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BACKGROUND: We investigated the efficacy of rivaroxaban, an orally active direct factor Xa inhibitor, in preventing venous thrombosis after total knee arthroplasty.METHODS: In this randomized, double-blind trial, 2531 patients who were to undergo total knee arthroplasty received either oral rivaroxaban, 10 mg once daily, beginning 6 to 8 hours after surgery, or subcutaneous enoxaparin, 40 mg once
Sitagliptin has been suggested as a treatment option for older adults with type 2 diabetes (T2D). However, no randomized controlled trial has been performed to evaluate the efficacy and safety of sitagliptin treatment in older Japanese patients with T2D. The STREAM study was a multicenter, open-label, randomized controlled trial. T2D outpatients aged 65-80 years with moderately controlled glycemic
Large-scale bars can fuel galaxy centers with molecular gas, often leading to the development of dense ringlike structures where intense star formation occurs, forming a very different environment compared to galactic disks. We pair ∼0.″3 (30 pc) resolution new JWST/MIRI imaging with archival ALMA CO(2-1) mapping of the central ∼5 kpc of the nearby barred spiral galaxy NGC 1365 to investigate the
While the direct toxicological effects of metal exposure on animals, including birds, are well documented, indirect mechanisms remain poorly understood. This applies to effects on microbiota, despite the emerging evidence of its crucial role in host's physiological functions. We investigated the metal exposure, growth, and fledging of great tits (Parus major) in six rural vs. industrial/urban area
Polyphagous insects rely on multiple cues to choose oviposition sites, including substrate temperature and nutritional quality, which often do not coincide. We examined how females of the invasive fly Drosophila suzukii make oviposition decisions when temperature and nutrition mismatch, and whether infection with the symbiotic bacterium Wolbachia influences these choices. We first quantified femal
In this study, Monte Carlo simulation of photon transport through sprays has been achieved using the online “Multi-Scattering” software. Such simulations were focused on evaluating the accuracy of light transmission measurement of four distinct methods using diffuse light illumination without filtering (1),collimated homogeneous laser beam without filtering (2), structured collimated laser beam wi
ALICE is a large experiment at the CERN Large Hadron Collider. Located 52 meters underground, its detectors are suitable to measure muons produced by cosmic-ray interactions in the atmosphere. In this paper, the studies of the cosmic muons registered by ALICE during Run 2 (2015–2018) are described. The analysis is limited to multimuon events defined as events with more than four detected muons (Nµ
Water balance models provide insights into ongoing changes in the water cycle. Among them, monthly water balance models (MWBMs) are especially suitable for large-sample and global assessments, which are important for adaptation to global environmental change. This study evaluates monthly water balances from 14 models across more than 2,000 global catchments, comparing the modelś capacities to repr
In recognition of outstanding articles published in the Journal of Comparative Physiology A, Editors’ and Readers’ Choice Awards are conferred annually to the top papers in the categories Original Research Paper and Review/Review-History Article. The recipients of the 2026 Editors’ Choice Awards were selected based on votes cast by the Editorial Board on articles published in 2025. In the category
Förvaltningsmyndigheter fyller en uppsjö av funktioner i det svenska sam hället och offentligt anställda fäller i utövandet av yrkesroll en stor mängd brett varierade beslut och uttalanden. Med tanke på vilken effekt dessa utta landen kan få för allmänheten kan man fråga sig vilka av en myndighets ställningstaganden som utgör ett överklagbart beslut. Frågan om förvalt ningsbesluts överklagbarhet
INTRODUCTION: People with longstanding hip and groin pain (LHGP) are often referred to orthopaedic care. Physical therapist-led interventions are recommended in consensus statements as the first line of treatment, but it is unknown if structured interventions are more effective than usual care. The aim of this trial is to evaluate the effectiveness of a structured physical therapist-led treatment
Introduction – Hand-arm vibration syndrome (HAVS) is a chronic disease to vessels and nerves caused by vibrations. In Sweden, the medical check-up for vibrations (MCV) implements the EU surveillance system to detect early cases. No earlier research has shown participation in MCVs, nor why MCVs is avoided. We aimed to improve the understanding on avoidance of MCVs among vibration-exposed workers. M
