solanum dulcamara (a relative of potato) collected in the wild differ in
Molecular changes occurring during invasion and clinical progression of cancer are difficult to study longitudinally in patient-derived material. A unique feature of urothelial bladder cancer (UBC) is that patients frequently develop multiple nonmuscle invasive tumors, some of which may eventually progress to invade the muscle of the bladder wall. Here, we use a cohort of 73 patients that experien
Background: Prophylaxis with factor VIII (FVIII) should be individualized based on patient characteristics, including FVIII pharmacokinetics. Population pharmacokinetic (popPK) modeling simplifies pharmacokinetic studies by obviating the need for multiple samples. Objective: The objective of this study was to characterize the pharmacokinetics and inter-individual variability (IIV) of BAY 94-9027 i
Post-translational methylation of lysine side chains is of great importance for protein regulation, including epigenetic control. Here, we present specific 13CHD2 labeling of dimethylated lysines as a sensitive probe of the structure, interactions, and dynamics of these groups, and outline a theoretical and experimental framework for analyzing their conformational dynamics using 1H and 13C CPMG re
Geospatial information is indispensable for various real-world applications and is thus a prominent part of today’s data science landscape. Geospatial data is primarily maintained and disseminated through spatial data infrastructures (SDIs). However, current SDIs are facing challenges in terms of data integration and semantic heterogeneity because of their partially siloed data organization. In th
Avhandlingsarbetet studerar hur turbulent flödesstruktur sammverkar med förbränning av högoktaniga bränslen i partiellt förblandade förhållanden genom numeriska tredimensionella flödessimuleringar. Förbränningsmoder och antändningsprocesser studeras för två olika typfall där ett flertal metoder testas med ändamålet att korrekt återge hur icke upplöst rörelsemängd växelverkar med de kemiska processThis work treats the modelling of PPC engine combustion through 3D computational fluid dynamics. In order to develop a cost-effective CFD model for the design and performance analysis of PPC engines it is important to first understand the multiple modes of combustion in PPC engines, e.g., the onset of the first ignition kernels, the propagation of the ignition/flame fronts, and the effect of charg
Partially premixed combustion (PPC) is one of several advanced combustion concepts for the conventional diesel engine. PPC uses a separation between end of fuel injection and start of combustion, also called ignition dwell, to increase the mixing of fuel and oxidizer. This has been shown to be beneficial for simultaneously reducing harmful emissions and fuel consumption. The ignition dwell can be
Purpose: Comorbidity in stroke is common, but comprehensive reports are sparse. We describe prevalence of comorbidity and the prognostic impact on mortality and functional outcome in a large national ischemic stroke cohort. Methods: We used outcome data from a long-term follow-up survey conducted in 2016 by the Swedish Stroke Register (Riksstroke). Those included in the study were 11 775 pre-strok
Objective - T cell immunoglobulin and mucin domain (Tim) proteins are expressed by numerous immune cells, recognize phosphatidylserine on apoptotic cells, and function as costimulators or coinhibitors. Tim-1 is expressed by activated T cells but is also found on dendritic cells and B cells. Tim-4, present on macrophages and dendritic cells, plays a critical role in apoptotic cell clearance, regula
Syftet var att undersöka arbetsplatsrelationer som resurser för hälsa och välbefinnande från ett salutogent perspektiv. Antalet äldre människor ökar i befolkningen och äldreomsorgen har redan en ansträngd arbetsbörda, varför det är angeläget att ägna mer uppmärksamhet åt de salutogena aspekterna för arbetstagarna inom äldreomsorgen. Studierna utfördes inom en kommunal vård- och omsorgsorganisation
Stars formed in clusters can encounter other stars at close distances. In typical open clusters in the Solar neighbourhood containing hundreds or thousands of member stars, 10-20 per cent of Solar-mass member stars are expected to encounter another star at distances closer than 100 au. These close encounters strongly perturb the planetary systems, directly causing ejection of planets or their capt
Changes in the immune system induced by tyrosine kinase inhibitors (TKI) have been shown to positively correlate with therapy responses in chronic myeloid leukemia (CML). However, only a few longitudinal studies exist and no randomized comparisons between two TKIs have been reported. Therefore, we prospectively analyzed the immune system of newly diagnosed CML patients treated with imatinib (n = 2
Strategies to determine the removal efficiency of micropollutants in wastewater treatment plants (WWTPs) are widely discussed. Especially the evaluation of the potential benefit of further advanced treatment steps such as an additional tertiary treatment based on ozonation or activated carbon have come into focus. Such evaluation strategies are often based on the removal behavior of known micropol
