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Objectives: To describe characteristics and primary healthcare utilisation in Danish patients with low back pain (LBP) or neck/thoracic spine pain (NTP) 8 years before and 2 years after assessment in secondary care. Methods: In this cohort study, we included patients aged ≥ 18 who were assessed at an outpatient spine clinic from 2013 to 2021 and linked self-reported information with national regis

Background: To determine whether obesity and markers of lipid metabolism are associated with radiological hand osteoarthritis (OA) in the Halland County Osteoarthritis (HALLOA) cohort. Methods: In this cross-sectional study, we included 231 participants aged 30–65 from the HALLOA cohort, which began in 2017 and is ongoing. Hand OA was defined as ≥ 2 joint groups (distal interphalangeal, proximal i

Background: Foot deformities, such as valgus and varus in the coronal plane and equinus in the sagittal plane, are common in children with cerebral palsy (CP). The purpose of this study was to describe the prevalence of coronal plane foot deformities and their association with the Gross Motor Function Classification System (GMFCS) level, age, CP subtype, and equinus in children with CP. Methods: A

Aggressive pituitary neuroendocrine tumors (PitNETs)/adenomas are characterized by progressive growth despite surgery and all standard medical therapies and radiotherapy. A subset will metastasize to the brain and/or distant locations and are termed metastatic PitNETs (pituitary carcinomas). Studies of potential prognostic markers have been limited due to the rarity of these tumors. A few recurren

Background and aim: The purpose of this study was to determine the effectiveness of antibacterial drugs through cluster analysis of antibiotic sensitivity data from clinical isolates of Acinetobacter and Pseudomonas spp., obtained from soft tissue wounds and burn injuries. Methods: The cohort included 76 clinical isolates of Acinetobacter and Pseudomonas spp. obtained from 141 patients (male – 95,

To meet climate targets, a global shift away from fossil fuels is essential. For sectors where electrification is impractical, it is crucial to find sustainable energy carriers. Renewable methanol is widely considered a promising fuel for powering heavy-duty applications like shipping, freight transport, agriculture, and industrial machines due to its various sustainable production methods. While

Glycerol-3-phosphate dehydrogenase is a biomedically important enzyme that plays a crucial role in lipid biosynthesis. It is activated by a ligand-gated conformational change that is necessary for the enzyme to reach a catalytically competent conformation capable of efficient transition-state stabilization. While the human form (hlGPDH) has been the subject of extensive structural and biochemical

In recent years, it has become increasingly clear that promiscuity plays a key role in the evolution of new enzyme function. This finding has helped to elucidate fundamental aspects of molecular evolution. While there has been extensive experimental work on enzyme promiscuity, computational modeling of the chemical details of such promiscuity has traditionally fallen behind the advances in experim

High quality research data and analytical code are essential for ensuring the credibility of scientific results, are key research outputs, and are crucial elements to facilitate reproducibility. However, in ecology and evolution (E&E) in particular, it is currently unknown how many journals have policies on data- and code-sharing for peer review purposes, or upon manuscript acceptance. Further

Background: Postinfectious autoimmune processes have been proposed as potential causal risk factors for obsessive-compulsive disorder (OCD). In this large population-based study, we aimed to clarify the familial coaggregation pattern between severe infections and OCD across clusters of relatives with varying degrees of relatedness. Methods: We identified 4,916,898 individuals born in Sweden betwee

Objectives This study aims to investigate (1) the microbial community composition by work characteristics and (2) the association between microbial genera level and inflammatory markers among recycling workers. Methods In this cross-sectional study, inhalable dust was collected with personal samplers from 49 production (86 samples) and 10 administrative workers (15 samples). Four groups of micro-o

Objectives: In axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients initiating secukinumab, we aimed to assess retention rates and proportions of patients achieving remission and low disease activity (LDA), according to disease activity measures and patient-reported outcomes at 24 and 48 months. Patients and methods: Data on patients with axSpA and PsA who initiated secukinumab t

Nowadays organisms encounter not only natural challenges from predators but also significant anthropogenic stressors, such as insecticides, which can profoundly disrupt their normal growth and behavior. However, the knowledge on their potential interactions remains largely unknown, particularly regarding how insecticides may affect predator-prey interactions and prey responses across multiple gene

Marine environments worldwide are increasingly threatened by warming, deoxygenation, and ocean acidification. These stressors can be recorded as alterations in foraminiferal geochemistry and morphology. We integrated morphological features with assemblage and geochemical records of benthic foraminifera from the Danish Straits at the entrance to the Baltic Sea, covering the Last Interglacial period

Globally, 3 billion people rely on solid biomass fuel for their everyday cooking, most often using inefficient cooking practices, leading to high exposure levels of household air pollution. This is subsequently associated with negative health and climate impact. Further, the inefficient use of biomass fuels applies pressure on natural forests, resulting in deforestation, loss of biodiversity, and

Rationale: Early detection, standardized therapy, adequate infrastructure, and strategies for quality improvement should constitute essential components of every hospital’s sepsis plan. Objectives: To investigate the extent to which recommendations from the sepsis guidelines are implemented and the availability of infrastructure for the care of patients with sepsis in acute-care hospitals. Methods

Colored sticky traps are used for management of many common agricultural insect pests. Several recent studies have shown that traps can be improved by systematically considering properties of color vision for the target species. In the current study, we extend this approach to spatial vision, using information about the interommatidial angle of an agriculturally important insect pest, western flow